Il nostro contributo

L’impatto scientifico misura l’influenza e la rilevanza delle scoperte e delle pubblicazioni di un istituto di ricerca. Per IFOM, l’impatto scientifico non si limita solo alla quantità di pubblicazioni, ma si estende alla qualità delle riviste su cui vengono pubblicati i nostri studi, alla visibilità dei nostri risultati e alla capacità di trasformare queste scoperte in avanzamenti concreti nella lotta contro il cancro.

Osti D, Del Bene M, Rappa G, Santos M, Matafora V, Richichi C, Faletti S, Beznoussenko GV, Mironov A, Bachi A, Fornasari L, Bongetta D, Gaetani P, DiMeco F, Lorico A, Pelicci G

Clinical Significance of Extracellular Vesicles in Plasma from Glioblastoma Patients.

Clin Cancer Res 2019; 266-276. doi: 10.1158/1078-0432.CCR-18-1941

Mantovani F, Collavin L, Del Sal G

Mutant p53 as a guardian of the cancer cell.

Cell Death Differ 2019; 199-212. doi: 10.1038/s41418-018-0246-9

Ardelt MA, Fröhlich T, Martini E, Müller M, Kanitz V, Atzberger C, Cantonati P, Meßner M, Posselt L, Lehr T, Wojtyniak JG, Ulrich M, Arnold GJ, König L, Parazzoli D, Zahler S, Rothenfußer S, Mayr D, Gerbes A, Scita G, Vollmar AM, Pachmayr J

Inhibition of Cyclin-Dependent Kinase 5: A Strategy to Improve Sorafenib Response in Hepatocellular Carcinoma Therapy.

Hepatology 2019; 376-393. doi: 10.1002/hep.30190

Martano G, Borroni EM, Lopci E, Cattaneo MG, Mattioli M, Bachi A, Decimo I, Bifari F

Metabolism of Stem and Progenitor Cells: Proper Methods to Answer Specific Questions.

Front Mol Neurosci 2019; 151. doi: 10.3389/fnmol.2019.00151

Zannini A, Rustighi A, Campaner E, Del Sal G

Oncogenic Hijacking of the PIN1 Signaling Network.

Front Oncol 2019; 94. doi: 10.3389/fonc.2019.00094

Amatu A, Schirripa M, Tosi F, Lonardi S, Bencardino K, Bonazzina E, Palmeri L, Patanè DA, Pizzutilo EG, Mussolin B, Bergamo F, Alberti G, Intini R, Procaccio L, Arese M, Marsoni S, Nichelatti M, Zagonel V, Siena S, Bardelli A, Loupakis F, Di Nicolantonio F, Sartore-Bianchi A, Barault L

High Circulating Methylated DNA Is a Negative Predictive and Prognostic Marker in Metastatic Colorectal Cancer Patients Treated With Regorafenib.

Front Oncol 2019; 622. doi: 10.3389/fonc.2019.00622

Fucà G, Galli G, Poggi M, Lo Russo G, Proto C, Imbimbo M, Ferrara R, Zilembo N, Ganzinelli M, Sica A, Torri V, Colombo MP, Vernieri C, Balsari A, de Braud F, Garassino MC, Signorelli D

Modulation of peripheral blood immune cells by early use of steroids and its association with clinical outcomes in patients with metastatic non-small cell lung cancer treated with immune checkpoint inhibitors.

ESMO Open 2019; e000457. doi: 10.1136/esmoopen-2018-000457

D'Alessandro G, Whelan DR, Howard SM, Vitelli V, Renaudin X, Adamowicz M, Iannelli F, Jones-Weinert CW, Lee M, Matti V, Lee WTC, Morten MJ, Venkitaraman AR, Cejka P, Rothenberg E, d'Adda di Fagagna F

BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment.

Nat Commun 2018; 5376. doi: 10.1038/s41467-018-07799-2

Gaviraghi M, Vivori C, Pareja Sanchez Y, Invernizzi F, Cattaneo A, Santoliquido BM, Frenquelli M, Segalla S, Bachi A, Doglioni C, Pelechano V, Cittaro D, Tonon G

Tumor suppressor PNRC1 blocks rRNA maturation by recruiting the decapping complex to the nucleolus.

EMBO J 2018; . doi: 10.15252/embj.201899179

De Santis F, Del Vecchio M, Castagnoli L, De Braud F, Di Cosimo S, Franceschini D, Fucà G, Hiscott J, Malmberg KJ, McGranahan N, Pietrantonio F, Rivoltini L, Sangaletti S, Tagliabue E, Tripodo C, Vernieri C, Zitvogel L, Pupa SM, Di Nicola M

Innovative therapy, monoclonal antibodies, and beyond: Highlights from the eighth annual meeting.

Cytokine Growth Factor Rev 2018; 1-10. doi: 10.1016/j.cytogfr.2018.10.005

Barault L, Amatu A, Siravegna G, Ponzetti A, Moran S, Cassingena A, Mussolin B, Falcomatà C, Binder AM, Cristiano C, Oddo D, Guarrera S, Cancelliere C, Bustreo S, Bencardino K, Maden S, Vanzati A, Zavattari P, Matullo G, Truini M, Grady WM, Racca P, Michels KB, Siena S, Esteller M, Bardelli A, Sartore-Bianchi A, Di Nicolantonio F

Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer.

Gut 2018; 1995-2005. doi: 10.1136/gutjnl-2016-313372

Micali G, Grilli J, Osella M, Cosentino Lagomarsino M

Concurrent processes set E. coli cell division.

Sci Adv 2018; eaau3324. doi: 10.1126/sciadv.aau3324

Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, Sigismondo G, Krijgsveld J, Fassan M, Brusatin G, Cordenonsi M, Piccolo S

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ.

Nature 2018; 265-269. doi: 10.1038/s41586-018-0658-1

Moro M, Caiola E, Ganzinelli M, Zulato E, Rulli E, Marabese M, Centonze G, Busico A, Pastorino U, de Braud FG, Vernieri C, Simbolo M, Bria E, Scarpa A, Indraccolo S, Broggini M, Sozzi G, Garassino MC

Metformin Enhances Cisplatin-Induced Apoptosis and Prevents Resistance to Cisplatin in Co-mutated KRAS/LKB1 NSCLC.

J Thorac Oncol 2018; 1692-1704. doi: 10.1016/j.jtho.2018.07.102

Brummelman J, Mazza EMC, Alvisi G, Colombo FS, Grilli A, Mikulak J, Mavilio D, Alloisio M, Ferrari F, Lopci E, Novellis P, Veronesi G, Lugli E

High-dimensional single cell analysis identifies stem-like cytotoxic CD8+ T cells infiltrating human tumors.

J Exp Med 2018; 2520-2535. doi: 10.1084/jem.20180684

Zanconato F, Battilana G, Forcato M, Filippi L, Azzolin L, Manfrin A, Quaranta E, Di Biagio D, Sigismondo G, Guzzardo V, Lejeune P, Haendler B, Krijgsveld J, Fassan M, Bicciato S, Cordenonsi M, Piccolo S

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4.

Nat Med 2018; 1599-1610. doi: 10.1038/s41591-018-0158-8

Iacovella MG, Bremang M, Basha O, Giacò L, Carotenuto W, Golfieri C, Szakal B, Dal Maschio M, Infantino V, Beznoussenko GV, Joseph CR, Visintin C, Mironov AA, Visintin R, Branzei D, Ferreira-Cerca S, Yeger-Lotem E, De Wulf P

Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae.

Nucleic Acids Res 2018; 7586-7611. doi: 10.1093/nar/gky618

Zobel M, Disanza A, Senic-Matuglia F, Franco M, Colaluca IN, Confalonieri S, Bisi S, Barbieri E, Caldieri G, Sigismund S, Pece S, Chavrier P, Di Fiore PP, Scita G

A NUMB-EFA6B-ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility.

J Cell Biol 2018; 3161-3182. doi: 10.1083/jcb.201802023

Copenhagen K, Malet-Engra G, Yu W, Scita G, Gov N, Gopinathan A

Frustration-induced phases in migrating cell clusters.

Sci Adv 2018; eaar8483. doi: 10.1126/sciadv.aar8483

Cadart C, Monnier S, Grilli J, Sáez PJ, Srivastava N, Attia R, Terriac E, Baum B, Cosentino-Lagomarsino M, Piel M

Size control in mammalian cells involves modulation of both growth rate and cell cycle duration.

Nat Commun 2018; 3275. doi: 10.1038/s41467-018-05393-0

Abe T, Kawasumi R, Giannattasio M, Dusi S, Yoshimoto Y, Miyata K, Umemura K, Hirota K, Branzei D

AND-1 fork protection function prevents fork resection and is essential for proliferation.

Nat Commun 2018; 3091. doi: 10.1038/s41467-018-05586-7

Pusceddu S, Vernieri C, Di Maio M, Marconcini R, Spada F, Massironi S, Ibrahim T, Brizzi MP, Campana D, Faggiano A, Giuffrida D, Rinzivillo M, Cingarlini S, Aroldi F, Antonuzzo L, Berardi R, Catena L, De Divitiis C, Ermacora P, Perfetti V, Fontana A, Razzore P, Carnaghi C, Davì MV, Cauchi C, Duro M, Ricci S, Fazio N, Cavalcoli F, Bongiovanni A, La Salvia A, Brighi N, Colao A, Puliafito I, Panzuto F, Ortolani S, Zaniboni A, Di Costanzo F, Torniai M, Bajetta E, Tafuto S, Garattini SK, Femia D, Prinzi N, Concas L, Lo Russo G, Milione M, Giacomelli L, Buzzoni R, Delle Fave G, Mazzaferro V, de Braud F

Metformin Use Is Associated With Longer Progression-Free Survival of Patients With Diabetes and Pancreatic Neuroendocrine Tumors Receiving Everolimus and/or Somatostatin Analogues.

Gastroenterology 2018; 479-489.e7. doi: 10.1053/j.gastro.2018.04.010

Siravegna G, Lazzari L, Crisafulli G, Sartore-Bianchi A, Mussolin B, Cassingena A, Martino C, Lanman RB, Nagy RJ, Fairclough S, Rospo G, Corti G, Bartolini A, Arcella P, Montone M, Lodi F, Lorenzato A, Vanzati A, Valtorta E, Cappello G, Bertotti A, Lonardi S, Zagonel V, Leone F, Russo M, Balsamo A, Truini M, Di Nicolantonio F, Amatu A, Bonazzina E, Ghezzi S, Regge D, Vanzulli A, Trusolino L, Siena S, Marsoni S, Bardelli A

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer.

Cancer Cell 2018; 148-162.e7. doi: 10.1016/j.ccell.2018.06.004

Bharti SK, Sommers JA, Awate S, Bellani MA, Khan I, Bradley L, King GA, Seol Y, Vidhyasagar V, Wu Y, Abe T, Kobayashi K, Shin-Ya K, Kitao H, Wold MS, Branzei D, Neuman KC, Brosh RM

A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair.

Nucleic Acids Res 2018; 6238-6256. doi: 10.1093/nar/gky403

Mazzolini A, Grilli J, De Lazzari E, Osella M, Lagomarsino MC, Gherardi M

Zipf and Heaps laws from dependency structures in component systems.

Phys Rev E 2018; 012315. doi: 10.1103/PhysRevE.98.012315

Russo M, Lamba S, Lorenzato A, Sogari A, Corti G, Rospo G, Mussolin B, Montone M, Lazzari L, Arena S, Oddo D, Linnebacher M, Sartore-Bianchi A, Pietrantonio F, Siena S, Di Nicolantonio F, Bardelli A

Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies.

Nat Commun 2018; 2287. doi: 10.1038/s41467-018-04506-z

Vernieri C, Mennitto A, Prisciandaro M, Huber V, Milano M, Rinaldi L, Cona MS, Maggi C, Ferrari B, Manoukian S, Mariani G, Bianchi G, Capri G, Rivoltini L, de Braud F

The neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios predict efficacy of platinum-based chemotherapy in patients with metastatic triple negative breast cancer.

Sci Rep 2018; 8703. doi: 10.1038/s41598-018-27075-z

Agier N, Delmas S, Zhang Q, Fleiss A, Jaszczyszyn Y, van Dijk E, Thermes C, Weigt M, Cosentino-Lagomarsino M, Fischer G

The evolution of the temporal program of genome replication.

Nat Commun 2018; 2199. doi: 10.1038/s41467-018-04628-4

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