Il nostro contributo

L’impatto scientifico misura l’influenza e la rilevanza delle scoperte e delle pubblicazioni di un istituto di ricerca. Per IFOM, l’impatto scientifico non si limita solo alla quantità di pubblicazioni, ma si estende alla qualità delle riviste su cui vengono pubblicati i nostri studi, alla visibilità dei nostri risultati e alla capacità di trasformare queste scoperte in avanzamenti concreti nella lotta contro il cancro.

Filtri

Anno

Autore

Publication type

Journal

Pal K, Tagliaferri I, Livi CM, Ferrari F

HiCBricks: building blocks for efficient handling of large Hi-C datasets.

Bioinformatics 2019; 1917-9. doi: 10.1093/bioinformatics/btz808

Leggi ora

Palamidessi A, Malinverno C, Frittoli E, Corallino S, Barbieri E, Sigismund S, Beznoussenko GV, Martini E, Garre M, Ferrara I, Tripodo C, Ascione F, Cavalcanti-Adam EA, Li Q, Di Fiore PP, Parazzoli D, Giavazzi F, Cerbino R, Scita G

Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma.

Nat Mater 2019; 1252-1263. doi: 10.1038/s41563-019-0425-1

Leggi ora

Crisafulli G, Mussolin B, Cassingena A, Montone M, Bartolini A, Barault L, Martinetti A, Morano F, Pietrantonio F, Sartore-Bianchi A, Siena S, Di Nicolantonio F, Marsoni S, Bardelli A, Siravegna G

Whole exome sequencing analysis of urine trans-renal tumour DNA in metastatic colorectal cancer patients.

ESMO Open 2019; . doi: 10.1136/esmoopen-2019-000572

Leggi ora

Biancospino M, Buel GR, Niño CA, Maspero E, Scotto di Perrotolo R, Raimondi A, Redlingshöfer L, Weber J, Brodsky FM, Walters KJ, Polo S

Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension.

Nat Commun 2019; 4974. doi: 10.1038/s41467-019-12855-6

Leggi ora

Pessina F, Giavazzi F, Yin Y, Gioia U, Vitelli V, Galbiati A, Barozzi S, Garre M, Oldani A, Flaus A, Cerbino R, Parazzoli D, Rothenberg E, d'Adda di Fagagna F

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors.

Nat Cell Biol 2019; 1286-1299. doi: 10.1038/s41556-019-0392-4

Leggi ora

Sartore-Bianchi A, Amatu A, Porcu L, Ghezzi S, Lonardi S, Leone F, Bergamo F, Fenocchio E, Martinelli E, Borelli B, Tosi F, Racca P, Valtorta E, Bonoldi E, Martino C, Vaghi C, Marrapese G, Ciardiello F, Zagonel V, Bardelli A, Trusolino L, Torri V, Marsoni S, Siena S

HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer.

Oncologist 2019; 1395-1402. doi: 10.1634/theoncologist.2018-0785

Leggi ora

Siravegna G, Mussolin B, Venesio T, Marsoni S, Seoane J, Dive C, Papadopoulos N, Kopetz S, Corcoran RB, Siu LL, Bardelli A

How liquid biopsies can change clinical practice in oncology.

Ann Oncol 2019; 1580-1590. doi: 10.1093/annonc/mdz227

Leggi ora

Sartore-Bianchi A, Marsoni S, Siena S

The Amount of Evidence Needed to Support ERBB2 as a Biomarker for Resistance to EGFR Inhibitors in Metastatic Colorectal Cancer.

JAMA Oncol 2019; 1510-1511. doi: 10.1001/jamaoncol.2019.2982

Leggi ora

Di Napoli A, Remotti D, Agostinelli C, Ambrosio MR, Ascani S, Carbone A, Facchetti F, Lazzi S, Leoncini L, Lucioni M, Novero D, Pileri S, Ponzoni M, Sabattini E, Tripodo C, Zamò A, Paulli M, Ruco L

A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matching clinical benefit : A position paper from the Italian Group of Haematopathology (G.I.E.).

Virchows Arch 2019; 513-518. doi: 10.1007/s00428-019-02637-2

Leggi ora

Totaro A, Zhuang Q, Panciera T, Battilana G, Azzolin L, Brumana G, Gandin A, Brusatin G, Cordenonsi M, Piccolo S

Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction.

Proc Natl Acad Sci U S A 2019; 17848-17857. doi: 10.1073/pnas.1908228116

Leggi ora

Niño CA, Sala S, Polo S

When ubiquitin meets E-cadherin: Plasticity of the epithelial cellular barrier.

Semin Cell Dev Biol 2019; 136-144. doi: 10.1016/j.semcdb.2018.12.005

Leggi ora

Smith RJ, Cordeiro MH, Davey NE, Vallardi G, Ciliberto A, Gross F, Saurin AT

PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore.

Cell Rep 2019; 2206-2219.e8. doi: 10.1016/j.celrep.2019.07.067

Leggi ora

Disanza A, Bisi S, Frittoli E, Malinverno C, Marchesi S, Palamidessi A, Rizvi A, Scita G

Is cell migration a selectable trait in the natural evolution of cancer development?

Philos Trans R Soc Lond B Biol Sci 2019; 20180224. doi: 10.1098/rstb.2018.0224

Leggi ora

Sicari D, Fantuz M, Bellazzo A, Valentino E, Apollonio M, Pontisso I, Di Cristino F, Dal Ferro M, Bicciato S, Del Sal G, Collavin L

Mutant p53 improves cancer cells' resistance to endoplasmic reticulum stress by sustaining activation of the UPR regulator ATF6.

Oncogene 2019; 6184-6195. doi: 10.1038/s41388-019-0878-3

Leggi ora

Zanconato F, Cordenonsi M, Piccolo S

YAP and TAZ: a signalling hub of the tumour microenvironment.

Nat Rev Cancer 2019; 454-464. doi: 10.1038/s41568-019-0168-y

Leggi ora

Nepravishta R, Ferrentino F, Mandaliti W, Mattioni A, Weber J, Polo S, Castagnoli L, Cesareni G, Paci M, Santonico E

CoCUN, a Novel Ubiquitin Binding Domain Identified in N4BP1.

Biomolecules 2019; . doi: 10.3390/biom9070284

Leggi ora

Wagner W, Lippmann K, Heisler FF, Gromova KV, Lombino FL, Roesler MK, Pechmann Y, Hornig S, Schweizer M, Polo S, Schwarz JR, Eilers J, Kneussel M

Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.

Cell Rep 2019; 11-20.e9. doi: 10.1016/j.celrep.2019.06.005

Leggi ora

D'Aniello C, Cermola F, Palamidessi A, Wanderlingh LG, Gagliardi M, Migliaccio A, Varrone F, Casalino L, Matarazzo MR, De Cesare D, Scita G, Patriarca EJ, Minchiotti G

Collagen Prolyl Hydroxylation-Dependent Metabolic Perturbation Governs Epigenetic Remodeling and Mesenchymal Transition in Pluripotent and Cancer Cells.

Cancer Res 2019; 3235-3250. doi: 10.1158/0008-5472.CAN-18-2070

Leggi ora

Pocaterra A, Santinon G, Romani P, Brian I, Dimitracopoulos A, Ghisleni A, Carnicer-Lombarte A, Forcato M, Braghetta P, Montagner M, Galuppini F, Aragona M, Pennelli G, Bicciato S, Gauthier N, Franze K, Dupont S

F-actin dynamics regulates mammalian organ growth and cell fate maintenance.

J Hepatol 2019; 130-142. doi: 10.1016/j.jhep.2019.02.022

Leggi ora

Vernieri C, Milano M, Brambilla M, Mennitto A, Maggi C, Cona MS, Prisciandaro M, Fabbroni C, Celio L, Mariani G, Bianchi GV, Capri G, de Braud F

Resistance mechanisms to anti-HER2 therapies in HER2-positive breast cancer: Current knowledge, new research directions and therapeutic perspectives.

Crit Rev Oncol Hematol 2019; 53-66. doi: 10.1016/j.critrevonc.2019.05.001

Leggi ora

Rospo G, Lorenzato A, Amirouchene-Angelozzi N, Magrì A, Cancelliere C, Corti G, Negrino C, Amodio V, Montone M, Bartolini A, Barault L, Novara L, Isella C, Medico E, Bertotti A, Trusolino L, Germano G, Di Nicolantonio F, Bardelli A

Evolving neoantigen profiles in colorectal cancers with DNA repair defects.

Genome Med 2019; 42. doi: 10.1186/s13073-019-0654-6

Leggi ora

Colombo A, Fontani M, Dragonetti C, Roberto D, Williams JAG, Scotto di Perrotolo R, Casagrande F, Barozzi S, Polo S

A Highly Luminescent Tetrahydrocurcumin IrIII Complex with Remarkable Photoactivated Anticancer Activity.

Chemistry 2019; 7948-7952. doi: 10.1002/chem.201901527

Leggi ora

Pascolutti R, Algisi V, Conte A, Raimondi A, Pasham M, Upadhyayula S, Gaudin R, Maritzen T, Barbieri E, Caldieri G, Tordonato C, Confalonieri S, Freddi S, Malabarba MG, Maspero E, Polo S, Tacchetti C, Haucke V, Kirchhausen T, Di Fiore PP, Sigismund S

Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling.

Cell Rep 2019; 3049-3061.e6. doi: 10.1016/j.celrep.2019.05.017

Leggi ora

Farina F, Ramkumar N, Brown L, Samandar Eweis D, Anstatt J, Waring T, Bithell J, Scita G, Thery M, Blanchoin L, Zech T, Baum B

Local actin nucleation tunes centrosomal microtubule nucleation during passage through mitosis.

EMBO J 2019; . doi: 10.15252/embj.201899843

Leggi ora

Corti G, Bartolini A, Crisafulli G, Novara L, Rospo G, Montone M, Negrino C, Mussolin B, Buscarino M, Isella C, Barault L, Siravegna G, Siena S, Marsoni S, Di Nicolantonio F, Medico E, Bardelli A

A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology.

Clin Colorectal Cancer 2019; 91-101.e3. doi: 10.1016/j.clcc.2019.02.008

Leggi ora

Siravegna G, Sartore-Bianchi A, Nagy RJ, Raghav K, Odegaard JI, Lanman RB, Trusolino L, Marsoni S, Siena S, Bardelli A

Plasma HER2 (ERBB2) Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer.

Clin Cancer Res 2019; 3046-3053. doi: 10.1158/1078-0432.CCR-18-3389

Leggi ora

Elgendy M, Cirò M, Hosseini A, Weiszmann J, Mazzarella L, Ferrari E, Cazzoli R, Curigliano G, DeCensi A, Bonanni B, Budillon A, Pelicci PG, Janssens V, Ogris M, Baccarini M, Lanfrancone L, Weckwerth W, Foiani M, Minucci S

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis.

Cancer Cell 2019; 798-815.e5. doi: 10.1016/j.ccell.2019.03.007

Leggi ora

Michelini F, Rossiello F, d'Adda di Fagagna F, Francia S

RNase A treatment and reconstitution with DNA damage response RNA in living cells as a tool to study the role of non-coding RNA in the formation of DNA damage response foci.

Nat Protoc 2019; 1489-1508. doi: 10.1038/s41596-019-0147-5

Leggi ora

Vernieri C, Signorelli D, Galli G, Ganzinelli M, Moro M, Fabbri A, Tamborini E, Marabese M, Caiola E, Broggini M, Hollander L, Gallucci R, Vandoni G, Gavazzi C, Triulzi T, Colombo MP, Rizzo AM, Corsetto PA, Pruneri G, de Braud F, Sozzi G, Torri V, Garassino MC

Exploiting FAsting-mimicking Diet and MEtformin to Improve the Efficacy of Platinum-pemetrexed Chemotherapy in Advanced LKB1-inactivated Lung Adenocarcinoma: The FAME Trial.

Clin Lung Cancer 2019; e413-e417. doi: 10.1016/j.cllc.2018.12.011

Leggi ora

Doksani Y

The Response to DNA Damage at Telomeric Repeats and Its Consequences for Telomere Function.

Genes (Basel) 2019; . doi: 10.3390/genes10040318

Leggi ora

Gioia U, Francia S, Cabrini M, Brambillasca S, Michelini F, Jones-Weinert CW, d'Adda di Fagagna F

Pharmacological boost of DNA damage response and repair by enhanced biogenesis of DNA damage response RNAs.

Sci Rep 2019; 6460. doi: 10.1038/s41598-019-42892-6

Leggi ora

Travelli C, Consonni FM, Sangaletti S, Storto M, Morlacchi S, Grolla AA, Galli U, Tron GC, Portararo P, Rimassa L, Pressiani T, Mazzone M, Trovato R, Ugel S, Bronte V, Tripodo C, Colombo MP, Genazzani AA, Sica A

Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells.

Cancer Res 2019; 1938-1951. doi: 10.1158/0008-5472.CAN-18-1544

Leggi ora

Pozzi G, Marchesi S, Scita G, Ambrosi D, Ciarletta P

Mechano-biological model of glioblastoma cells in response to osmotic stress.

Math Biosci Eng 2019; 2795-2810. doi: 10.3934/mbe.2019139

Leggi ora

Vernieri C, Pusceddu S, Fucà G, Indelicato P, Centonze G, Castagnoli L, Ferrari E, Ajazi A, Pupa S, Casola S, Foiani M, Mazzaferro V, Pruneri G, Milione M, de Braud F

Impact of systemic and tumor lipid metabolism on everolimus efficacy in advanced pancreatic neuroendocrine tumors (pNETs).

Int J Cancer 2019; 1704-1712. doi: 10.1002/ijc.32042

Leggi ora

Vernieri C, Prisciandaro M, Milano M, Cona MS, Maggi C, Brambilla M, Mennitto A, Fabbroni C, Farè E, Cresta S, Celio L, Mariani G, Bianchi G, Capri G, de Braud F

Single-Agent Gemcitabine vs. Carboplatin-Gemcitabine in Advanced Breast Cancer: A Retrospective Comparison of Efficacy and Safety Profiles.

Clin Breast Cancer 2019; e306-e318. doi: 10.1016/j.clbc.2018.12.004

Leggi ora

Bertolio R, Napoletano F, Mano M, Maurer-Stroh S, Fantuz M, Zannini A, Bicciato S, Sorrentino G, Del Sal G

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism.

Nat Commun 2019; 1326. doi: 10.1038/s41467-019-09152-7

Leggi ora

Barger SR, Reilly NS, Shutova MS, Li Q, Maiuri P, Heddleston JM, Mooseker MS, Flavell RA, Svitkina T, Oakes PW, Krendel M, Gauthier NC

Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis.

Nat Commun 2019; 1249. doi: 10.1038/s41467-019-09104-1

Leggi ora

Gallo D, Kim T, Szakal B, Saayman X, Narula A, Park Y, Branzei D, Zhang Z, Brown GW

Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates.

Mol Cell 2019; 900-914.e9. doi: 10.1016/j.molcel.2019.01.001

Leggi ora

Achar YJ, Foiani M

An Error-Prone Polymerase in the Fight against Cancer.

Cell 2019; 1241-1243. doi: 10.1016/j.cell.2019.02.011

Leggi ora

Teza G, Suweis S, Gherardi M, Maritan A, Cosentino Lagomarsino M

Network model of conviction-driven social segregation.

Phys Rev E 2019; 032310. doi: 10.1103/PhysRevE.99.032310

Leggi ora

Casola S, Perucho L, Tripodo C, Sindaco P, Ponzoni M, Facchetti F

The B-cell receptor in control of tumor B-cell fitness: Biology and clinical relevance.

Immunol Rev 2019; 198-213. doi: 10.1111/imr.12738

Leggi ora

Giannattasio M, Branzei D

DNA Replication Through Strand Displacement During Lagging Strand DNA Synthesis in Saccharomyces cerevisiae.

Genes (Basel) 2019; . doi: 10.3390/genes10020167

Leggi ora

Cona MS, Lecchi M, Cresta S, Damian S, Del Vecchio M, Necchi A, Poggi MM, Raggi D, Randon G, Ratta R, Signorelli D, Vernieri C, de Braud F, Verderio P, Di Nicola M

Combination of Baseline LDH, Performance Status and Age as Integrated Algorithm to Identify Solid Tumor Patients with Higher Probability of Response to Anti PD-1 and PD-L1 Monoclonal Antibodies.

Cancers (Basel) 2019; . doi: 10.3390/cancers11020223

Leggi ora

Zucchelli C, Tamburri S, Filosa G, Ghitti M, Quilici G, Bachi A, Musco G

Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent Bromodomain.

Biochim Biophys Acta Gen Subj 2019; 456-465. doi: 10.1016/j.bbagen.2018.11.011

Leggi ora

Pal K, Forcato M, Ferrari F

Hi-C analysis: from data generation to integration.

Biophys Rev 2019; 67-78. doi: 10.1007/s12551-018-0489-1

Leggi ora

Lo Russo G, Moro M, Sommariva M, Cancila V, Boeri M, Centonze G, Ferro S, Ganzinelli M, Gasparini P, Huber V, Milione M, Porcu L, Proto C, Pruneri G, Signorelli D, Sangaletti S, Sfondrini L, Storti C, Tassi E, Bardelli A, Marsoni S, Torri V, Tripodo C, Colombo MP, Anichini A, Rivoltini L, Balsari A, Sozzi G, Garassino MC

Antibody-Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non-small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade.

Clin Cancer Res 2019; 989-999. doi: 10.1158/1078-0432.CCR-18-1390

Leggi ora

Mauri G, Sartore-Bianchi A, Russo AG, Marsoni S, Bardelli A, Siena S

Early-onset colorectal cancer in young individuals.

Mol Oncol 2019; 109-131. doi: 10.1002/1878-0261.12417

Leggi ora

Mauri G, Pizzutilo EG, Amatu A, Bencardino K, Palmeri L, Bonazzina EF, Tosi F, Carlo Stella G, Burrafato G, Scaglione F, Marsoni S, Siravegna G, Bardelli A, Siena S, Sartore-Bianchi A