Il nostro contributo

L’impatto scientifico misura l’influenza e la rilevanza delle scoperte e delle pubblicazioni di un istituto di ricerca. Per IFOM, l’impatto scientifico non si limita solo alla quantità di pubblicazioni, ma si estende alla qualità delle riviste su cui vengono pubblicati i nostri studi, alla visibilità dei nostri risultati e alla capacità di trasformare queste scoperte in avanzamenti concreti nella lotta contro il cancro.

Marchesi S, Guidolin C, Massey AE, Lemahieu G, Lavagnino Z, Beznoussenko GV, Mironov AA, Green BJ, Allievi E, Martini E, Magni S, Ghisleni A, Lomazzi C, Benvenuto AF, Schertel A, van Faassen DA, Freddi S, Bertalot G, Parazzoli D, Maiuri P, Mapelli M, Pece S, Sigismund S, Gauthier NC, Cavalcanti-Adam EA, Cartagena-Rivera AX, Giavazzi F, Scita G, Disanza A

Mechanisms of active wetting and fluidification in epithelial cell collectives.

Nat Mater 2026; . doi: 10.1038/s41563-026-02553-2

Fusilier Z, Clément A, Simon F, Calvente I, Jean-Marie R, Mathieu M, Calmettes V, Piastra-Facon F, Quintana-Perez Y, Clement JG, Crestey L, Lumineau E, Henninger R, Tonani M, Manriquez V, Lacerda Mariano L, Bensaid L, de Villemagne P, Piaggio E, Semetey V, Coscoy S, Martini E, Scita G, Gelly JC, Ivaska J, Isambert H, Goudot C, Pierobon P, Lennon-Duménil AM, Moreau HD

Macrophages restrict tumor immune infiltration by controlling collagen topography.

Sci Immunol 2026; eadw8291. doi: 10.1126/sciimmunol.adw8291

Totaro A, Zhuang Q, Panciera T, Battilana G, Azzolin L, Brumana G, Gandin A, Brusatin G, Cordenonsi M, Piccolo S

Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction.

Proc Natl Acad Sci U S A 2019; 17848-17857. doi: 10.1073/pnas.1908228116

Kaivola J, Punovuori K, Chastney MR, Abdo H, Follain G, Mathieu M, Joshi O, Miroshnikova YA, Krautgasser F, Di Franco J, Conway JRW, Held S, Bertillot F, Hagström J, Mäkitie A, Irjala H, Ventelä S, Hamidi H, Scita G, Cerbino R, Wickström SA, Ivaska J

Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties.

Nat Mater 2026; . doi: 10.1038/s41563-025-02473-7

Makkieh M, Passeri AA, Lazzari D, Marchesi S, Disanza A, Salem RKA, Bonacci F, Mazzella C, Martini E, Tonani M, Donati L, Bellini E, Abdo H, Pineau J, Magni S, Orsenigo F, Piel M, Fioretto D, Martino S, Mattarelli M, Scita G, Green BJ, Caponi S

Brillouin Microscopy of Breast tumor Spheroids On-a-Chip: Mechanical and Transcriptional Responses to Microfluidic-Induced Rapid Deformations.

Adv Sci (Weinh) 2026; e13153. doi: 10.1002/advs.202513153

Abdo H, Barzaghi L, Shen Y, Bellini E, Martini E, Magni S, Barozzi S, Orsenigo F, Parazzoli D, Beznoussenko GV, Franco JD, Krautgasser F, Kaivola J, Cinquanta M, Lazzarin A, Sigismund S, Ivaska J, Cerbino R, Scita G

De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems.

Adv Sci (Weinh) 2026; e08648. doi: 10.1002/advs.202508648

Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, Sigismondo G, Krijgsveld J, Fassan M, Brusatin G, Cordenonsi M, Piccolo S

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ.

Nature 2018; 265-269. doi: 10.1038/s41586-018-0658-1

Zanconato F, Battilana G, Forcato M, Filippi L, Azzolin L, Manfrin A, Quaranta E, Di Biagio D, Sigismondo G, Guzzardo V, Lejeune P, Haendler B, Krijgsveld J, Fassan M, Bicciato S, Cordenonsi M, Piccolo S

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4.

Nat Med 2018; 1599-1610. doi: 10.1038/s41591-018-0158-8

Panciera T, Azzolin L, Di Biagio D, Totaro A, Cordenonsi M, Piccolo S

De Novo Generation of Somatic Stem Cells by YAP/TAZ.

J Vis Exp 2018; . doi: 10.3791/57462

Bassetti F, Lagomarsino MC, Bassetti B, Jona P

Random networks tossing biased coins.

Phys Rev E Stat Nonlin Soft Matter Phys 2007; 056109. doi: 10.1103/PhysRevE.75.056109

Petti E, Di Vito S, Dinami R, Porru M, Marchesi S, Lohuis J, Zizza P, Iachettini S, Salvati E, D'Angelo C, Rizzo A, Maresca C, Ascione F, Di Benedetto A, Buglioni S, Sacconi A, Ostano P, Li Q, Stoppacciaro A, Leonetti C, van Rheenen J, Maiuri P, Scita G, Biroccio A

TRF2 interaction with nuclear envelope is required for cell polarization and metastasis in triple negative breast cancer.

Cell Death Dis 2025; 224. doi: 10.1038/s41419-025-07415-4

Marchesi S, Guidolin C, Massey AE, Lemahieu G, Lavagnino Z, Beznoussenko GV, Mironov AA, Green B, Allievi E, Martini E, Magni S, Ghisleni A, Lomazzi C, Benvenuto AF, Schertel A, Parazzoli D, Maiuri P, Sigismund S, Gauthier N, Cavalcanti-Adam AE, Cartagena-Rivera AX, Giavazzi F, Scita G, Disanza A

Biophysical and Molecular mechanisms that control active wetting and tissue fluidification in epithelial tissues.

Res Sq 2025; . doi: 10.21203/rs.3.rs-6008502/v1

Yui S, Azzolin L, Maimets M, Pedersen MT, Fordham RP, Hansen SL, Larsen HL, Guiu J, Alves MRP, Rundsten CF, Johansen JV, Li Y, Madsen CD, Nakamura T, Watanabe M, Nielsen OH, Schweiger PJ, Piccolo S, Jensen KB

YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration.

Cell Stem Cell 2018; 35-49.e7. doi: 10.1016/j.stem.2017.11.001

Masud W, Russo L, Chapdelaine-Trépanier V, Hayward SB, He W, Cirò M, Mercurio C, Xu H, Ciccia A, Cuella-Martin R, Leuzzi G

A base editing resource for functional annotation of DNA repair variants in breast-derived cell models.

Front Cell Dev Biol 2026; 1714494. doi: 10.3389/fcell.2026.1714494

Totaro A, Castellan M, Battilana G, Zanconato F, Azzolin L, Giulitti S, Cordenonsi M, Piccolo S

YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate.

Nat Commun 2017; 15206. doi: 10.1038/ncomms15206

Hayashi S, Morimoto M, Inomata H, Piccolo S

Size in development.

Dev Growth Differ 2017; 3. doi: 10.1111/dgd.12339

Panciera T, Azzolin L, Cordenonsi M, Piccolo S

Mechanobiology of YAP and TAZ in physiology and disease.

Nat Rev Mol Cell Biol 2017; 758-770. doi: 10.1038/nrm.2017.87

Scafetta R, Donato M, Gullotta C, Guarino A, Fiore C, Sisca L, Speziale E, Troiano R, Foderaro S, Venuti F, Vilardi FA, Ricozzi V, Iuliani M, Simonetti S, Cavaliere S, Cortellini A, La Cesa A, Botticelli A, Scagnoli S, Pisegna S, Criscitiello C, Chirco A, D'Alessandro S, Pedersini R, Sposetti C, Tiberi E, D'Auria G, Vergati M, Mazzotta M, Caputo R, Verrazzo A, Rossino MG, Domati F, Piombino C, Di Lisa FS, Filomeno L, Arcuri T, Puce F, Riva F, Palleschi M, Sirico M, Piras M, Stucci LS, De Lisi D, Orsaria P, Grasso A, Ippolito E, Ramella S, Visani L, Bertini N, Bonaparte I, Gori S, Rossi L, Meattini I, Tagliaferri B, Caffo O, Bonomo MV, Portarena I, Irelli A, Cretella E, Porta C, Bianchini G, Fabbri MA, De Giorgi U, Vici P, Toss A, Garrone O, De Laurentiis M, Villa F, Berardi R, Minelli M, Altomare V, Vernieri C, Curigliano G, Vincenzi B, Tonini G, Santini D, Pantano F

Comparative real-world progression free survival of CDK4/6 inhibitors in HR+/HER2- breast cancer patients with bone metastases.

Oncologist 2026; . doi: 10.1093/oncolo/oyag146

Kaivola J, Punovuori K, Chastney MR, Miroshnikova YA, Abdo H, Bertillot F, Krautgasser F, Franco JD, Conway JRW, Follain G, Hagström J, Mäkitie A, Irjala H, Ventelä S, Hamidi H, Scita G, Cerbino R, Wickström SA, Ivaska J

Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer.

bioRxiv 2024; . doi: 10.1101/2024.08.22.609159

Gritenaite D, Princz LN, Szakal B, Bantele SC, Wendeler L, Schilbach S, Habermann BH, Matos J, Lisby M, Branzei D, Pfander B

A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication.

Genes Dev 2014; 1604-19. doi: 10.1101/gad.240515.114

Panciera T, Azzolin L, Fujimura A, Di Biagio D, Frasson C, Bresolin S, Soligo S, Basso G, Bicciato S, Rosato A, Cordenonsi M, Piccolo S

Induction of Expandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZ.

Cell Stem Cell 2016; 725-737. doi: 10.1016/j.stem.2016.08.009

Mesa D, Barbieri E, Raimondi A, Freddi S, Miloro G, Jendrisek G, Caldieri G, Quarto M, Schiano Lomoriello I, Malabarba MG, Bresci A, Manetti F, Vernuccio F, Abdo H, Scita G, Lanzetti L, Polli D, Tacchetti C, Pinton P, Bonora M, Di Fiore PP, Sigismund S

A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism.

Nat Commun 2024; 5119. doi: 10.1038/s41467-024-49543-z

Zaccarin M, Bosello-Travain V, Di Paolo ML, Falda M, Maiorino M, Miotto G, Piccolo S, Roveri A, Ursini F, Venerando R, Toppo S

Redox status in a model of cancer stem cells.

Arch Biochem Biophys 2017; 120-128. doi: 10.1016/j.abb.2016.09.002

Zanconato F, Battilana G, Cordenonsi M, Piccolo S

YAP/TAZ as therapeutic targets in cancer.

Curr Opin Pharmacol 2016; 26-33. doi: 10.1016/j.coph.2016.05.002

Quiroga X, Walani N, Disanza A, Chavero A, Mittens A, Tebar F, Trepat X, Parton RG, Geli MI, Scita G, Arroyo M, Le Roux AL, Roca-Cusachs P

A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale.

Elife 2023; . doi: 10.7554/eLife.72316

Nowell CS, Odermatt PD, Azzolin L, Hohnel S, Wagner EF, Fantner GE, Lutolf MP, Barrandon Y, Piccolo S, Radtke F

Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction.

Nat Cell Biol 2016; 168-80. doi: 10.1038/ncb3290

Frittoli E, Palamidessi A, Iannelli F, Zanardi F, Villa S, Barzaghi L, Abdo H, Cancila V, Beznoussenko GV, Della Chiara G, Pagani M, Malinverno C, Bhattacharya D, Pisati F, Yu W, Galimberti V, Bonizzi G, Martini E, Mironov AA, Gioia U, Ascione F, Li Q, Havas K, Magni S, Lavagnino Z, Pennacchio FA, Maiuri P, Caponi S, Mattarelli M, Martino S, d'Adda di Fagagna F, Rossi C, Lucioni M, Tancredi R, Pedrazzoli P, Vecchione A, Petrini C, Ferrari F, Lanzuolo C, Bertalot G, Nader G, Foiani M, Piel M, Cerbino R, Giavazzi F, Tripodo C, Scita G

Tissue fluidification promotes a cGAS-STING cytosolic DNA response in invasive breast cancer.

Nat Mater 2023; 644-655. doi: 10.1038/s41563-022-01431-x

Gonzalez-Huici V, Szakal B, Urulangodi M, Psakhye I, Castellucci F, Menolfi D, Rajakumara E, Fumasoni M, Bermejo R, Jentsch S, Branzei D

DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity.

EMBO J 2014; 327-40. doi: 10.1002/embj.201387425

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