Il nostro contributo

L’impatto scientifico misura l’influenza e la rilevanza delle scoperte e delle pubblicazioni di un istituto di ricerca. Per IFOM, l’impatto scientifico non si limita solo alla quantità di pubblicazioni, ma si estende alla qualità delle riviste su cui vengono pubblicati i nostri studi, alla visibilità dei nostri risultati e alla capacità di trasformare queste scoperte in avanzamenti concreti nella lotta contro il cancro.

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Kajiho H, Kajiho Y, Frittoli E, Confalonieri S, Bertalot G, Viale G, Di Fiore PP, Oldani A, Garre M, Beznoussenko GV, Palamidessi A, Vecchi M, Chavrier P, Perez F, Scita G

RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs.

EMBO Rep 2016; 1061-80. doi: 10.15252/embr.201642032

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Pozzi C, Cuomo A, Spadoni I, Magni E, Silvola A, Conte A, Sigismund S, Ravenda PS, Bonaldi T, Zampino MG, Cancelliere C, Di Fiore PP, Bardelli A, Penna G, Rescigno M

The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death.

Nat Med 2016; 624-31. doi: 10.1038/nm.4078

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Petrakis TG, Komseli ES, Papaioannou M, Vougas K, Polyzos A, Myrianthopoulos V, Mikros E, Trougakos IP, Thanos D, Branzei D, Townsend P, Gorgoulis VG

Exploring and exploiting the systemic effects of deregulated replication licensing.

Semin Cancer Biol 2016; 3-15. doi: 10.1016/j.semcancer.2015.12.002

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Branzei D, Psakhye I

DNA damage tolerance.

Curr Opin Cell Biol 2016; 137-144. doi: 10.1016/j.ceb.2016.03.015

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Aze A, Sannino V, Soffientini P, Bachi A, Costanzo V

Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression.

Nat Cell Biol 2016; 684-91. doi: 10.1038/ncb3344

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Soffientini P, Bachi A

STAGE-diging: A novel in-gel digestion processing for proteomics samples.

J Proteomics 2016; 48-54. doi: 10.1016/j.jprot.2016.03.038

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Pusceddu S, Buzzoni R, Vernieri C, Concas L, Marceglia S, Giacomelli L, Milione M, Leuzzi L, Femia D, Formisano B, Mazzaferro V, de Braud F

Metformin with everolimus and octreotide in pancreatic neuroendocrine tumor patients with diabetes.

Future Oncol 2016; 1251-60. doi: 10.2217/fon-2015-0077

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McGarry E, Gaboriau D, Rainey MD, Restuccia U, Bachi A, Santocanale C

The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase.

Cancer Res 2016; 2384-93. doi: 10.1158/0008-5472.CAN-15-2890

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Vecchione L, Gambino V, Raaijmakers J, Schlicker A, Fumagalli A, Russo M, Villanueva A, Beerling E, Bartolini A, Mollevi DG, El-Murr N, Chiron M, Calvet L, Nicolazzi C, Combeau C, Henry C, Simon IM, Tian S, in 't Veld S, D'ario G, Mainardi S, Beijersbergen RL, Lieftink C, Linn S, Rumpf-Kienzl C, Delorenzi M, Wessels L, Salazar R, Di Nicolantonio F, Bardelli A, van Rheenen J, Medema RH, Tejpar S, Bernards R

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility.

Cell 2016; 317-30. doi: 10.1016/j.cell.2016.02.059

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Francia S, Cabrini M, Matti V, Oldani A, d'Adda di Fagagna F

DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors.

J Cell Sci 2016; 1468-76. doi: 10.1242/jcs.182188

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Wollscheid HP, Biancospino M, He F, Magistrati E, Molteni E, Lupia M, Soffientini P, Rottner K, Cavallaro U, Pozzoli U, Mapelli M, Walters KJ, Polo S

Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.

Nat Struct Mol Biol 2016; 300-308. doi: 10.1038/nsmb.3187

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He F, Wollscheid HP, Nowicka U, Biancospino M, Valentini E, Ehlinger A, Acconcia F, Magistrati E, Polo S, Walters KJ

Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains.

Cell Rep 2016; 2683-94. doi: 10.1016/j.celrep.2016.01.079

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Siravegna G, Bardelli A

Blood circulating tumor DNA for non-invasive genotyping of colon cancer patients.

Mol Oncol 2016; 475-80. doi: 10.1016/j.molonc.2015.12.005

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Arena S, Siravegna G, Mussolin B, Kearns JD, Wolf BB, Misale S, Lazzari L, Bertotti A, Trusolino L, Adjei AA, Montagut C, Di Nicolantonio F, Nering R, Bardelli A

MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations.

Sci Transl Med 2016; 324ra14. doi: 10.1126/scitranslmed.aad5640

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Savio MG, Wollscheid N, Cavallaro E, Algisi V, Di Fiore PP, Sigismund S, Maspero E, Polo S

USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15.

Curr Biol 2016; 173-183. doi: 10.1016/j.cub.2015.11.050

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Russo M, Misale S, Wei G, Siravegna G, Crisafulli G, Lazzari L, Corti G, Rospo G, Novara L, Mussolin B, Bartolini A, Cam N, Patel R, Yan S, Shoemaker R, Wild R, Di Nicolantonio F, Bianchi AS, Li G, Siena S, Bardelli A

Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer.

Cancer Discov 2016; 36-44. doi: 10.1158/2159-8290.CD-15-0940

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Sartore-Bianchi A, Ardini E, Bosotti R, Amatu A, Valtorta E, Somaschini A, Raddrizzani L, Palmeri L, Banfi P, Bonazzina E, Misale S, Marrapese G, Leone A, Alzani R, Luo D, Hornby Z, Lim J, Veronese S, Vanzulli A, Bardelli A, Martignoni M, Davite C, Galvani A, Isacchi A, Siena S

Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer.

J Natl Cancer Inst 2016; . doi: 10.1093/jnci/djv306

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Branzei D

DNA damage tolerance branches out toward sister chromatid cohesion.

Mol Cell Oncol 2016; e1035478. doi: 10.1080/23723556.2015.1035478

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Costa-Cabral S, Brough R, Konde A, Aarts M, Campbell J, Marinari E, Riffell J, Bardelli A, Torrance C, Lord CJ, Ashworth A

CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours.

PLoS One 2016; e0149099. doi: 10.1371/journal.pone.0149099

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Schweingruber C, Soffientini P, Ruepp MD, Bachi A, Mühlemann O

Identification of Interactions in the NMD Complex Using Proximity-Dependent Biotinylation (BioID).

PLoS One 2016; e0150239. doi: 10.1371/journal.pone.0150239

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Urulangodi M, Szakal B, Branzei D

SUMO-mediated global and local control of recombination.

Cell Cycle 2016; 160-1. doi: 10.1080/15384101.2015.1118918

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Branzei D, Menolfi D

G2/M chromosome transactions essentially relying on Smc5/6.

Cell Cycle 2016; 611-2. doi: 10.1080/15384101.2015.1131525

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Branzei D, Szakal B

Priming for tolerance and cohesion at replication forks.

Nucleus 2016; 8-12. doi: 10.1080/19491034.2016.1149663

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Sorrentino C, Boggio A, Confalonieri S, Hemenway D, Scita G, Ballabeni A

Increasing both the public health potential of basic research and the scientist satisfaction. An international survey of bio-scientists.

F1000Res 2016; 56. doi: 10.12688/f1000research.7683.2

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Sigismund S, Polo S

Strategies to Detect Endogenous Ubiquitination of a Target Mammalian Protein.

Methods Mol Biol 2016; 143-51. doi: 10.1007/978-1-4939-3756-1_6

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Maspero E, Polo S

In Vitro Ubiquitination: Self-Ubiquitination, Chain Formation, and Substrate Ubiquitination Assays.

Methods Mol Biol 2016; 153-60. doi: 10.1007/978-1-4939-3756-1_7

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Sannino V, Kolinjivadi AM, Baldi G, Costanzo V

Studying essential DNA metabolism proteins in Xenopus egg extract.

Int J Dev Biol 2016; 221-227. doi: 10.1387/ijdb.160103vc

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Vernieri C, Femia D, Pusceddu S, Capella C, Rosai J, Calareso G, Concas L, Prinzi N, Lo Russo G, de Braud F, Buzzoni R

Primary Cerebellar Neuroendocrine Tumors: Chimeras or Real Entities? A Case Report with a 6-Year Follow-Up.

Case Rep Oncol 2016; 432-439. doi: 10.1159/000447771

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Menolfi D, Delamarre A, Lengronne A, Pasero P, Branzei D

Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance.

Mol Cell 2015; 835-46. doi: 10.1016/j.molcel.2015.10.023

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Awasthi P, Foiani M, Kumar A

ATM and ATR signaling at a glance.

J Cell Sci 2015; 4255-62. doi: 10.1242/jcs.169730

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Mihailovich M, Bremang M, Spadotto V, Musiani D, Vitale E, Varano G, Zambelli F, Mancuso FM, Cairns DA, Pavesi G, Casola S, Bonaldi T

miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth.

Nat Commun 2015; 8725. doi: 10.1038/ncomms9725

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Hang LE, Peng J, Tan W, Szakal B, Menolfi D, Sheng Z, Lobachev K, Branzei D, Feng W, Zhao X

Rtt107 Is a Multi-functional Scaffold Supporting Replication Progression with Partner SUMO and Ubiquitin Ligases.

Mol Cell 2015; 268-79. doi: 10.1016/j.molcel.2015.08.023

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Rossi SE, Ajazi A, Carotenuto W, Foiani M, Giannattasio M

Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress.

Cell Rep 2015; 80-92. doi: 10.1016/j.celrep.2015.08.073

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Urulangodi M, Sebesta M, Menolfi D, Szakal B, Sollier J, Sisakova A, Krejci L, Branzei D

Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication.

Genes Dev 2015; 2067-80. doi: 10.1101/gad.265629.115

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Prahallad A, Heynen GJ, Germano G, Willems SM, Evers B, Vecchione L, Gambino V, Lieftink C, Beijersbergen RL, Di Nicolantonio F, Bardelli A, Bernards R

PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs.

Cell Rep 2015; 1978-85. doi: 10.1016/j.celrep.2015.08.037

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Misale S, Bozic I, Tong J, Peraza-Penton A, Lallo A, Baldi F, Lin KH, Truini M, Trusolino L, Bertotti A, Di Nicolantonio F, Nowak MA, Zhang L, Wood KC, Bardelli A

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.

Nat Commun 2015; 8305. doi: 10.1038/ncomms9305

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Barault L, Amatu A, Bleeker FE, Moutinho C, Falcomatà C, Fiano V, Cassingena A, Siravegna G, Milione M, Cassoni P, De Braud F, Rudà R, Soffietti R, Venesio T, Bardelli A, Wesseling P, de Witt Hamer P, Pietrantonio F, Siena S, Esteller M, Sartore-Bianchi A, Di Nicolantonio F

Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer.

Ann Oncol 2015; 1994-1999. doi: 10.1093/annonc/mdv272

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Capuani F, Conte A, Argenzio E, Marchetti L, Priami C, Polo S, Di Fiore PP, Sigismund S, Ciliberto A

Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells.

Nat Commun 2015; 7999. doi: 10.1038/ncomms8999

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Montagut C, Siravegna G, Bardelli A

Liquid biopsies to evaluate early therapeutic response in colorectal cancer.

Ann Oncol 2015; 1525-7. doi: 10.1093/annonc/mdv228

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Manfrini N, Clerici M, Wery M, Colombo CV, Descrimes M, Morillon A, d'Adda di Fagagna F, Longhese MP

Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae.

Elife 2015; . doi: 10.7554/eLife.08942

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Siravegna G, Mussolin B, Buscarino M, Corti G, Cassingena A, Crisafulli G, Ponzetti A, Cremolini C, Amatu A, Lauricella C, Lamba S, Hobor S, Avallone A, Valtorta E, Rospo G, Medico E, Motta V, Antoniotti C, Tatangelo F, Bellosillo B, Veronese S, Budillon A, Montagut C, Racca P, Marsoni S, Falcone A, Corcoran RB, Di Nicolantonio F, Loupakis F, Siena S, Sartore-Bianchi A, Bardelli A

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.

Nat Med 2015; 795-801. doi: 10.1038/nm.3870

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Xue X, Choi K, Bonner JN, Szakal B, Chen YH, Papusha A, Saro D, Niu H, Ira G, Branzei D, Sung P, Zhao X

Selective modulation of the functions of a conserved DNA motor by a histone fold complex.

Genes Dev 2015; 1000-5. doi: 10.1101/gad.259143.115

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Meena JK, Cerutti A, Beichler C, Morita Y, Bruhn C, Kumar M, Kraus JM, Speicher MR, Wang ZQ, Kestler HA, d'Adda di Fagagna F, Günes C, Rudolph KL

Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion.

EMBO J 2015; 1371-84. doi: 10.15252/embj.201490070

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Conti A, Majorini MT, Elliott R, Ashworth A, Lord CJ, Cancelliere C, Bardelli A, Seneci P, Walczak H, Delia D, Lecis D

Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway.

Oncotarget 2015; 10994-1008. doi: 10.18632/oncotarget.3552

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Arena S, Bellosillo B, Siravegna G, Martínez A, Cañadas I, Lazzari L, Ferruz N, Russo M, Misale S, González I, Iglesias M, Gavilan E, Corti G, Hobor S, Crisafulli G, Salido M, Sánchez J, Dalmases A, Bellmunt J, De Fabritiis G, Rovira A, Di Nicolantonio F, Albanell J, Bardelli A, Montagut C

Emergence of Multiple EGFR Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer.

Clin Cancer Res 2015; 2157-66. doi: 10.1158/1078-0432.CCR-14-2821

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Medico E, Russo M, Picco G, Cancelliere C, Valtorta E, Corti G, Buscarino M, Isella C, Lamba S, Martinoglio B, Veronese S, Siena S, Sartore-Bianchi A, Beccuti M, Mottolese M, Linnebacher M, Cordero F, Di Nicolantonio F, Bardelli A