Il nostro contributo

L’impatto scientifico misura l’influenza e la rilevanza delle scoperte e delle pubblicazioni di un istituto di ricerca. Per IFOM, l’impatto scientifico non si limita solo alla quantità di pubblicazioni, ma si estende alla qualità delle riviste su cui vengono pubblicati i nostri studi, alla visibilità dei nostri risultati e alla capacità di trasformare queste scoperte in avanzamenti concreti nella lotta contro il cancro.

Filtri

Anno

Autore

Publication type

Journal

Alberghini F, Petrocelli V, Rahmat M, Casola S

An epigenetic view of B-cell disorders.

Immunol Cell Biol 2015; 253-60. doi: 10.1038/icb.2014.116

Leggi ora

Disanza A, Scita G

Nuclear and cellular plasticity: nuclear RAC1 takes center stage.

Dev Cell 2015; 261-3. doi: 10.1016/j.devcel.2015.01.015

Leggi ora

Kumar R, Bach MP, Mainoldi F, Maruya M, Kishigami S, Jumaa H, Wakayama T, Kanagawa O, Fagarasan S, Casola S

Antibody repertoire diversification through VH gene replacement in mice cloned from an IgA plasma cell.

Proc Natl Acad Sci U S A 2015; E450-7. doi: 10.1073/pnas.1417988112

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Manfrini N, Trovesi C, Wery M, Martina M, Cesena D, Descrimes M, Morillon A, d'Adda di Fagagna F, Longhese MP

RNA-processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA.

EMBO Rep 2015; 221-31. doi: 10.15252/embr.201439458

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Malet-Engra G, Yu W, Oldani A, Rey-Barroso J, Gov NS, Scita G, Dupré L

Collective cell motility promotes chemotactic prowess and resistance to chemorepulsion.

Curr Biol 2015; 242-250. doi: 10.1016/j.cub.2014.11.030

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Gioia U, d'Adda di Fagagna F

Human nuclear ARGONAUTE 2 interacts in vivo only with small RNAs and not with DNA.

Cell Cycle 2015; 2001-2. doi: 10.1080/15384101.2015.1044171

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Corallino S, Malabarba MG, Zobel M, Di Fiore PP, Scita G

Epithelial-to-Mesenchymal Plasticity Harnesses Endocytic Circuitries.

Front Oncol 2015; 45. doi: 10.3389/fonc.2015.00045

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Cremaschi P, Oliverio M, Leva V, Bione S, Carriero R, Mazzucco G, Palamidessi A, Scita G, Biamonti G, Montecucco A

Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells.

PLoS One 2015; e0130561. doi: 10.1371/journal.pone.0130561

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Gay S, Foiani M

Nuclear envelope and chromatin, lock and key of genome integrity.

Int Rev Cell Mol Biol 2015; 267-330. doi: 10.1016/bs.ircmb.2015.03.001

Leggi ora

Hobor S, Van Emburgh BO, Crowley E, Misale S, Di Nicolantonio F, Bardelli A

TGFα and amphiregulin paracrine network promotes resistance to EGFR blockade in colorectal cancer cells.

Clin Cancer Res 2014; 6429-38. doi: 10.1158/1078-0432.CCR-14-0774

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Elgendy M, Ciro M, Abdel-Aziz AK, Belmonte G, Dal Zuffo R, Mercurio C, Miracco C, Lanfrancone L, Foiani M, Minucci S

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner.

Nat Commun 2014; 5637. doi: 10.1038/ncomms6637

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Matafora V, Zagato L, Ferrandi M, Molinari I, Zerbini G, Casamassima N, Lanzani C, Delli Carpini S, Trepiccione F, Manunta P, Bachi A, Capasso G

Quantitative proteomics reveals novel therapeutic and diagnostic markers in hypertension.

BBA Clin 2014; 79-87. doi: 10.1016/j.bbacli.2014.10.001

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Mari S, Ruetalo N, Maspero E, Stoffregen MC, Pasqualato S, Polo S, Wiesner S

Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases.

Structure 2014; 1639-49. doi: 10.1016/j.str.2014.09.006

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Misale S, Di Nicolantonio F, Sartore-Bianchi A, Siena S, Bardelli A

Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution.

Cancer Discov 2014; 1269-80. doi: 10.1158/2159-8290.CD-14-0462

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Crespo CL, Vernieri C, Keller PJ, Garrè M, Bender JR, Wittbrodt J, Pardi R

The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes.

J Cell Sci 2014; 4381-95. doi: 10.1242/jcs.146217

Leggi ora

Persaud A, Alberts P, Mari S, Tong J, Murchie R, Maspero E, Safi F, Moran MF, Polo S, Rotin D

Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity.

Sci Signal 2014; ra95. doi: 10.1126/scisignal.2005290

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Abe T, Branzei D

High levels of BRC4 induced by a Tet-On 3G system suppress DNA repair and impair cell proliferation in vertebrate cells.

DNA Repair (Amst) 2014; 153-64. doi: 10.1016/j.dnarep.2014.08.003

Leggi ora

Giannattasio M, Zwicky K, Follonier C, Foiani M, Lopes M, Branzei D

Visualization of recombination-mediated damage bypass by template switching.

Nat Struct Mol Biol 2014; 884-92. doi: 10.1038/nsmb.2888

Leggi ora

Van Emburgh BO, Sartore-Bianchi A, Di Nicolantonio F, Siena S, Bardelli A

Acquired resistance to EGFR-targeted therapies in colorectal cancer.

Mol Oncol 2014; 1084-94. doi: 10.1016/j.molonc.2014.05.003

Leggi ora

Lamba S, Russo M, Sun C, Lazzari L, Cancelliere C, Grernrum W, Lieftink C, Bernards R, Di Nicolantonio F, Bardelli A

RAF suppression synergizes with MEK inhibition in KRAS mutant cancer cells.

Cell Rep 2014; 1475-83. doi: 10.1016/j.celrep.2014.07.033

Leggi ora

Rolland Y, Marighetti P, Malinverno C, Confalonieri S, Luise C, Ducano N, Palamidessi A, Bisi S, Kajiho H, Troglio F, Shcherbakova OG, Dunn AR, Oldani A, Lanzetti L, Di Fiore PP, Disanza A, Scita G

The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination.

Dev Cell 2014; 553-68. doi: 10.1016/j.devcel.2014.08.006

Leggi ora

Kramarz K, Litwin I, Cal-Bąkowska M, Szakal B, Branzei D, Wysocki R, Dziadkowiec D

Swi2/Snf2-like protein Uls1 functions in the Sgs1-dependent pathway of maintenance of rDNA stability and alleviation of replication stress.

DNA Repair (Amst) 2014; 24-35. doi: 10.1016/j.dnarep.2014.05.008

Leggi ora

Simonetti G, Bertilaccio MT, Rodriguez TV, Apollonio B, Dagklis A, Rocchi M, Innocenzi A, Casola S, Winkler TH, Nitschke L, Ponzoni M, Caligaris-Cappio F, Ghia P

SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.

Haematologica 2014; 1356-64. doi: 10.3324/haematol.2013.100230

Leggi ora

Kumar A, Mazzanti M, Mistrik M, Kosar M, Beznoussenko GV, Mironov AA, Garrè M, Parazzoli D, Shivashankar GV, Scita G, Bartek J, Foiani M

ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress.

Cell 2014; 633-46. doi: 10.1016/j.cell.2014.05.046

Leggi ora

Frittoli E, Palamidessi A, Marighetti P, Confalonieri S, Bianchi F, Malinverno C, Mazzarol G, Viale G, Martin-Padura I, Garré M, Parazzoli D, Mattei V, Cortellino S, Bertalot G, Di Fiore PP, Scita G

A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination.

J Cell Biol 2014; 307-28. doi: 10.1083/jcb.201403127

Leggi ora

Gritenaite D, Princz LN, Szakal B, Bantele SC, Wendeler L, Schilbach S, Habermann BH, Matos J, Lisby M, Branzei D, Pfander B

A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication.

Genes Dev 2014; 1604-19. doi: 10.1101/gad.240515.114

Leggi ora

Cazzalini O, Sommatis S, Tillhon M, Dutto I, Bachi A, Rapp A, Nardo T, Scovassi AI, Necchi D, Cardoso MC, Stivala LA, Prosperi E

CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis.

Nucleic Acids Res 2014; 8433-48. doi: 10.1093/nar/gku533

Leggi ora

Boissan M, Montagnac G, Shen Q, Griparic L, Guitton J, Romao M, Sauvonnet N, Lagache T, Lascu I, Raposo G, Desbourdes C, Schlattner U, Lacombe ML, Polo S, van der Bliek AM, Roux A, Chavrier P

Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling.

Science 2014; 1510-5. doi: 10.1126/science.1253768

Leggi ora

Esposito A, Bardelli A, Criscitiello C, Colombo N, Gelao L, Fumagalli L, Minchella I, Locatelli M, Goldhirsch A, Curigliano G

Monitoring tumor-derived cell-free DNA in patients with solid tumors: clinical perspectives and research opportunities.

Cancer Treat Rev 2014; 648-55. doi: 10.1016/j.ctrv.2013.10.003

Leggi ora

Ogrunc M, Di Micco R, Liontos M, Bombardelli L, Mione M, Fumagalli M, Gorgoulis VG, d'Adda di Fagagna F

Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation.

Cell Death Differ 2014; 998-1012. doi: 10.1038/cdd.2014.16

Leggi ora

Rossiello F, Herbig U, Longhese MP, Fumagalli M, d'Adda di Fagagna F

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing.

Curr Opin Genet Dev 2014; 89-95. doi: 10.1016/j.gde.2014.06.009

Leggi ora

Siravegna G, Bardelli A

Minimal residual disease in breast cancer: in blood veritas.

Clin Cancer Res 2014; 2505-7. doi: 10.1158/1078-0432.CCR-14-0370

Leggi ora

Raule M, Cerruti F, Benaroudj N, Migotti R, Kikuchi J, Bachi A, Navon A, Dittmar G, Cascio P

PA28αβ reduces size and increases hydrophilicity of 20S immunoproteasome peptide products.

Chem Biol 2014; 470-480. doi: 10.1016/j.chembiol.2014.02.006

Leggi ora

Piunti A, Rossi A, Cerutti A, Albert M, Jammula S, Scelfo A, Cedrone L, Fragola G, Olsson L, Koseki H, Testa G, Casola S, Helin K, d'Adda di Fagagna F, Pasini D

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication.

Nat Commun 2014; 3649. doi: 10.1038/ncomms4649

Leggi ora

Sun C, Hobor S, Bertotti A, Zecchin D, Huang S, Galimi F, Cottino F, Prahallad A, Grernrum W, Tzani A, Schlicker A, Wessels LF, Smit EF, Thunnissen E, Halonen P, Lieftink C, Beijersbergen RL, Di Nicolantonio F, Bardelli A, Trusolino L, Bernards R

Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.

Cell Rep 2014; 86-93. doi: 10.1016/j.celrep.2014.02.045

Leggi ora

Sun C, Wang L, Huang S, Heynen GJ, Prahallad A, Robert C, Haanen J, Blank C, Wesseling J, Willems SM, Zecchin D, Hobor S, Bajpe PK, Lieftink C, Mateus C, Vagner S, Grernrum W, Hofland I, Schlicker A, Wessels LF, Beijersbergen RL, Bardelli A, Di Nicolantonio F, Eggermont AM, Bernards R

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma.

Nature 2014; 118-22. doi: 10.1038/nature13121

Leggi ora

d'Adda di Fagagna F

A direct role for small non-coding RNAs in DNA damage response.

Trends Cell Biol 2014; 171-8. doi: 10.1016/j.tcb.2013.09.008

Leggi ora

Gonzalez-Huici V, Szakal B, Urulangodi M, Psakhye I, Castellucci F, Menolfi D, Rajakumara E, Fumasoni M, Bermejo R, Jentsch S, Branzei D

DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity.

EMBO J 2014; 327-40. doi: 10.1002/embj.201387425

Leggi ora

Foiani M, Bartek J

Golgi feels DNA's pain.

Cell 2014; 392-3. doi: 10.1016/j.cell.2014.01.030

Leggi ora

Russo M, Di Nicolantonio F, Bardelli A

Climbing RAS, the everest of oncogenes.

Cancer Discov 2014; 19-21. doi: 10.1158/2159-8290.CD-13-0906

Leggi ora

Fumagalli M, Rossiello F, Mondello C, d'Adda di Fagagna F

Stable cellular senescence is associated with persistent DDR activation.

PLoS One 2014; e110969. doi: 10.1371/journal.pone.0110969

Leggi ora

Achar YJ, Foiani M

Dangerous liaisons: MYCN meets condensins.

Cell Cycle 2014; 1225-6. doi: 10.4161/cc.28569

Leggi ora

Polo S, Di Fiore PP, Sigismund S

Keeping EGFR signaling in check: ubiquitin is the guardian.

Cell Cycle 2014; 681-2. doi: 10.4161/cc.27855

Leggi ora

Palazzo L, Della Monica R, Visconti R, Costanzo V, Grieco D

ATM controls proper mitotic spindle structure.

Cell Cycle 2014; 1091-100. doi: 10.4161/cc.27945

Leggi ora

Errico A, Aze A, Costanzo V

Mta2 promotes Tipin-dependent maintenance of replication fork integrity.

Cell Cycle 2014; 2120-8. doi: 10.4161/cc.29157

Leggi ora

D'Antonio M, Guerra RF, Cereda M, Marchesi S, Montani F, Nicassio F, Di Fiore PP, Ciccarelli FD

Recessive cancer genes engage in negative genetic interactions with their functional paralogs.

Cell Rep 2013; 1519-26. doi: 10.1016/j.celrep.2013.11.033

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Palamidessi A, Frittoli E, Ducano N, Offenhauser N, Sigismund S, Kajiho H, Parazzoli D, Oldani A, Gobbi M, Serini G, Di Fiore PP, Scita G, Lanzetti L

The GTPase-activating protein RN-tre controls focal adhesion turnover and cell migration.

Curr Biol 2013; 2355-64. doi: 10.1016/j.cub.2013.09.060

Leggi ora

Disanza A, Bisi S, Winterhoff M, Milanesi F, Ushakov DS, Kast D, Marighetti P, Romet-Lemonne G, Müller HM, Nickel W, Linkner J, Waterschoot D, Ampè C, Cortellino S, Palamidessi A, Dominguez R, Carlier MF, Faix J, Scita G