Il nostro contributo

L’impatto scientifico misura l’influenza e la rilevanza delle scoperte e delle pubblicazioni di un istituto di ricerca. Per IFOM, l’impatto scientifico non si limita solo alla quantità di pubblicazioni, ma si estende alla qualità delle riviste su cui vengono pubblicati i nostri studi, alla visibilità dei nostri risultati e alla capacità di trasformare queste scoperte in avanzamenti concreti nella lotta contro il cancro.

Cortellino S, Raveane A, Chiodoni C, Delfanti G, Pisati F, Spagnolo V, Visco E, Fragale G, Ferrante F, Magni S, Iannelli F, Zanardi F, Casorati G, Bertolini F, Dellabona P, Colombo MP, Tripodo C, Longo VD

Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects.

Cell Rep 2022; 111256. doi: 10.1016/j.celrep.2022.111256

Mauri G, Vitiello PP, Sogari A, Crisafulli G, Sartore-Bianchi A, Marsoni S, Siena S, Bardelli A

Liquid biopsies to monitor and direct cancer treatment in colorectal cancer.

Br J Cancer 2022; 394-407. doi: 10.1038/s41416-022-01769-8

Sartore-Bianchi A, Pietrantonio F, Lonardi S, Mussolin B, Rua F, Crisafulli G, Bartolini A, Fenocchio E, Amatu A, Manca P, Bergamo F, Tosi F, Mauri G, Ambrosini M, Daniel F, Torri V, Vanzulli A, Regge D, Cappello G, Marchiò C, Berrino E, Sapino A, Marsoni S, Siena S, Bardelli A

Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial.

Nat Med 2022; 1612-1618. doi: 10.1038/s41591-022-01886-0

Wai CMM, Chen S, Phyu T, Fan S, Leong SM, Zheng W, Low LCY, Choo SN, Lee CK, Chung TH, Ban KHK, Ghosh S, Lie S, Kato S, Nakamura S, Takahashi E, Ko YH, Khoury JD, Chuang SS, Au-Yeung RKH, Tan SY, Lim ST, Ong CK, Ho YH, Poon LM, De Mel S, Jeyasekharan AD, Chng WJ, Otto F, Quintanilla-Martinez L, Zanardi F, Iannelli F, Tripodo C, Pitt JJ, Ng SB

Immune pathway upregulation and lower genomic instability distinguish EBV-positive nodal T/NK-cell lymphoma from ENKTL and PTCL-NOS.

Haematologica 2022; 1864-1879. doi: 10.3324/haematol.2021.280003

L'Imperio V, Morello G, Vegliante MC, Cancila V, Bertolazzi G, Mazzara S, Belmonte B, Mangogna A, Balzarini P, Corral L, Lopez G, Di Napoli A, Facchetti F, Pagni F, Tripodo C

Spatial transcriptome of a germinal center plasmablastic burst hints at MYD88/CD79B mutants-enriched diffuse large B-cell lymphomas.

Eur J Immunol 2022; 1350-1361. doi: 10.1002/eji.202149746

Donzelli S, Cioce M, Sacconi A, Zanconato F, Daralioti T, Goeman F, Orlandi G, Di Martino S, Fazio VM, Alessandrini G, Telera S, Carosi M, Ciliberto G, Botti C, Strano S, Piccolo S, Blandino G

A PIK3CA-mutant breast cancer metastatic patient-derived organoid approach to evaluate alpelisib treatment for multiple secondary lesions.

Mol Cancer 2022; 152. doi: 10.1186/s12943-022-01617-6

Russo M, Pompei S, Sogari A, Corigliano M, Crisafulli G, Puliafito A, Lamba S, Erriquez J, Bertotti A, Gherardi M, Di Nicolantonio F, Bardelli A, Cosentino Lagomarsino M

A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells.

Nat Genet 2022; 976-984. doi: 10.1038/s41588-022-01105-z

Sladitschek-Martens HL, Guarnieri A, Brumana G, Zanconato F, Battilana G, Xiccato RL, Panciera T, Forcato M, Bicciato S, Guzzardo V, Fassan M, Ulliana L, Gandin A, Tripodo C, Foiani M, Brusatin G, Cordenonsi M, Piccolo S

YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING.

Nature 2022; 790-798. doi: 10.1038/s41586-022-04924-6

Gamba R, Mazzucco G, Wilhelm T, Velikovsky L, Salinas-Luypaert C, Chardon F, Picotto J, Bohec M, Baulande S, Doksani Y, Fachinetti D

Enrichment of centromeric DNA from human cells.

PLoS Genet 2022; e1010306. doi: 10.1371/journal.pgen.1010306

Panebianco C, Villani A, Pisati F, Orsenigo F, Ulaszewska M, Latiano TP, Potenza A, Andolfo A, Terracciano F, Tripodo C, Perri F, Pazienza V

Butyrate, a postbiotic of intestinal bacteria, affects pancreatic cancer and gemcitabine response in in vitro and in vivo models.

Biomed Pharmacother 2022; 113163. doi: 10.1016/j.biopha.2022.113163

Ong YT, Andrade J, Armbruster M, Shi C, Castro M, Costa ASH, Sugino T, Eelen G, Zimmermann B, Wilhelm K, Lim J, Watanabe S, Guenther S, Schneider A, Zanconato F, Kaulich M, Pan D, Braun T, Gerhardt H, Efeyan A, Carmeliet P, Piccolo S, Grosso AR, Potente M

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth.

Nat Metab 2022; 672-682. doi: 10.1038/s42255-022-00584-y

Lorenzoni M, De Felice D, Beccaceci G, Di Donato G, Foletto V, Genovesi S, Bertossi A, Cambuli F, Lorenzin F, Savino A, Avalle L, Cimadamore A, Montironi R, Weber V, Carbone FG, Barbareschi M, Demichelis F, Romanel A, Poli V, Del Sal G, Julio MK, Gaspari M, Alaimo A, Lunardi A

ETS-related gene (ERG) undermines genome stability in mouse prostate progenitors via Gsk3β dependent Nkx3.1 degradation.

Cancer Lett 2022; 215612. doi: 10.1016/j.canlet.2022.215612

Purushothaman D, Bianchi LF, Penkov D, Poli A, Li Q, Vermezovic J, Pramotton FM, Choudhary R, Pennacchio FA, Sommariva E, Foiani M, Gauthier N, Maiuri P, Blasi F

The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction.

Commun Biol 2022; 456. doi: 10.1038/s42003-022-03406-9

Calabrese L, Grilli J, Osella M, Kempes CP, Lagomarsino MC, Ciandrini L

Protein degradation sets the fraction of active ribosomes at vanishing growth.

PLoS Comput Biol 2022; e1010059. doi: 10.1371/journal.pcbi.1010059

Buemi V, Schillaci O, Santorsola M, Bonazza D, Broccia PV, Zappone A, Bottin C, Dell'Omo G, Kengne S, Cacchione S, Raffa GD, Piazza S, di Fagagna FD, Benetti R, Cortale M, Zanconati F, Del Sal G, Schoeftner S

TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance.

Nat Commun 2022; 2302. doi: 10.1038/s41467-022-29907-z

Green BJ, Marazzini M, Hershey B, Fardin A, Li Q, Wang Z, Giangreco G, Pisati F, Marchesi S, Disanza A, Frittoli E, Martini E, Magni S, Beznoussenko GV, Vernieri C, Lobefaro R, Parazzoli D, Maiuri P, Havas K, Labib M, Sigismund S, Fiore PPD, Gunby RH, Kelley SO, Scita G

PillarX: A Microfluidic Device to Profile Circulating Tumor Cell Clusters Based on Geometry, Deformability, and Epithelial State.

Small 2022; e2106097. doi: 10.1002/smll.202106097

Velletri T, Villa CE, Cilli D, Barzaghi B, Lo Riso P, Lupia M, Luongo R, López-Tobón A, De Simone M, Bonnal RJP, Marelli L, Piccolo S, Colombo N, Pagani M, Cavallaro U, Minucci S, Testa G

Single cell-derived spheroids capture the self-renewing subpopulations of metastatic ovarian cancer.

Cell Death Differ 2022; 614-626. doi: 10.1038/s41418-021-00878-w

Büke F, Grilli J, Cosentino Lagomarsino M, Bokinsky G, Tans SJ

ppGpp is a bacterial cell size regulator.

Curr Biol 2022; 870-877.e5. doi: 10.1016/j.cub.2021.12.033

Amatu A, Mauri G, Tosi F, Bencardino K, Bonazzina E, Gori V, Ruggieri L, Arena S, Bardelli A, Marsoni S, Siena S, Sartore-Bianchi A

Efficacy of Retreatment with Oxaliplatin-Based Regimens in Metastatic Colorectal Cancer Patients: The RETROX-CRC Retrospective Study.

Cancers (Basel) 2022; . doi: 10.3390/cancers14051197

Sepe S, Rossiello F, Cancila V, Iannelli F, Matti V, Cicio G, Cabrini M, Marinelli E, Alabi BR, di Lillo A, Di Napoli A, Shay JW, Tripodo C, d'Adda di Fagagna F

DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging.

EMBO Rep 2022; e53658. doi: 10.15252/embr.202153658

Magistrati E, Maestrini G, Niño CA, Lince-Faria M, Beznoussenko G, Mironov A, Maspero E, Bettencourt-Dias M, Polo S

Myosin VI regulates ciliogenesis by promoting the turnover of the centrosomal/satellite protein OFD1.

EMBO Rep 2022; e54160. doi: 10.15252/embr.202154160

Rossiello F, Jurk D, Passos JF, d'Adda di Fagagna F

Telomere dysfunction in ageing and age-related diseases.

Nat Cell Biol 2022; 135-147. doi: 10.1038/s41556-022-00842-x

Alexa A, Sok P, Gross F, Albert K, Kobori E, Póti ÁL, Gógl G, Bento I, Kuang E, Taylor SS, Zhu F, Ciliberto A, Reményi A

A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.

Nat Commun 2022; 472. doi: 10.1038/s41467-022-28109-x

Jevtic Z, Matafora V, Casagrande F, Santoro F, Minucci S, Garre' M, Rasouli M, Heidenreich O, Musco G, Schwaller J, Bachi A

SMARCA5 interacts with NUP98-NSD1 oncofusion protein and sustains hematopoietic cells transformation.

J Exp Clin Cancer Res 2022; 34. doi: 10.1186/s13046-022-02248-x

Chen D, Gervai JZ, Póti Á, Németh E, Szeltner Z, Szikriszt B, Gyüre Z, Zámborszky J, Ceccon M, d'Adda di Fagagna F, Szallasi Z, Richardson AL, Szüts D

BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1.

Nat Commun 2022; 226. doi: 10.1038/s41467-021-27872-7

Giannini V, Pusceddu L, Defeudis A, Nicoletti G, Cappello G, Mazzetti S, Sartore-Bianchi A, Siena S, Vanzulli A, Rizzetto F, Fenocchio E, Lazzari L, Bardelli A, Marsoni S, Regge D

Delta-Radiomics Predicts Response to First-Line Oxaliplatin-Based Chemotherapy in Colorectal Cancer Patients with Liver Metastases.

Cancers (Basel) 2022; . doi: 10.3390/cancers14010241

Vacca D, Fiannaca A, Tramuto F, Cancila V, La Paglia L, Mazzucco W, Gulino A, La Rosa M, Maida CM, Morello G, Belmonte B, Casuccio A, Maugeri R, Iacopino G, Balistreri CR, Vitale F, Tripodo C, Urso A

Direct RNA Nanopore Sequencing of SARS-CoV-2 Extracted from Critical Material from Swabs.

Life (Basel) 2022; . doi: 10.3390/life12010069

Vernieri C, Fucà G, Ligorio F, Huber V, Vingiani A, Iannelli F, Raimondi A, Rinchai D, Frigè G, Belfiore A, Lalli L, Chiodoni C, Cancila V, Zanardi F, Ajazi A, Cortellino S, Vallacchi V, Squarcina P, Cova A, Pesce S, Frati P, Mall R, Corsetto PA, Rizzo AM, Ferraris C, Folli S, Garassino MC, Capri G, Bianchi G, Colombo MP, Minucci S, Foiani M, Longo VD, Apolone G, Torri V, Pruneri G, Bedognetti D, Rivoltini L, de Braud F

Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer.

Cancer Discov 2022; 90-107. doi: 10.1158/2159-8290.CD-21-0030

Simula L, Antonucci Y, Scarpelli G, Cancila V, Colamatteo A, Manni S, De Angelis B, Quintarelli C, Procaccini C, Matarese G, Tripodo C, Campello S

PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism.

Mol Oncol 2022; 188-205. doi: 10.1002/1878-0261.13103

Stadiotti I, Santoro R, Scopece A, Pirola S, Guarino A, Polvani G, Maione AS, Ascione F, Li Q, Delia D, Foiani M, Pompilio G, Sommariva E

Pressure Overload Activates DNA-Damage Response in Cardiac Stromal Cells: A Novel Mechanism Behind Heart Failure With Preserved Ejection Fraction?

Front Cardiovasc Med 2022; 878268. doi: 10.3389/fcvm.2022.878268

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