Il nostro contributo

L’impatto scientifico misura l’influenza e la rilevanza delle scoperte e delle pubblicazioni di un istituto di ricerca. Per IFOM, l’impatto scientifico non si limita solo alla quantità di pubblicazioni, ma si estende alla qualità delle riviste su cui vengono pubblicati i nostri studi, alla visibilità dei nostri risultati e alla capacità di trasformare queste scoperte in avanzamenti concreti nella lotta contro il cancro.

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Costanzo V, Bardelli A, Siena S, Abrignani S

Exploring the links between cancer and placenta development.

Open Biol 2018; . doi: 10.1098/rsob.180081

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Srinivasan M, Scheinost JC, Petela NJ, Gligoris TG, Wissler M, Ogushi S, Collier JE, Voulgaris M, Kurze A, Chan KL, Hu B, Costanzo V, Nasmyth KA

The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as well as Topological Mechanisms.

Cell 2018; 1508-1519.e18. doi: 10.1016/j.cell.2018.04.015

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Corallino S, Malinverno C, Neumann B, Tischer C, Palamidessi A, Frittoli E, Panagiotakopoulou M, Disanza A, Malet-Engra G, Nastaly P, Galli C, Luise C, Bertalot G, Pece S, Di Fiore PP, Gauthier N, Ferrari A, Maiuri P, Scita G

Author Correction: A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.

Nat Commun 2018; 2085. doi: 10.1038/s41467-018-04515-y

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Balestrieri C, Alfarano G, Milan M, Tosi V, Prosperini E, Nicoli P, Palamidessi A, Scita G, Diaferia GR, Natoli G

Co-optation of Tandem DNA Repeats for the Maintenance of Mesenchymal Identity.

Cell 2018; 1150-1164.e14. doi: 10.1016/j.cell.2018.03.081

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Gay S, Piccini D, Bruhn C, Ricciardi S, Soffientini P, Carotenuto W, Biffo S, Foiani M

A Mad2-Mediated Translational Regulatory Mechanism Promoting S-Phase Cyclin Synthesis Controls Origin Firing and Survival to Replication Stress.

Mol Cell 2018; 628-638.e5. doi: 10.1016/j.molcel.2018.04.020

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Sathe M, Muthukrishnan G, Rae J, Disanza A, Thattai M, Scita G, Parton RG, Mayor S

Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis.

Nat Commun 2018; 1835. doi: 10.1038/s41467-018-03955-w

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Siena S, Sartore-Bianchi A, Marsoni S, Hurwitz HI, McCall SJ, Penault-Llorca F, Srock S, Bardelli A, Trusolino L

Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer.

Ann Oncol 2018; 1108-1119. doi: 10.1093/annonc/mdy100

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Coquel F, Silva MJ, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, Promonet A, Cribier A, Sarrazin A, Niedzwiedz W, Lopez B, Costanzo V, Krejci L, Chabes A, Benkirane M, Lin YL, Pasero P

SAMHD1 acts at stalled replication forks to prevent interferon induction.

Nature 2018; 57-61. doi: 10.1038/s41586-018-0050-1

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Michelini F, Jalihal AP, Francia S, Meers C, Neeb ZT, Rossiello F, Gioia U, Aguado J, Jones-Weinert C, Luke B, Biamonti G, Nowacki M, Storici F, Carninci P, Walter NG, d'Adda di Fagagna F

From "Cellular" RNA to "Smart" RNA: Multiple Roles of RNA in Genome Stability and Beyond.

Chem Rev 2018; 4365-4403. doi: 10.1021/acs.chemrev.7b00487

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A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.

Nat Commun 2018; 1475. doi: 10.1038/s41467-018-03571-8

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Montagut C, Argilés G, Ciardiello F, Poulsen TT, Dienstmann R, Kragh M, Kopetz S, Lindsted T, Ding C, Vidal J, Clausell-Tormos J, Siravegna G, Sánchez-Martín FJ, Koefoed K, Pedersen MW, Grandal MM, Dvorkin M, Wyrwicz L, Rovira A, Cubillo A, Salazar R, Desseigne F, Nadal C, Albanell J, Zagonel V, Siena S, Fumi G, Rospo G, Nadler P, Horak ID, Bardelli A, Tabernero J

Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial.

JAMA Oncol 2018; e175245. doi: 10.1001/jamaoncol.2017.5245

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Nguyen Q, Aguado J, Iannelli F, Suzuki AM, Rossiello F, d'Adda di Fagagna F, Carninci P

Target-enrichment sequencing for detailed characterization of small RNAs.

Nat Protoc 2018; 768-786. doi: 10.1038/nprot.2018.001

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Catucci I, Osorio A, Arver B, Neidhardt G, Bogliolo M, Zanardi F, Riboni M, Minardi S, Pujol R, Azzollini J, Peissel B, Manoukian S, De Vecchi G, Casola S, Hauke J, Richters L, Rhiem K, Schmutzler RK, Wallander K, Törngren T, Borg Å, Radice P, Surrallés J, Hahnen E, Ehrencrona H, Kvist A, Benitez J, Peterlongo P

Individuals with FANCM biallelic mutations do not develop Fanconi anemia, but show risk for breast cancer, chemotherapy toxicity and may display chromosome fragility.

Genet Med 2018; 452-457. doi: 10.1038/gim.2017.123

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Adamowicz M, d'Adda di Fagagna F, Vermezovic J

NOTCH1 modulates activity of DNA-PKcs.

Mutat Res 2018; 20-27. doi: 10.1016/j.mrfmmm.2018.01.003

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Gerboth S, Frittoli E, Palamidessi A, Baltanas FC, Salek M, Rappsilber J, Giuliani C, Troglio F, Rolland Y, Pruneri G, Kreutmair S, Pallavicini I, Zobel M, Cinquanta M, Minucci S, Gomez C, Santos E, Illert AL, Scita G

Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.

Leukemia 2018; 820-827. doi: 10.1038/leu.2017.267

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Vernieri C, Nichetti F, Raimondi A, Pusceddu S, Platania M, Berrino F, de Braud F

Diet and supplements in cancer prevention and treatment: Clinical evidences and future perspectives.

Crit Rev Oncol Hematol 2018; 57-73. doi: 10.1016/j.critrevonc.2018.01.002

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Polovnikov KE, Gherardi M, Cosentino-Lagomarsino M, Tamm MV

Fractal Folding and Medium Viscoelasticity Contribute Jointly to Chromosome Dynamics.

Phys Rev Lett 2018; 088101. doi: 10.1103/PhysRevLett.120.088101

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Brambati A, Zardoni L, Achar YJ, Piccini D, Galanti L, Colosio A, Foiani M, Liberi G

Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription.

Nucleic Acids Res 2018; 1227-1239. doi: 10.1093/nar/gkx945

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Gauthier NC, Roca-Cusachs P

Mechanosensing at integrin-mediated cell-matrix adhesions: from molecular to integrated mechanisms.

Curr Opin Cell Biol 2018; 20-26. doi: 10.1016/j.ceb.2017.12.014

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Bonaiuti P, Chiroli E, Gross F, Corno A, Vernieri C, Štefl M, Cosentino Lagomarsino M, Knop M, Ciliberto A

Cells Escape an Operational Mitotic Checkpoint through a Stochastic Process.

Curr Biol 2018; 28-37.e7. doi: 10.1016/j.cub.2017.11.031

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Luciani M, Di Febo T, Orsini M, Krasteva I, Cattaneo A, Podaliri Vulpiani M, Di Pancrazio C, Bachi A, Tittarelli M

Trypanosoma equiperdum Low Molecular Weight Proteins As Candidates for Specific Serological Diagnosis of Dourine.

Front Vet Sci 2018; 40. doi: 10.3389/fvets.2018.00040

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Grilli J, Cadart C, Micali G, Osella M, Cosentino Lagomarsino M

The Empirical Fluctuation Pattern of E. coli Division Control.

Front Microbiol 2018; 1541. doi: 10.3389/fmicb.2018.01541

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Yu S, Sheats J, Cicuta P, Sclavi B, Cosentino Lagomarsino M, Dorfman KD

Subdiffusion of loci and cytoplasmic particles are different in compressed Escherichia coli cells.

Commun Biol 2018; 176. doi: 10.1038/s42003-018-0185-5

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Piccini A, Castroflorio E, Valente P, Guarnieri FC, Aprile D, Michetti C, Bramini M, Giansante G, Pinto B, Savardi A, Cesca F, Bachi A, Cattaneo A, Wren JD, Fassio A, Valtorta F, Benfenati F, Giovedì S

APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development.

Cell Rep 2017; 3596-3611. doi: 10.1016/j.celrep.2017.11.073

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Bakunts A, Orsi A, Vitale M, Cattaneo A, Lari F, Tadè L, Sitia R, Raimondi A, Bachi A, van Anken E

Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude.

Elife 2017; . doi: 10.7554/eLife.27518

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Wang YH, Hariharan A, Bastianello G, Toyama Y, Shivashankar GV, Foiani M, Sheetz MP

DNA damage causes rapid accumulation of phosphoinositides for ATR signaling.

Nat Commun 2017; 2118. doi: 10.1038/s41467-017-01805-9

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Germano G, Lamba S, Rospo G, Barault L, Magrì A, Maione F, Russo M, Crisafulli G, Bartolini A, Lerda G, Siravegna G, Mussolin B, Frapolli R, Montone M, Morano F, de Braud F, Amirouchene-Angelozzi N, Marsoni S, D'Incalci M, Orlandi A, Giraudo E, Sartore-Bianchi A, Siena S, Pietrantonio F, Di Nicolantonio F, Bardelli A

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth.

Nature 2017; 116-120. doi: 10.1038/nature24673

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Michelini F, Pitchiaya S, Vitelli V, Sharma S, Gioia U, Pessina F, Cabrini M, Wang Y, Capozzo I, Iannelli F, Matti V, Francia S, Shivashankar GV, Walter NG, d'Adda di Fagagna F

Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks.

Nat Cell Biol 2017; 1400-1411. doi: 10.1038/ncb3643

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Teske C, Schweitzer C, Palamidessi A, Aust DE, Scita G, Weitz J, Welsch T

Modulation of RAB5A early endosome trafficking in response to KRas mediated macropinocytic fluxes in pancreatic cancer cells.

Biochem Biophys Res Commun 2017; 528-533. doi: 10.1016/j.bbrc.2017.08.157

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Kawasumi R, Abe T, Arakawa H, Garre M, Hirota K, Branzei D

ESCO1/2's roles in chromosome structure and interphase chromatin organization.

Genes Dev 2017; 2136-2150. doi: 10.1101/gad.306084.117

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Pontes B, Monzo P, Gauthier NC

Membrane tension: A challenging but universal physical parameter in cell biology.

Semin Cell Dev Biol 2017; 30-41. doi: 10.1016/j.semcdb.2017.08.030

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D'Alessandro G, d'Adda di Fagagna F

Transcription and DNA Damage: Holding Hands or Crossing Swords?

J Mol Biol 2017; 3215-3229. doi: 10.1016/j.jmb.2016.11.002

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Taglialatela A, Alvarez S, Leuzzi G, Sannino V, Ranjha L, Huang JW, Madubata C, Anand R, Levy B, Rabadan R, Cejka P, Costanzo V, Ciccia A

Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.

Mol Cell 2017; 414-430.e8. doi: 10.1016/j.molcel.2017.09.036

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Zadorozhny K, Sannino V, Beláň O, Mlčoušková J, Špírek M, Costanzo V, Krejčí L

Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection.

Cell Rep 2017; 333-340. doi: 10.1016/j.celrep.2017.09.062

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Gherardi M, Calabrese L, Tamm M, Cosentino Lagomarsino M

Model of chromosomal loci dynamics in bacteria as fractional diffusion with intermittent transport.

Phys Rev E 2017; 042402. doi: 10.1103/PhysRevE.96.042402

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Kolinjivadi AM, Sannino V, De Antoni A, Zadorozhny K, Kilkenny M, Técher H, Baldi G, Shen R, Ciccia A, Pellegrini L, Krejci L, Costanzo V

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.

Mol Cell 2017; 867-881.e7. doi: 10.1016/j.molcel.2017.07.001

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Pontes B, Monzo P, Gole L, Le Roux AL, Kosmalska AJ, Tam ZY, Luo W, Kan S, Viasnoff V, Roca-Cusachs P, Tucker-Kellogg L, Gauthier NC

Membrane tension controls adhesion positioning at the leading edge of cells.

J Cell Biol 2017; 2959-2977. doi: 10.1083/jcb.201611117

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Tod J, Hanley CJ, Morgan MR, Rucka M, Mellows T, Lopez MA, Kiely P, Moutasim KA, Frampton SJ, Sabnis D, Fine DR, Johnson C, Marshall JF, Scita G, Jenei V, Thomas GJ

Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch.

J Pathol 2017; 37-50. doi: 10.1002/path.4923

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Siravegna G, Marsoni S, Siena S, Bardelli A

Integrating liquid biopsies into the management of cancer.

Nat Rev Clin Oncol 2017; 531-548. doi: 10.1038/nrclinonc.2017.14

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Fajner V, Maspero E, Polo S

Targeting HECT-type E3 ligases - insights from catalysis, regulation and inhibitors.

FEBS Lett 2017; 2636-2647. doi: 10.1002/1873-3468.12775

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Vernieri C, Milano M, Mennitto A, Maggi C, Ferrari B, Rinaldi L, Mennitto R, Stefanetti C, Re B, Mariani G, Bianchi G, Capri G, de Braud F

Antitumor activity and safety profile of weekly carboplatin plus paclitaxel in metastatic breast cancer: a ten-year, monocentric, retrospective study.

Breast Cancer Res Treat 2017; 365-373. doi: 10.1007/s10549-017-4336-z

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Vitelli V, Galbiati A, Iannelli F, Pessina F, Sharma S, d'Adda di Fagagna F

Recent Advancements in DNA Damage-Transcription Crosstalk and High-Resolution Mapping of DNA Breaks.

Annu Rev Genomics Hum Genet 2017; 87-113. doi: 10.1146/annurev-genom-091416-035314

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Zhang Q, Bassetti F, Gherardi M, Lagomarsino MC

Cell-to-cell variability and robustness in S-phase duration from genome replication kinetics.

Nucleic Acids Res 2017; 8190-8198. doi: 10.1093/nar/gkx556

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Branzei D, Szakal B

Building up and breaking down: mechanisms controlling recombination during replication.

Crit Rev Biochem Mol Biol 2017; 381-394. doi: 10.1080/10409238.2017.1304355

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Rohban S, Cerutti A, Morelli MJ, d'Adda di Fagagna F, Campaner S

The cohesin complex prevents Myc-induced replication stress.

Cell Death Dis 2017; e2956. doi: 10.1038/cddis.2017.345

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De Lazzari E, Grilli J, Maslov S, Cosentino Lagomarsino M

Family-specific scaling laws in bacterial genomes.

Nucleic Acids Res 2017; 7615-7622. doi: 10.1093/nar/gkx510

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Oddo D, Siravegna G, Gloghini A, Vernieri C, Mussolin B, Morano F, Crisafulli G, Berenato R, Corti G, Volpi CC, Buscarino M, Niger M, Dunne PD, Rospo G, Valtorta E, Bartolini A, Fucà G, Lamba S, Martinetti A, Di Bartolomeo M, de Braud F, Bardelli A, Pietrantonio F, Di Nicolantonio F