Il nostro contributo

L’impatto scientifico misura l’influenza e la rilevanza delle scoperte e delle pubblicazioni di un istituto di ricerca. Per IFOM, l’impatto scientifico non si limita solo alla quantità di pubblicazioni, ma si estende alla qualità delle riviste su cui vengono pubblicati i nostri studi, alla visibilità dei nostri risultati e alla capacità di trasformare queste scoperte in avanzamenti concreti nella lotta contro il cancro.

Alberghini F, Petrocelli V, Rahmat M, Casola S

An epigenetic view of B-cell disorders.

Immunol Cell Biol 2015; 253-60. doi: 10.1038/icb.2014.116

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Disanza A, Scita G

Nuclear and cellular plasticity: nuclear RAC1 takes center stage.

Dev Cell 2015; 261-3. doi: 10.1016/j.devcel.2015.01.015

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Kumar R, Bach MP, Mainoldi F, Maruya M, Kishigami S, Jumaa H, Wakayama T, Kanagawa O, Fagarasan S, Casola S

Antibody repertoire diversification through VH gene replacement in mice cloned from an IgA plasma cell.

Proc Natl Acad Sci U S A 2015; E450-7. doi: 10.1073/pnas.1417988112

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Manfrini N, Trovesi C, Wery M, Martina M, Cesena D, Descrimes M, Morillon A, d'Adda di Fagagna F, Longhese MP

RNA-processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA.

EMBO Rep 2015; 221-31. doi: 10.15252/embr.201439458

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Malet-Engra G, Yu W, Oldani A, Rey-Barroso J, Gov NS, Scita G, Dupré L

Collective cell motility promotes chemotactic prowess and resistance to chemorepulsion.

Curr Biol 2015; 242-250. doi: 10.1016/j.cub.2014.11.030

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Gioia U, d'Adda di Fagagna F

Human nuclear ARGONAUTE 2 interacts in vivo only with small RNAs and not with DNA.

Cell Cycle 2015; 2001-2. doi: 10.1080/15384101.2015.1044171

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Corallino S, Malabarba MG, Zobel M, Di Fiore PP, Scita G

Epithelial-to-Mesenchymal Plasticity Harnesses Endocytic Circuitries.

Front Oncol 2015; 45. doi: 10.3389/fonc.2015.00045

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Cremaschi P, Oliverio M, Leva V, Bione S, Carriero R, Mazzucco G, Palamidessi A, Scita G, Biamonti G, Montecucco A

Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells.

PLoS One 2015; e0130561. doi: 10.1371/journal.pone.0130561

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Gay S, Foiani M

Nuclear envelope and chromatin, lock and key of genome integrity.

Int Rev Cell Mol Biol 2015; 267-330. doi: 10.1016/bs.ircmb.2015.03.001

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Hobor S, Van Emburgh BO, Crowley E, Misale S, Di Nicolantonio F, Bardelli A

TGFα and amphiregulin paracrine network promotes resistance to EGFR blockade in colorectal cancer cells.

Clin Cancer Res 2014; 6429-38. doi: 10.1158/1078-0432.CCR-14-0774

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Elgendy M, Ciro M, Abdel-Aziz AK, Belmonte G, Dal Zuffo R, Mercurio C, Miracco C, Lanfrancone L, Foiani M, Minucci S

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner.

Nat Commun 2014; 5637. doi: 10.1038/ncomms6637

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Matafora V, Zagato L, Ferrandi M, Molinari I, Zerbini G, Casamassima N, Lanzani C, Delli Carpini S, Trepiccione F, Manunta P, Bachi A, Capasso G

Quantitative proteomics reveals novel therapeutic and diagnostic markers in hypertension.

BBA Clin 2014; 79-87. doi: 10.1016/j.bbacli.2014.10.001

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Mari S, Ruetalo N, Maspero E, Stoffregen MC, Pasqualato S, Polo S, Wiesner S

Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases.

Structure 2014; 1639-49. doi: 10.1016/j.str.2014.09.006

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Misale S, Di Nicolantonio F, Sartore-Bianchi A, Siena S, Bardelli A

Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution.

Cancer Discov 2014; 1269-80. doi: 10.1158/2159-8290.CD-14-0462

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Crespo CL, Vernieri C, Keller PJ, Garrè M, Bender JR, Wittbrodt J, Pardi R

The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes.

J Cell Sci 2014; 4381-95. doi: 10.1242/jcs.146217

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Persaud A, Alberts P, Mari S, Tong J, Murchie R, Maspero E, Safi F, Moran MF, Polo S, Rotin D

Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity.

Sci Signal 2014; ra95. doi: 10.1126/scisignal.2005290

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Abe T, Branzei D

High levels of BRC4 induced by a Tet-On 3G system suppress DNA repair and impair cell proliferation in vertebrate cells.

DNA Repair (Amst) 2014; 153-64. doi: 10.1016/j.dnarep.2014.08.003

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Giannattasio M, Zwicky K, Follonier C, Foiani M, Lopes M, Branzei D

Visualization of recombination-mediated damage bypass by template switching.

Nat Struct Mol Biol 2014; 884-92. doi: 10.1038/nsmb.2888

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Van Emburgh BO, Sartore-Bianchi A, Di Nicolantonio F, Siena S, Bardelli A

Acquired resistance to EGFR-targeted therapies in colorectal cancer.

Mol Oncol 2014; 1084-94. doi: 10.1016/j.molonc.2014.05.003

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Lamba S, Russo M, Sun C, Lazzari L, Cancelliere C, Grernrum W, Lieftink C, Bernards R, Di Nicolantonio F, Bardelli A

RAF suppression synergizes with MEK inhibition in KRAS mutant cancer cells.

Cell Rep 2014; 1475-83. doi: 10.1016/j.celrep.2014.07.033

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Rolland Y, Marighetti P, Malinverno C, Confalonieri S, Luise C, Ducano N, Palamidessi A, Bisi S, Kajiho H, Troglio F, Shcherbakova OG, Dunn AR, Oldani A, Lanzetti L, Di Fiore PP, Disanza A, Scita G

The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination.

Dev Cell 2014; 553-68. doi: 10.1016/j.devcel.2014.08.006

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Kramarz K, Litwin I, Cal-Bąkowska M, Szakal B, Branzei D, Wysocki R, Dziadkowiec D

Swi2/Snf2-like protein Uls1 functions in the Sgs1-dependent pathway of maintenance of rDNA stability and alleviation of replication stress.

DNA Repair (Amst) 2014; 24-35. doi: 10.1016/j.dnarep.2014.05.008

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Simonetti G, Bertilaccio MT, Rodriguez TV, Apollonio B, Dagklis A, Rocchi M, Innocenzi A, Casola S, Winkler TH, Nitschke L, Ponzoni M, Caligaris-Cappio F, Ghia P

SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.

Haematologica 2014; 1356-64. doi: 10.3324/haematol.2013.100230

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Kumar A, Mazzanti M, Mistrik M, Kosar M, Beznoussenko GV, Mironov AA, Garrè M, Parazzoli D, Shivashankar GV, Scita G, Bartek J, Foiani M

ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress.

Cell 2014; 633-46. doi: 10.1016/j.cell.2014.05.046

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Frittoli E, Palamidessi A, Marighetti P, Confalonieri S, Bianchi F, Malinverno C, Mazzarol G, Viale G, Martin-Padura I, Garré M, Parazzoli D, Mattei V, Cortellino S, Bertalot G, Di Fiore PP, Scita G

A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination.

J Cell Biol 2014; 307-28. doi: 10.1083/jcb.201403127

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Gritenaite D, Princz LN, Szakal B, Bantele SC, Wendeler L, Schilbach S, Habermann BH, Matos J, Lisby M, Branzei D, Pfander B

A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication.

Genes Dev 2014; 1604-19. doi: 10.1101/gad.240515.114

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Cazzalini O, Sommatis S, Tillhon M, Dutto I, Bachi A, Rapp A, Nardo T, Scovassi AI, Necchi D, Cardoso MC, Stivala LA, Prosperi E

CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis.

Nucleic Acids Res 2014; 8433-48. doi: 10.1093/nar/gku533

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Boissan M, Montagnac G, Shen Q, Griparic L, Guitton J, Romao M, Sauvonnet N, Lagache T, Lascu I, Raposo G, Desbourdes C, Schlattner U, Lacombe ML, Polo S, van der Bliek AM, Roux A, Chavrier P

Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling.

Science 2014; 1510-5. doi: 10.1126/science.1253768

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Esposito A, Bardelli A, Criscitiello C, Colombo N, Gelao L, Fumagalli L, Minchella I, Locatelli M, Goldhirsch A, Curigliano G

Monitoring tumor-derived cell-free DNA in patients with solid tumors: clinical perspectives and research opportunities.

Cancer Treat Rev 2014; 648-55. doi: 10.1016/j.ctrv.2013.10.003

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Ogrunc M, Di Micco R, Liontos M, Bombardelli L, Mione M, Fumagalli M, Gorgoulis VG, d'Adda di Fagagna F

Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation.

Cell Death Differ 2014; 998-1012. doi: 10.1038/cdd.2014.16

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Rossiello F, Herbig U, Longhese MP, Fumagalli M, d'Adda di Fagagna F

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing.

Curr Opin Genet Dev 2014; 89-95. doi: 10.1016/j.gde.2014.06.009

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Siravegna G, Bardelli A

Minimal residual disease in breast cancer: in blood veritas.

Clin Cancer Res 2014; 2505-7. doi: 10.1158/1078-0432.CCR-14-0370

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Raule M, Cerruti F, Benaroudj N, Migotti R, Kikuchi J, Bachi A, Navon A, Dittmar G, Cascio P

PA28αβ reduces size and increases hydrophilicity of 20S immunoproteasome peptide products.

Chem Biol 2014; 470-480. doi: 10.1016/j.chembiol.2014.02.006

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Piunti A, Rossi A, Cerutti A, Albert M, Jammula S, Scelfo A, Cedrone L, Fragola G, Olsson L, Koseki H, Testa G, Casola S, Helin K, d'Adda di Fagagna F, Pasini D

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication.

Nat Commun 2014; 3649. doi: 10.1038/ncomms4649

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Sun C, Hobor S, Bertotti A, Zecchin D, Huang S, Galimi F, Cottino F, Prahallad A, Grernrum W, Tzani A, Schlicker A, Wessels LF, Smit EF, Thunnissen E, Halonen P, Lieftink C, Beijersbergen RL, Di Nicolantonio F, Bardelli A, Trusolino L, Bernards R

Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.

Cell Rep 2014; 86-93. doi: 10.1016/j.celrep.2014.02.045

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Sun C, Wang L, Huang S, Heynen GJ, Prahallad A, Robert C, Haanen J, Blank C, Wesseling J, Willems SM, Zecchin D, Hobor S, Bajpe PK, Lieftink C, Mateus C, Vagner S, Grernrum W, Hofland I, Schlicker A, Wessels LF, Beijersbergen RL, Bardelli A, Di Nicolantonio F, Eggermont AM, Bernards R

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma.

Nature 2014; 118-22. doi: 10.1038/nature13121

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d'Adda di Fagagna F

A direct role for small non-coding RNAs in DNA damage response.

Trends Cell Biol 2014; 171-8. doi: 10.1016/j.tcb.2013.09.008

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Gonzalez-Huici V, Szakal B, Urulangodi M, Psakhye I, Castellucci F, Menolfi D, Rajakumara E, Fumasoni M, Bermejo R, Jentsch S, Branzei D

DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity.

EMBO J 2014; 327-40. doi: 10.1002/embj.201387425

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Foiani M, Bartek J

Golgi feels DNA's pain.

Cell 2014; 392-3. doi: 10.1016/j.cell.2014.01.030

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Russo M, Di Nicolantonio F, Bardelli A

Climbing RAS, the everest of oncogenes.

Cancer Discov 2014; 19-21. doi: 10.1158/2159-8290.CD-13-0906

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Fumagalli M, Rossiello F, Mondello C, d'Adda di Fagagna F

Stable cellular senescence is associated with persistent DDR activation.

PLoS One 2014; e110969. doi: 10.1371/journal.pone.0110969

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Achar YJ, Foiani M

Dangerous liaisons: MYCN meets condensins.

Cell Cycle 2014; 1225-6. doi: 10.4161/cc.28569

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Polo S, Di Fiore PP, Sigismund S

Keeping EGFR signaling in check: ubiquitin is the guardian.

Cell Cycle 2014; 681-2. doi: 10.4161/cc.27855

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Palazzo L, Della Monica R, Visconti R, Costanzo V, Grieco D

ATM controls proper mitotic spindle structure.

Cell Cycle 2014; 1091-100. doi: 10.4161/cc.27945

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Errico A, Aze A, Costanzo V

Mta2 promotes Tipin-dependent maintenance of replication fork integrity.

Cell Cycle 2014; 2120-8. doi: 10.4161/cc.29157

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D'Antonio M, Guerra RF, Cereda M, Marchesi S, Montani F, Nicassio F, Di Fiore PP, Ciccarelli FD

Recessive cancer genes engage in negative genetic interactions with their functional paralogs.

Cell Rep 2013; 1519-26. doi: 10.1016/j.celrep.2013.11.033

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Palamidessi A, Frittoli E, Ducano N, Offenhauser N, Sigismund S, Kajiho H, Parazzoli D, Oldani A, Gobbi M, Serini G, Di Fiore PP, Scita G, Lanzetti L

The GTPase-activating protein RN-tre controls focal adhesion turnover and cell migration.

Curr Biol 2013; 2355-64. doi: 10.1016/j.cub.2013.09.060

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Disanza A, Bisi S, Winterhoff M, Milanesi F, Ushakov DS, Kast D, Marighetti P, Romet-Lemonne G, Müller HM, Nickel W, Linkner J, Waterschoot D, Ampè C, Cortellino S, Palamidessi A, Dominguez R, Carlier MF, Faix J, Scita G

CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP.

EMBO J 2013; 2735-50. doi: 10.1038/emboj.2013.208

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Bisi S, Disanza A, Malinverno C, Frittoli E, Palamidessi A, Scita G

Membrane and actin dynamics interplay at lamellipodia leading edge.

Curr Opin Cell Biol 2013; 565-73. doi: 10.1016/j.ceb.2013.04.001

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Vernieri C, Chiroli E, Francia V, Gross F, Ciliberto A

Adaptation to the spindle checkpoint is regulated by the interplay between Cdc28/Clbs and PP2ACdc55.

J Cell Biol 2013; 765-78. doi: 10.1083/jcb.201303033

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