Il nostro contributo

L’impatto scientifico misura l’influenza e la rilevanza delle scoperte e delle pubblicazioni di un istituto di ricerca. Per IFOM, l’impatto scientifico non si limita solo alla quantità di pubblicazioni, ma si estende alla qualità delle riviste su cui vengono pubblicati i nostri studi, alla visibilità dei nostri risultati e alla capacità di trasformare queste scoperte in avanzamenti concreti nella lotta contro il cancro.

Capaci V, Bascetta L, Fantuz M, Beznoussenko GV, Sommaggio R, Cancila V, Bisso A, Campaner E, Mironov AA, Wiśniewski JR, Ulloa Severino L, Scaini D, Bossi F, Lees J, Alon N, Brunga L, Malkin D, Piazza S, Collavin L, Rosato A, Bicciato S, Tripodo C, Mantovani F, Del Sal G

Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome.

Nat Commun 2020; 3945. doi: 10.1038/s41467-020-17596-5

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Amodio V, Yaeger R, Arcella P, Cancelliere C, Lamba S, Lorenzato A, Arena S, Montone M, Mussolin B, Bian Y, Whaley A, Pinnelli M, Murciano-Goroff YR, Vakiani E, Valeri N, Liao WL, Bhalkikar A, Thyparambil S, Zhao HY, de Stanchina E, Marsoni S, Siena S, Bertotti A, Trusolino L, Li BT, Rosen N, Di Nicolantonio F, Bardelli A, Misale S

EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer.

Cancer Discov 2020; 1129-1139. doi: 10.1158/2159-8290.CD-20-0187

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Bisi S, Marchesi S, Rizvi A, Carra D, Beznoussenko GV, Ferrara I, Deflorian G, Mironov A, Bertalot G, Pisati F, Oldani A, Cattaneo A, Saberamoli G, Pece S, Viale G, Bachi A, Tripodo C, Scita G, Disanza A

IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules.

Nat Commun 2020; 3516. doi: 10.1038/s41467-020-17091-x

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Martano G, Leone M, D'Oro P, Matafora V, Cattaneo A, Masseroli M, Bachi A

SMfinder: Small Molecules Finder for Metabolomics and Lipidomics Analysis.

Anal Chem 2020; 8874-8882. doi: 10.1021/acs.analchem.0c00585

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Passaro M, Martinovic M, Bevilacqua V, Hershberg EA, Rossetti G, Beliveau BJ, Bonnal RJP, Pagani M

OligoMinerApp: a web-server application for the design of genome-scale oligonucleotide in situ hybridization probes through the flexible OligoMiner environment.

Nucleic Acids Res 2020; W332-W339. doi: 10.1093/nar/gkaa251

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Achar YJ, Foiani M

Ubiquitilated Fanconi ID complex embraces DNA.

Cell Res 2020; 554-555. doi: 10.1038/s41422-020-0345-2

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Panciera T, Citron A, Di Biagio D, Battilana G, Gandin A, Giulitti S, Forcato M, Bicciato S, Panzetta V, Fusco S, Azzolin L, Totaro A, Dei Tos AP, Fassan M, Vindigni V, Bassetto F, Rosato A, Brusatin G, Cordenonsi M, Piccolo S

Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties.

Nat Mater 2020; 797-806. doi: 10.1038/s41563-020-0615-x

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Caffa I, Spagnolo V, Vernieri C, Valdemarin F, Becherini P, Wei M, Brandhorst S, Zucal C, Driehuis E, Ferrando L, Piacente F, Tagliafico A, Cilli M, Mastracci L, Vellone VG, Piazza S, Cremonini AL, Gradaschi R, Mantero C, Passalacqua M, Ballestrero A, Zoppoli G, Cea M, Arrighi A, Odetti P, Monacelli F, Salvadori G, Cortellino S, Clevers H, De Braud F, Sukkar SG, Provenzani A, Longo VD, Nencioni A

Fasting-mimicking diet and hormone therapy induce breast cancer regression.

Nature 2020; 620-624. doi: 10.1038/s41586-020-2502-7

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Schiano Lomoriello I, Giangreco G, Iavarone C, Tordonato C, Caldieri G, Serio G, Confalonieri S, Freddi S, Bianchi F, Pirroni S, Bertalot G, Viale G, Disalvatore D, Tosoni D, Malabarba MG, Disanza A, Scita G, Pece S, Pilcher BK, Vecchi M, Sigismund S, Di Fiore PP

A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior.

Nat Commun 2020; 3020. doi: 10.1038/s41467-020-16836-y

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Coquel F, Silva MJ, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, Promonet A, Cribier A, Sarrazin A, Niedzwiedz W, Lopez B, Costanzo V, Krejci L, Chabes A, Benkirane M, Lin YL, Pasero P

[SAMHD1 acts at stalled replication forks to prevent interferon induction].

C R Biol 2020; 9-21. doi: 10.5802/crbiol.10

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Sartore-Bianchi A, Lonardi S, Aglietta M, Martino C, Ciardiello F, Marsoni S, Siena S

Central Nervous System as Possible Site of Relapse in ERBB2-Positive Metastatic Colorectal Cancer: Long-term Results of Treatment With Trastuzumab and Lapatinib.

JAMA Oncol 2020; 927-929. doi: 10.1001/jamaoncol.2020.0571

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Zattarin E, Vernieri C

Sarcopenia and monocyte-to-lymphocyte ratio as prognostic factors in early-stage breast cancer.

Ann Transl Med 2020; 737. doi: 10.21037/atm.2020.03.171

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Boulpicante M, Darrigrand R, Pierson A, Salgues V, Rouillon M, Gaudineau B, Khaled M, Cattaneo A, Bachi A, Cascio P, Apcher S

Tumors escape immunosurveillance by overexpressing the proteasome activator PSME3.

Oncoimmunology 2020; 1761205. doi: 10.1080/2162402X.2020.1761205

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D'Amico S, Krasnowska EK, Manni I, Toietta G, Baldari S, Piaggio G, Ranalli M, Gambacurta A, Vernieri C, Di Giacinto F, Bernassola F, de Braud F, Lucibello M

DHA Affects Microtubule Dynamics Through Reduction of Phospho-TCTP Levels and Enhances the Antiproliferative Effect of T-DM1 in Trastuzumab-Resistant HER2-Positive Breast Cancer Cell Lines.

Cells 2020; . doi: 10.3390/cells9051260

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Di Tano M, Raucci F, Vernieri C, Caffa I, Buono R, Fanti M, Brandhorst S, Curigliano G, Nencioni A, de Braud F, Longo VD

Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers.

Nat Commun 2020; 2332. doi: 10.1038/s41467-020-16243-3

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Agosti A, Marchesi S, Scita G, Ciarletta P

Modelling cancer cell budding in-vitro as a self-organised, non-equilibrium growth process.

J Theor Biol 2020; 110203. doi: 10.1016/j.jtbi.2020.110203

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Mirabile A, Rivoltini L, Daveri E, Vernieri C, Mele R, Porcu L, Lazzari C, Bulotta A, Viganò MG, Cascinu S, Gregorc V

Metabolism and Immune Modulation in Patients with Solid Tumors: Systematic Review of Preclinical and Clinical Evidence.

Cancers (Basel) 2020; . doi: 10.3390/cancers12051153

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Bianchi A, Mozzetta C, Pegoli G, Lucini F, Valsoni S, Rosti V, Petrini C, Cortesi A, Gregoretti F, Antonelli L, Oliva G, De Bardi M, Rizzi R, Bodega B, Pasini D, Ferrari F, Bearzi C, Lanzuolo C

Dysfunctional polycomb transcriptional repression contributes to lamin A/C-dependent muscular dystrophy.

J Clin Invest 2020; 2408-2421. doi: 10.1172/JCI128161

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Nastały P, Purushothaman D, Marchesi S, Poli A, Lendenmann T, Kidiyoor GR, Beznoussenko GV, Lavore S, Romano OM, Poulikakos D, Lagomarsino MC, Mironov AA, Ferrari A, Maiuri P

Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus.

Nat Commun 2020; 2122. doi: 10.1038/s41467-020-15910-9

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Vernieri C, Ganzinelli M, Rulli E, Farina G, Bettini AC, Bareggi C, Rosso L, Signorelli D, Galli G, Lo Russo G, Proto C, Moro M, Indraccolo S, Busico A, Sozzi G, Torri V, Marabese M, Massimo B, Garassino MC

LKB1 mutations are not associated with the efficacy of first-line and second-line chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC): a post hoc analysis of the TAILOR trial.

ESMO Open 2020; e000748. doi: 10.1136/esmoopen-2020-000748

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Vernieri C, Corti F, Nichetti F, Ligorio F, Manglaviti S, Zattarin E, Rea CG, Capri G, Bianchi GV, de Braud F

Everolimus versus alpelisib in advanced hormone receptor-positive HER2-negative breast cancer: targeting different nodes of the PI3K/AKT/mTORC1 pathway with different clinical implications.

Breast Cancer Res 2020; 33. doi: 10.1186/s13058-020-01271-0

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Jiménez-Martín A, Saugar I, Joseph CR, Mayer A, Lehmann CP, Szakal B, Branzei D, Tercero JA

The Mgs1/WRNIP1 ATPase is required to prevent a recombination salvage pathway at damaged replication forks.

Sci Adv 2020; eaaz3327. doi: 10.1126/sciadv.aaz3327

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Romano OM, Cosentino Lagomarsino M

Single rod-shaped cell fluctuations from stochastic surface and volume growth rates.

Phys Rev E 2020; 042403. doi: 10.1103/PhysRevE.101.042403

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Yousuf M, Iuliani I, Veetil RT, Seshasayee ASN, Sclavi B, Cosentino Lagomarsino M

Early fate of exogenous promoters in E. coli.

Nucleic Acids Res 2020; 2348-2356. doi: 10.1093/nar/gkz1196

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Arena S, Corti G, Durinikova E, Montone M, Reilly NM, Russo M, Lorenzato A, Arcella P, Lazzari L, Rospo G, Pagani M, Cancelliere C, Negrino C, Isella C, Bartolini A, Cassingena A, Amatu A, Mauri G, Sartore-Bianchi A, Mittica G, Medico E, Marsoni S, Linnebacher M, Abrignani S, Siena S, Di Nicolantonio F, Bardelli A

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin.

Clin Cancer Res 2020; 1372-1384. doi: 10.1158/1078-0432.CCR-19-2409

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Lorenzato A, Magrì A, Matafora V, Audrito V, Arcella P, Lazzari L, Montone M, Lamba S, Deaglio S, Siena S, Bertotti A, Trusolino L, Bachi A, Di Nicolantonio F, Bardelli A, Arena S

Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer.

Cancers (Basel) 2020; . doi: 10.3390/cancers12030685

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Atashpaz S, Samadi Shams S, Gonzalez JM, Sebestyén E, Arghavanifard N, Gnocchi A, Albers E, Minardi S, Faga G, Soffientini P, Allievi E, Cancila V, Bachi A, Fernández-Capetillo Ó, Tripodo C, Ferrari F, López-Contreras AJ, Costanzo V

ATR expands embryonic stem cell fate potential in response to replication stress.

Elife 2020; . doi: 10.7554/eLife.54756

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Falbo L, Raspelli E, Romeo F, Fiorani S, Pezzimenti F, Casagrande F, Costa I, Parazzoli D, Costanzo V

SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development.

Nat Commun 2020; 1345. doi: 10.1038/s41467-020-15180-5

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Vernieri C, Prisciandaro M, Nichetti F, Lobefaro R, Peverelli G, Ligorio F, Zattarin E, Cona MS, Sepe P, Corti F, Manglaviti S, Brambilla M, Re B, Belfiore A, Pruneri G, Celio L, Mariani G, Bianchi GV, Rivoltini L, Capri G, de Braud F

Oral Capecitabine-Vinorelbine is Associated with Longer Overall Survival When Compared to Single-Agent Capecitabine in Patients with Hormone Receptor-Positive Advanced Breast Cancer.

Cancers (Basel) 2020; . doi: 10.3390/cancers12030617

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Castagnoli L, De Santis F, Volpari T, Vernieri C, Tagliabue E, Di Nicola M, Pupa SM

Cancer Stem Cells: Devil or Savior-Looking behind the Scenes of Immunotherapy Failure.

Cells 2020; . doi: 10.3390/cells9030555

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Magrì A, Germano G, Lorenzato A, Lamba S, Chilà R, Montone M, Amodio V, Ceruti T, Sassi F, Arena S, Abrignani S, D'Incalci M, Zucchetti M, Di Nicolantonio F, Bardelli A

High-dose vitamin C enhances cancer immunotherapy.

Sci Transl Med 2020; . doi: 10.1126/scitranslmed.aay8707

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Ercilla A, Benada J, Amitash S, Zonderland G, Baldi G, Somyajit K, Ochs F, Costanzo V, Lukas J, Toledo L

Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication.

Cell Rep 2020; 2416-2429.e7. doi: 10.1016/j.celrep.2020.01.067

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Rossi F, Helbling-Leclerc A, Kawasumi R, Jegadesan NK, Xu X, Devulder P, Abe T, Takata M, Xu D, Rosselli F, Branzei D

SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability.

EMBO Rep 2020; e48222. doi: 10.15252/embr.201948222

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Barger SR, Gauthier NC, Krendel M

Squeezing in a Meal: Myosin Functions in Phagocytosis.

Trends Cell Biol 2020; 157-167. doi: 10.1016/j.tcb.2019.11.002

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Dhanda AS, Yu C, Lulic KT, Vogl AW, Rausch V, Yang D, Nichols BJ, Kim SH, Polo S, Hansen CG, Guttman JA

Listeria monocytogenes Exploits Host Caveolin for Cell-to-Cell Spreading.

mBio 2020; . doi: 10.1128/mBio.02857-19

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Achar YJ, Adhil M, Choudhary R, Gilbert N, Foiani M

Negative supercoil at gene boundaries modulates gene topology.

Nature 2020; 701-705. doi: 10.1038/s41586-020-1934-4

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Piccolo S

Linking cancer transcriptional addictions by CDK7 to YAP/TAZ.

Genes Dev 2020; 4-6. doi: 10.1101/gad.335562.119

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Capaci V, Mantovani F, Del Sal G

Amplifying Tumor-Stroma Communication: An Emerging Oncogenic Function of Mutant p53.

Front Oncol 2020; 614230. doi: 10.3389/fonc.2020.614230

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Pusceddu S, Vernieri C, Prinzi N, Torchio M, Coppa J, Antista M, Niger M, Milione M, Giacomelli L, Corti F, Prisciandaro M, Monteleone M, Colombo E, Di Bartolomeo M, de Braud F

The potential role of metformin in the treatment of patients with pancreatic neuroendocrine tumors: a review of preclinical to clinical evidence.

Ther Adv Gastroenterol 2020; 1756284820927271. doi: 10.1177/1756284820927271

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Tripodo C

Heterogeneity Fair: Commentary to Menter and Tzankov "Lymphomas and Their Microenvironment: A Multifaceted Relationship".

Pathobiology 2020; 155-158. doi: 10.1159/000507374

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Russo M, Crisafulli G, Sogari A, Reilly NM, Arena S, Lamba S, Bartolini A, Amodio V, Magrì A, Novara L, Sarotto I, Nagel ZD, Piett CG, Amatu A, Sartore-Bianchi A, Siena S, Bertotti A, Trusolino L, Corigliano M, Gherardi M, Lagomarsino MC, Di Nicolantonio F, Bardelli A

Adaptive mutability of colorectal cancers in response to targeted therapies.

Science 2019; 1473-1480. doi: 10.1126/science.aav4474

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De Simone G, Mazza EMC, Cassotta A, Davydov AN, Kuka M, Zanon V, De Paoli F, Scamardella E, Metsger M, Roberto A, Pilipow K, Colombo FS, Tenedini E, Tagliafico E, Gattinoni L, Mavilio D, Peano C, Price DA, Singh SP, Farber JM, Serra V, Cucca F, Ferrari F, Orrù V, Fiorillo E, Iannacone M, Chudakov DM, Sallusto F, Lugli E

CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential.

J Immunol 2019; 3179-3189. doi: 10.4049/jimmunol.1901072

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Bruhn C, Foiani M

A model of DNA damage response activation at stalled replication forks by SPRTN.

Nat Commun 2019; 5671. doi: 10.1038/s41467-019-13610-7

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Koschorke A, Faraci S, Giani D, Chiodoni C, Iorio E, Canese R, Colombo MP, Lamolinara A, Iezzi M, Ladomery M, Vernieri C, de Braud F, Di Nicola M, Tagliabue E, Castagnoli L, Pupa SM

Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment.

Cell Oncol (Dordr) 2019; 815-828. doi: 10.1007/s13402-019-00464-w

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Bhatt T, Bhosale A, Bajantri B, Mathapathi MS, Rizvi A, Scita G, Majumdar A, Jamora C

Sustained Secretion of the Antimicrobial Peptide S100A7 Is Dependent on the Downregulation of Caspase-8.

Cell Rep 2019; 2546-2555.e4. doi: 10.1016/j.celrep.2019.10.090

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Pal K, Forcato M, Jost D, Sexton T, Vaillant C, Salviato E, Mazza EMC, Lugli E, Cavalli G, Ferrari F

Global chromatin conformation differences in the Drosophila dosage compensated chromosome X.

Nat Commun 2019; 5355. doi: 10.1038/s41467-019-13350-8

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Psakhye I, Castellucci F, Branzei D

SUMO-Chain-Regulated Proteasomal Degradation Timing Exemplified in DNA Replication Initiation.

Mol Cell 2019; 632-645.e6. doi: 10.1016/j.molcel.2019.08.003

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Aguado J, Sola-Carvajal A, Cancila V, Revêchon G, Ong PF, Jones-Weinert CW, Wallén Arzt E, Lattanzi G, Dreesen O, Tripodo C, Rossiello F, Eriksson M, d'Adda di Fagagna F

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson-Gilford Progeria Syndrome.

Nat Commun 2019; 4990. doi: 10.1038/s41467-019-13018-3

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Hetmanski JHR, de Belly H, Busnelli I, Waring T, Nair RV, Sokleva V, Dobre O, Cameron A, Gauthier N, Lamaze C, Swift J, Del Campo A, Starborg T, Zech T, Goetz JG, Paluch EK, Schwartz JM, Caswell PT

Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration.

Dev Cell 2019; 460-475.e10. doi: 10.1016/j.devcel.2019.09.006

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Nigro EA, Distefano G, Chiaravalli M, Matafora V, Castelli M, Pesenti Gritti A, Bachi A, Boletta A

Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness.

Sci Rep 2019; 16640. doi: 10.1038/s41598-019-53061-0

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