Il nostro contributo

L’impatto scientifico misura l’influenza e la rilevanza delle scoperte e delle pubblicazioni di un istituto di ricerca. Per IFOM, l’impatto scientifico non si limita solo alla quantità di pubblicazioni, ma si estende alla qualità delle riviste su cui vengono pubblicati i nostri studi, alla visibilità dei nostri risultati e alla capacità di trasformare queste scoperte in avanzamenti concreti nella lotta contro il cancro.

Capozzo I, Iannelli F, Francia S, d'Adda di Fagagna F

Express or repress? The transcriptional dilemma of damaged chromatin.

FEBS J 2017; 2133-2147. doi: 10.1111/febs.14048

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Forcato M, Nicoletti C, Pal K, Livi CM, Ferrari F, Bicciato S

Comparison of computational methods for Hi-C data analysis.

Nat Methods 2017; 679-685. doi: 10.1038/nmeth.4325

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Varano G, Raffel S, Sormani M, Zanardi F, Lonardi S, Zasada C, Perucho L, Petrocelli V, Haake A, Lee AK, Bugatti M, Paul U, Van Anken E, Pasqualucci L, Rabadan R, Siebert R, Kempa S, Ponzoni M, Facchetti F, Rajewsky K, Casola S

The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.

Nature 2017; 302-306. doi: 10.1038/nature22353

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Siravegna G, Sartore-Bianchi A, Mussolin B, Cassingena A, Amatu A, Novara L, Buscarino M, Corti G, Crisafulli G, Bartolini A, Tosi F, Erlander M, Di Nicolantonio F, Siena S, Bardelli A

Tracking a CAD-ALK gene rearrangement in urine and blood of a colorectal cancer patient treated with an ALK inhibitor.

Ann Oncol 2017; 1302-1308. doi: 10.1093/annonc/mdx095

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Sheats J, Sclavi B, Cosentino Lagomarsino M, Cicuta P, Dorfman KD

Role of growth rate on the orientational alignment of Escherichia coli in a slit.

R Soc Open Sci 2017; 170463. doi: 10.1098/rsos.170463

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Puddu F, Salguero I, Herzog M, Geisler NJ, Costanzo V, Jackson SP

Chromatin determinants impart camptothecin sensitivity.

EMBO Rep 2017; 1000-1012. doi: 10.15252/embr.201643560

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Iannelli F, Galbiati A, Capozzo I, Nguyen Q, Magnuson B, Michelini F, D'Alessandro G, Cabrini M, Roncador M, Francia S, Crosetto N, Ljungman M, Carninci P, d'Adda di Fagagna F

A damaged genome's transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks.

Nat Commun 2017; 15656. doi: 10.1038/ncomms15656

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Caldieri G, Barbieri E, Nappo G, Raimondi A, Bonora M, Conte A, Verhoef LGGC, Confalonieri S, Malabarba MG, Bianchi F, Cuomo A, Bonaldi T, Martini E, Mazza D, Pinton P, Tacchetti C, Polo S, Di Fiore PP, Sigismund S

Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis.

Science 2017; 617-624. doi: 10.1126/science.aah6152

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Malinverno C, Corallino S, Giavazzi F, Bergert M, Li Q, Leoni M, Disanza A, Frittoli E, Oldani A, Martini E, Lendenmann T, Deflorian G, Beznoussenko GV, Poulikakos D, Haur OK, Uroz M, Trepat X, Parazzoli D, Maiuri P, Yu W, Ferrari A, Cerbino R, Scita G

Endocytic reawakening of motility in jammed epithelia.

Nat Mater 2017; 587-596. doi: 10.1038/nmat4848

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Matafora V, Corno A, Ciliberto A, Bachi A

Missing Value Monitoring Enhances the Robustness in Proteomics Quantitation.

J Proteome Res 2017; 1719-1727. doi: 10.1021/acs.jproteome.6b01056

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Petrakis TG, Komseli ES, Papaioannou M, Vougas K, Polyzos A, Myrianthopoulos V, Mikros E, Trougakos IP, Thanos D, Branzei D, Townsend P, Gorgoulis VG

Erratum to 'Exploring and exploiting the systemic effects of deregulated replication licensing' [Seminars in Cancer Biology 37-38C, (2016) 3-15].

Semin Cancer Biol 2017; 180. doi: 10.1016/j.semcancer.2017.02.002

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Galbiati A, Beauséjour C, d'Adda di Fagagna F

A novel single-cell method provides direct evidence of persistent DNA damage in senescent cells and aged mammalian tissues.

Aging Cell 2017; 422-427. doi: 10.1111/acel.12573

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Osella M, Tans SJ, Cosentino Lagomarsino M

Step by Step, Cell by Cell: Quantification of the Bacterial Cell Cycle.

Trends Microbiol 2017; 250-256. doi: 10.1016/j.tim.2016.12.005

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Kolinjivadi AM, Sannino V, de Antoni A, Técher H, Baldi G, Costanzo V

Moonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51.

FEBS Lett 2017; 1083-1100. doi: 10.1002/1873-3468.12556

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Muñoz MJ, Nieto Moreno N, Giono LE, Cambindo Botto AE, Dujardin G, Bastianello G, Lavore S, Torres-Méndez A, Menck CFM, Blencowe BJ, Irimia M, Foiani M, Kornblihtt AR

Major Roles for Pyrimidine Dimers, Nucleotide Excision Repair, and ATR in the Alternative Splicing Response to UV Irradiation.

Cell Rep 2017; 2868-2879. doi: 10.1016/j.celrep.2017.02.066

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Branzei D, Ciliberto A

Not all roads lead to Cdk1.

Cell Cycle 2017; 395-396. doi: 10.1080/15384101.2016.1274585

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Goyal L, Saha SK, Liu LY, Siravegna G, Leshchiner I, Ahronian LG, Lennerz JK, Vu P, Deshpande V, Kambadakone A, Mussolin B, Reyes S, Henderson L, Sun JE, Van Seventer EE, Gurski JM, Baltschukat S, Schacher-Engstler B, Barys L, Stamm C, Furet P, Ryan DP, Stone JR, Iafrate AJ, Getz G, Porta DG, Tiedt R, Bardelli A, Juric D, Corcoran RB, Bardeesy N, Zhu AX

Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma.

Cancer Discov 2017; 252-263. doi: 10.1158/2159-8290.CD-16-1000

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Heise C, Taha E, Murru L, Ponzoni L, Cattaneo A, Guarnieri FC, Montani C, Mossa A, Vezzoli E, Ippolito G, Zapata J, Barrera I, Ryazanov AG, Cook J, Poe M, Stephen MR, Kopanitsa M, Benfante R, Rusconi F, Braida D, Francolini M, Proud CG, Valtorta F, Passafaro M, Sala M, Bachi A, Verpelli C, Rosenblum K, Sala C

eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures.

Cereb Cortex 2017; 2226-2248. doi: 10.1093/cercor/bhw075

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Grilli J, Osella M, Kennard AS, Lagomarsino MC

Relevant parameters in models of cell division control.

Phys Rev E 2017; 032411. doi: 10.1103/PhysRevE.95.032411

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Rossiello F, Aguado J, Sepe S, Iannelli F, Nguyen Q, Pitchiaya S, Carninci P, d'Adda di Fagagna F

DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs.

Nat Commun 2017; 13980. doi: 10.1038/ncomms13980

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Co AD, Lagomarsino MC, Caselle M, Osella M

Stochastic timing in gene expression for simple regulatory strategies.

Nucleic Acids Res 2017; 1069-1078. doi: 10.1093/nar/gkw1235

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Ciliberto A, Hauf S

Micromanaging checkpoint proteins.

Elife 2017; . doi: 10.7554/eLife.25001

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Myant KB, Cammareri P, Hodder MC, Wills J, Von Kriegsheim A, Győrffy B, Rashid M, Polo S, Maspero E, Vaughan L, Gurung B, Barry E, Malliri A, Camargo F, Adams DJ, Iavarone A, Lasorella A, Sansom OJ

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.

EMBO Mol Med 2017; 181-197. doi: 10.15252/emmm.201606684

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Wanke F, Moos S, Croxford AL, Heinen AP, Gräf S, Kalt B, Tischner D, Zhang J, Christen I, Bruttger J, Yogev N, Tang Y, Zayoud M, Israel N, Karram K, Reißig S, Lacher SM, Reichhold C, Mufazalov IA, Ben-Nun A, Kuhlmann T, Wettschureck N, Sailer AW, Rajewsky K, Casola S, Waisman A, Kurschus FC

EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells.

Cell Rep 2017; 1270-1284. doi: 10.1016/j.celrep.2017.01.020

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Sebesta M, Urulangodi M, Stefanovie B, Szakal B, Pacesa M, Lisby M, Branzei D, Krejci L

Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains.

Nucleic Acids Res 2017; 215-230. doi: 10.1093/nar/gkw882

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Hoppe T, Branzei D

Stefan Jentsch (1955-2016)-Maestro of the ubiquitin family.

EMBO J 2017; 1-2. doi: 10.15252/embj.201696176

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Ruprecht V, Monzo P, Ravasio A, Yue Z, Makhija E, Strale PO, Gauthier N, Shivashankar GV, Studer V, Albiges-Rizo C, Viasnoff V

How cells respond to environmental cues - insights from bio-functionalized substrates.

J Cell Sci 2017; 51-61. doi: 10.1242/jcs.196162

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Raspelli E, Falbo L, Costanzo V

Xenopus egg extract to study regulation of genome-wide and locus-specific DNA replication.

Genesis 2017; . doi: 10.1002/dvg.22996

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Soffientini P, Bachi A

STAGE-Diging in Proteomics.

Methods Mol Biol 2017; 255-260. doi: 10.1007/978-1-4939-7231-9_18

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Gherardi M, Cosentino Lagomarsino M

Procedures for Model-Guided Data Analysis of Chromosomal Loci Dynamics at Short Time Scales.

Methods Mol Biol 2017; 291-307. doi: 10.1007/978-1-4939-7098-8_21

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Achar YJ, Foiani M

Coordinating Replication with Transcription.

Adv Exp Med Biol 2017; 455-487. doi: 10.1007/978-981-10-6955-0_20

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Petrocelli V, Casola S

Targeting Gene Function in Germinal Center B Cells: A Practical Approach.

Methods Mol Biol 2017; 209-231. doi: 10.1007/978-1-4939-7095-7_17

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Sannino V, Pezzimenti F, Bertora S, Costanzo V

Xenopus laevis as Model System to Study DNA Damage Response and Replication Fork Stability.

Methods Enzymol 2017; 211-232. doi: 10.1016/bs.mie.2017.03.018

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Bloom K, Costanzo V

Centromere Structure and Function.

Prog Mol Subcell Biol 2017; 515-539. doi: 10.1007/978-3-319-58592-5_21

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Van Emburgh BO, Arena S, Siravegna G, Lazzari L, Crisafulli G, Corti G, Mussolin B, Baldi F, Buscarino M, Bartolini A, Valtorta E, Vidal J, Bellosillo B, Germano G, Pietrantonio F, Ponzetti A, Albanell J, Siena S, Sartore-Bianchi A, Di Nicolantonio F, Montagut C, Bardelli A

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer.

Nat Commun 2016; 13665. doi: 10.1038/ncomms13665

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Vernieri C, Casola S, Foiani M, Pietrantonio F, de Braud F, Longo V

Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions.

Cancer Discov 2016; 1315-1333. doi: 10.1158/2159-8290.CD-16-0615

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Sannino V, Costanzo V

ATR checkpoint suppression by repetitive DNA.

Cell Cycle 2016; 2993-2994. doi: 10.1080/15384101.2016.1204870

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Romeo F, Falbo L, Costanzo V

Replication, checkpoint suppression and structure of centromeric DNA.

Nucleus 2016; 540-546. doi: 10.1080/19491034.2016.1255836

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Abe T, Kawasumi R, Arakawa H, Hori T, Shirahige K, Losada A, Fukagawa T, Branzei D

Chromatin determinants of the inner-centromere rely on replication factors with functions that impart cohesion.

Oncotarget 2016; 67934-67947. doi: 10.18632/oncotarget.11982

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Biondini M, Sadou-Dubourgnoux A, Paul-Gilloteaux P, Zago G, Arslanhan MD, Waharte F, Formstecher E, Hertzog M, Yu J, Guerois R, Gautreau A, Scita G, Camonis J, Parrini MC

Direct interaction between exocyst and Wave complexes promotes cell protrusions and motility.

J Cell Sci 2016; 3756-3769. doi: 10.1242/jcs.187336

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Wu KZ, Wang GN, Fitzgerald J, Quachthithu H, Rainey MD, Cattaneo A, Bachi A, Santocanale C

DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach.

Nucleic Acids Res 2016; 8786-8798. doi: 10.1093/nar/gkw626

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Soncini M, Corna G, Moresco M, Coltella N, Restuccia U, Maggioni D, Raccosta L, Lin CY, Invernizzi F, Crocchiolo R, Doglioni C, Traversari C, Bachi A, Bernardi R, Bordignon C, Gustafsson JÅ, Russo V

24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development.

Proc Natl Acad Sci U S A 2016; E6219-E6227. doi: 10.1073/pnas.1613332113

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Pietrantonio F, Oddo D, Gloghini A, Valtorta E, Berenato R, Barault L, Caporale M, Busico A, Morano F, Gualeni AV, Alessi A, Siravegna G, Perrone F, Di Bartolomeo M, Bardelli A, de Braud F, Di Nicolantonio F

MET-Driven Resistance to Dual EGFR and BRAF Blockade May Be Overcome by Switching from EGFR to MET Inhibition in BRAF-Mutated Colorectal Cancer.

Cancer Discov 2016; 963-71. doi: 10.1158/2159-8290.CD-16-0297

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Ballabeni A, Hemenway D, Scita G

Time to tackle the incumbency advantage in science: A survey of scientists shows strong support for funding policies that would distribute funds more evenly among laboratories and thereby benefit new and smaller research groups.

EMBO Rep 2016; 1254-6. doi: 10.15252/embr.201642998

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Adamowicz M, Vermezovic J, d'Adda di Fagagna F

NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex.

Cell Rep 2016; 2068-2076. doi: 10.1016/j.celrep.2016.07.038

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Oddo D, Sennott EM, Barault L, Valtorta E, Arena S, Cassingena A, Filiciotto G, Marzolla G, Elez E, van Geel RM, Bartolini A, Crisafulli G, Boscaro V, Godfrey JT, Buscarino M, Cancelliere C, Linnebacher M, Corti G, Truini M, Siravegna G, Grasselli J, Gallicchio M, Bernards R, Schellens JH, Tabernero J, Engelman JA, Sartore-Bianchi A, Bardelli A, Siena S, Corcoran RB, Di Nicolantonio F

Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer.

Cancer Res 2016; 4504-15. doi: 10.1158/0008-5472.CAN-16-0396

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Branzei D, Szakal B

DNA damage tolerance by recombination: Molecular pathways and DNA structures.

DNA Repair (Amst) 2016; 68-75. doi: 10.1016/j.dnarep.2016.05.008

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Reber S, Stettler J, Filosa G, Colombo M, Jutzi D, Lenzken SC, Schweingruber C, Bruggmann R, Bachi A, Barabino SM, Mühlemann O, Ruepp MD

Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.

EMBO J 2016; 1504-21. doi: 10.15252/embj.201593791

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Bonner JN, Choi K, Xue X, Torres NP, Szakal B, Wei L, Wan B, Arter M, Matos J, Sung P, Brown GW, Branzei D, Zhao X

Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates.

Cell Rep 2016; 368-378. doi: 10.1016/j.celrep.2016.06.015

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Cereda M, Gambardella G, Benedetti L, Iannelli F, Patel D, Basso G, Guerra RF, Mourikis TP, Puccio I, Sinha S, Laghi L, Spencer J, Rodriguez-Justo M, Ciccarelli FD

Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes.

Nat Commun 2016; 12072. doi: 10.1038/ncomms12072

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