Il nostro contributo

L’impatto scientifico misura l’influenza e la rilevanza delle scoperte e delle pubblicazioni di un istituto di ricerca. Per IFOM, l’impatto scientifico non si limita solo alla quantità di pubblicazioni, ma si estende alla qualità delle riviste su cui vengono pubblicati i nostri studi, alla visibilità dei nostri risultati e alla capacità di trasformare queste scoperte in avanzamenti concreti nella lotta contro il cancro.

Nichetti F, Brambilla M, Duca M, Piccolo A, Miliziano D, Cavalli C, Marra F, Ambrosini P, Zanella C, Vernieri C, Lorenzini D, Colombo E, Damian S, Baili P, Proto C, Busico A, Conca E, Capone I, Manoukian S, Tamborini E, Perrone F, Niger M, Vingiani A, Agnelli L, de Braud F, Pruneri G

Real-World Outcomes of Molecular Tumor Board Treatment Recommendations.

JCO Precis Oncol 2025; e2400387. doi: 10.1200/PO-24-00387

Maspero E, Cappa A, Weber J, Trifirò P, Amici R, Bruno A, Fagà G, Cecatiello V, Fattori R, Leuzzi B, Taibi V, Meroni G, Pasi M, Romussi A, Sartori L, Villa M, Vultaggio S, Cirò M, Soffientini P, Lombardo L, Dahe S, Bachi A, Varasi M, Rossi M, Pasqualato S, Mercurio C, Polo S

Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4.

Commun Chem 2025; 164. doi: 10.1038/s42004-025-01557-4

Grassi E, Vurchio V, Cresswell GD, Catalano I, Lupo B, Sassi F, Galimi F, Borgato S, Ferri M, Viviani M, Pompei S, Urgese G, Chen B, Zanella ER, Cottino F, Russo M, Mauri G, Pietrantonio F, Zampino MG, Lazzari L, Marsoni S, Bardelli A, Lagomarsino MC, Sottoriva A, Trusolino L, Bertotti A

Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer.

Sci Transl Med 2025; eado1641. doi: 10.1126/scitranslmed.ado1641

Alcon C, Kovatcheva M, Morales-Sánchez P, López-Polo V, Torres T, Puig S, Lu A, Samitier J, Enrich C, Serrano M, Montero J

HRK downregulation and augmented BCL-xL binding to BAK confer apoptotic protection to therapy-induced senescent melanoma cells.

Cell Death Differ 2025; 646-656. doi: 10.1038/s41418-024-01417-z

Petti E, Di Vito S, Dinami R, Porru M, Marchesi S, Lohuis J, Zizza P, Iachettini S, Salvati E, D'Angelo C, Rizzo A, Maresca C, Ascione F, Di Benedetto A, Buglioni S, Sacconi A, Ostano P, Li Q, Stoppacciaro A, Leonetti C, van Rheenen J, Maiuri P, Scita G, Biroccio A

TRF2 interaction with nuclear envelope is required for cell polarization and metastasis in triple negative breast cancer.

Cell Death Dis 2025; 224. doi: 10.1038/s41419-025-07415-4

Droghetti R, Fuchs P, Iuliani I, Firmano V, Tallarico G, Calabrese L, Grilli J, Sclavi B, Ciandrini L, Cosentino Lagomarsino M

Incoherent feedback from coupled amino acids and ribosome pools generates damped oscillations in growing E. coli.

Nat Commun 2025; 3063. doi: 10.1038/s41467-025-57789-4

Peña-Gómez MJ, Rodríguez-Martín Y, Del Rio Oliva M, Wijesekara Hanthi Y, Berrada S, Freire R, Masson JY, Reyes JC, Costanzo V, Rosado IV

HMCES corrupts replication fork stability during base excision repair in homologous recombination-deficient cells.

Sci Adv 2025; eads3227. doi: 10.1126/sciadv.ads3227

Romero-Zamora D, Rogers S, Low RRJ, Page SG, Lane BJE, Kosaka S, Robinson AB, French L, Lamm N, Ishikawa F, Hayashi MT, Cesare AJ

A CPC-shelterin-BTR axis regulates mitotic telomere deprotection.

Nat Commun 2025; 2277. doi: 10.1038/s41467-025-57456-8

Bertolazzi G, Cancila V, Vacca D, Belmonte B, Lecis D, Moghaddam PS, Di Napoli A, Colombo MP, Pruneri G, Del Sal G, Scita G, Fassan M, Vecchione A, Bicciato S, Tripodo C

Extraction of a stromal metastatic gene signature in breast cancer via spatial profiling.

J Exp Clin Cancer Res 2025; 89. doi: 10.1186/s13046-025-03353-3

Marchesi S, Guidolin C, Massey AE, Lemahieu G, Lavagnino Z, Beznoussenko GV, Mironov AA, Green B, Allievi E, Martini E, Magni S, Ghisleni A, Lomazzi C, Benvenuto AF, Schertel A, Parazzoli D, Maiuri P, Sigismund S, Gauthier N, Cavalcanti-Adam AE, Cartagena-Rivera AX, Giavazzi F, Scita G, Disanza A

Biophysical and Molecular mechanisms that control active wetting and tissue fluidification in epithelial tissues.

Res Sq 2025; . doi: 10.21203/rs.3.rs-6008502/v1

Stier AB, Bonaiuti P, Juhász J, Gross F, Ciliberto A

lncreased risk of slippage upon disengagement of the mitotic checkpoint.

PLoS Comput Biol 2025; e1012879. doi: 10.1371/journal.pcbi.1012879

Bonilla-Quintana M, Ghisleni A, Gauthier NC, Rangamani P

Dynamic mechanisms for membrane skeleton transitions.

J Cell Sci 2025; . doi: 10.1242/jcs.263473

Di Giovannantonio M, Hartley F, Elshenawy B, Barberis A, Hudson D, Shafique HS, Allott VES, Harris DA, Lord SR, Haider S, Harris AL, Buffa FM, Harris BHL

Defining hypoxia in cancer: A landmark evaluation of hypoxia gene expression signatures.

Cell Genom 2025; 100764. doi: 10.1016/j.xgen.2025.100764

Tamburri S, Zucchelli C, Matafora V, Zapparoli E, Jevtic Z, Farris F, Iannelli F, Musco G, Bachi A

SP140 represses specific loci by recruiting polycomb repressive complex 2 and NuRD complex.

Nucleic Acids Res 2025; . doi: 10.1093/nar/gkae1215

Ligorio F, Vingiani A, Torelli T, Sposetti C, Drufuca L, Iannelli F, Zanenga L, Depretto C, Folli S, Scaperrotta G, Capri G, Bianchi GV, Ferraris C, Martelli G, Maugeri I, Provenzano L, Nichetti F, Agnelli L, Lobefaro R, Fucà G, Fotia G, Mariani L, Morelli D, Ladisa V, De Santis MC, Lozza L, Trecate G, Belfiore A, Brich S, Bertolotti A, Lorenzini D, Ficchì A, Martinetti A, Sottotetti E, Arata A, Corsetto P, Sorrentino L, Rediti M, Salvadori G, Minucci S, Foiani M, Apolone G, Pagani M, Pruneri G, de Braud F, Vernieri C

Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer patients.

Cell Metab 2025; 330-344.e7. doi: 10.1016/j.cmet.2024.11.004

Berton Giachetti PPM, Morganti S, Gandini S, Giudici F, Marra A, Nicolò E, Zattarin E, Corti C, Boldrini L, Verrazzo A, Sposetti C, Razeti MG, Carnevale Schianca A, Scafetta R, Taurelli Salimbeni B, Esposito A, Zagami P, Trapani D, Malagutti B, Caputo R, Vernieri C, Munzone E, Scagnoli S, Botticelli A, Lambertini M, Giuliano M, De Laurentiis M, Viale G, Bianchini G, Curigliano G, De Angelis C, Criscitiello C

Survival Following CDK4/6 Inhibitor Therapy for Hormone Receptor-Positive, ERBB2-Negative Metastatic Breast Cancer.

JAMA Netw Open 2025; e2461067. doi: 10.1001/jamanetworkopen.2024.61067

Castagnoli L, Franceschini A, Cancila V, Dugo M, Bigliardi M, Chiodoni C, Toneguzzo P, Regondi V, Corsetto PA, Pietrantonio F, Mazzucchelli S, Corsi F, Belfiore A, Vingiani A, Pruneri G, Ligorio F, Colombo MP, Tagliabue E, Tripodo C, Vernieri C, Triulzi T, Pupa SM

CD36 enrichment in HER2-positive mesenchymal stem cells drives therapy refractoriness in breast cancer.

J Exp Clin Cancer Res 2025; 19. doi: 10.1186/s13046-025-03276-z

Introini V, Porcella G, Kidiyoor GR, Cicuta P, Cosentino Lagomarsino M

Quantifying Nuclear Shape Fluctuations During Early Mitosis.

Methods Mol Biol 2025; 151-158. doi: 10.1007/978-1-0716-4714-1_10

Azzollini J, Capone I, Duca M, Vingiani A, Piccolo A, Agnelli L, Tamborini E, Perrone F, Peissel B, Lorenzini D, Damian S, Vernieri C, Bianchi GV, Mantiero M, Ducceschi M, Polignano M, Niger M, Nichetti F, Proto C, Brambilla M, Colombo E, Stellato M, Conca E, Busico A, Manoukian S

Is tumour sequencing effective for the identification of germline BRCA1/2 pathogenic variant carriers?

Tumori 2024; 3008916241280127. doi: 10.1177/03008916241280127

Protasoni M, López-Polo V, Stephan-Otto Attolini C, Brandariz J, Herranz N, Mateo J, Ruiz S, Fernandez-Capetillo O, Kovatcheva M, Serrano M

Cyclophilin D plays a critical role in the survival of senescent cells.

EMBO J 2024; 5972-6000. doi: 10.1038/s44318-024-00259-2

Massa D, Vernieri C, Nicolè L, Criscitiello C, Boissière-Michot F, Guiu S, Bobrie A, Griguolo G, Miglietta F, Vingiani A, Lobefaro R, Taurelli Salimbeni B, Pinato C, Schiavi F, Brich S, Pescia C, Fusco N, Pruneri G, Fassan M, Curigliano G, Guarneri V, Jacot W, Dieci MV

Immune and gene-expression profiling in estrogen receptor low and negative early breast cancer.

J Natl Cancer Inst 2024; 1914-1927. doi: 10.1093/jnci/djae178

Lucioni M, Morello G, Cristinelli C, Fraticelli S, Neri G, Travaglino E, Minetto M, Antoci F, Libretti P, Gambacorta M, Arcaini L, Tripodo C, Paulli M

Interleukin-6 transcripts up-regulation in lymph nodes from unicentric and multicentric Castleman disease.

EJHaem 2024; 1182-1189. doi: 10.1002/jha2.1034

Macagno M, Pessei V, Congiusta N, Lazzari L, Bellomo SE, Idrees F, Cavaliere A, Pietrantonio F, Raimondi A, Gusmaroli E, Zampino MG, Gervaso L, Ciardiello D, Mondello G, Santoro A, Personeni N, Bonoldi E, Aquilano MC, Valtorta E, Siena S, Sartore-Bianchi A, Amatu A, Bonazzina EF, Bencardino KB, Serini G, Marsoni S, Barault L, Di Nicolantonio F, Maione F

A Comparative Study of Methyl-BEAMing and Droplet Digital PCR for MGMT Gene Promoter Hypermethylation Detection.

Diagnostics (Basel) 2024; . doi: 10.3390/diagnostics14222467

Pham VC, Rödel CJ, Valentino M, Malinverno M, Paolini A, Münch J, Pasquier C, Onyeogaziri FC, Lazovic B, Girard R, Koskimäki J, Hußmann M, Keith B, Jachimowicz D, Kohl F, Hagelkruys A, Penninger JM, Schulte-Merker S, Awad IA, Hicks R, Magnusson PU, Faurobert E, Pagani M, Abdelilah-Seyfried S

Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations.

EMBO Mol Med 2024; 2827-2855. doi: 10.1038/s44321-024-00152-9

Pessei V, Macagno M, Mariella E, Congiusta N, Battaglieri V, Battuello P, Viviani M, Gionfriddo G, Lamba S, Lorenzato A, Oddo D, Idrees F, Cavaliere A, Bartolini A, Guarrera S, Linnebacher M, Monteonofrio L, Cardone L, Milella M, Bertotti A, Soddu S, Grassi E, Crisafulli G, Bardelli A, Barault L, Di Nicolantonio F

DNA demethylation triggers cell free DNA release in colorectal cancer cells.

Genome Med 2024; 118. doi: 10.1186/s13073-024-01386-5

Russo M, Chen M, Mariella E, Peng H, Rehman SK, Sancho E, Sogari A, Toh TS, Balaban NQ, Batlle E, Bernards R, Garnett MJ, Hangauer M, Leucci E, Marine JC, O'Brien CA, Oren Y, Patton EE, Robert C, Rosenberg SM, Shen S, Bardelli A

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities.

Nat Rev Cancer 2024; 694-717. doi: 10.1038/s41568-024-00737-z

Popęda M, Kowalski K, Wenta T, Beznoussenko GV, Rychłowski M, Mironov A, Lavagnino Z, Barozzi S, Richert J, Bertolio R, Myszczyński K, Szade J, Bieńkowski M, Miszewski K, Matuszewski M, Żaczek AJ, Braga L, Del Sal G, Bednarz-Knoll N, Maiuri P, Nastały P

Emerin mislocalization during chromatin bridge resolution can drive prostate cancer cell invasiveness in a collagen-rich microenvironment.

Exp Mol Med 2024; 2016-2032. doi: 10.1038/s12276-024-01308-w

Martin S, Scorzoni S, Cordone S, Mazzagatti A, Beznoussenko GV, Gunn AL, Di Bona M, Eliezer Y, Leor G, Ben-Yishay T, Loffreda A, Cancila V, Rainone MC, Ippolito MR, Martis V, Bedin F, Garrè M, Vaites LP, Vasapolli P, Polo S, Parazzoli D, Tripodo C, Mironov AA, Cuomo A, Ben-David U, Bakhoum SF, Hatch EM, Ly P, Santaguida S

A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements.

Science 2024; eadj7446. doi: 10.1126/science.adj7446

López-Polo V, Maus M, Zacharioudakis E, Lafarga M, Attolini CS, Marques FDM, Kovatcheva M, Gavathiotis E, Serrano M

Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells.

Nat Commun 2024; 7378. doi: 10.1038/s41467-024-51363-0

Valentino M, Malinverno M, Maderna C, Pham VC, Rödel CJ, Zanardi F, Arce M, Drufuca L, Rossetti G, Magnusson PU, Lampugnani MG, Dejana E, Abdelilah-Seyfried S, Pagani M

BMI1 Inhibition Improves Lesion Burden in Cerebral Cavernous Malformations.

Circulation 2024; 738-741. doi: 10.1161/CIRCULATIONAHA.123.067438

Siciliano MC, Bertolazzi G, Morello G, Tornambè S, Del Corvo M, Granai M, Sapienza MR, Leahy CI, Fennell E, Belmonte B, Arcuri F, Vannucchi M, Mancini V, Guazzo R, Boccacci R, Onyango N, Nyagol J, Santi R, Di Stefano G, Ferrara D, Bellan C, Marafioti T, Ott G, Siebert R, Quintanilla-Fend L, Fend F, Murray P, Tripodo C, Pileri S, Lazzi S, Leoncini L

Tumor microenvironment of Burkitt lymphoma: different immune signatures with different clinical behavior.

Blood Adv 2024; 4330-4343. doi: 10.1182/bloodadvances.2023011506

Kaivola J, Punovuori K, Chastney MR, Miroshnikova YA, Abdo H, Bertillot F, Krautgasser F, Franco JD, Conway JRW, Follain G, Hagström J, Mäkitie A, Irjala H, Ventelä S, Hamidi H, Scita G, Cerbino R, Wickström SA, Ivaska J

Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer.

bioRxiv 2024; . doi: 10.1101/2024.08.22.609159

Hanthi YW, Ramirez-Otero MA, Appleby R, De Antoni A, Joudeh L, Sannino V, Waked S, Ardizzoia A, Barra V, Fachinetti D, Pellegrini L, Costanzo V

RAD51 protects abasic sites to prevent replication fork breakage.

Mol Cell 2024; 3026-3043.e11. doi: 10.1016/j.molcel.2024.07.004

Ogrodnik M, Carlos Acosta J, Adams PD, d'Adda di Fagagna F, Baker DJ, Bishop CL, Chandra T, Collado M, Gil J, Gorgoulis V, Gruber F, Hara E, Jansen-Dürr P, Jurk D, Khosla S, Kirkland JL, Krizhanovsky V, Minamino T, Niedernhofer LJ, Passos JF, Ring NAR, Redl H, Robbins PD, Rodier F, Scharffetter-Kochanek K, Sedivy JM, Sikora E, Witwer K, von Zglinicki T, Yun MH, Grillari J, Demaria M

Guidelines for minimal information on cellular senescence experimentation in vivo.

Cell 2024; 4150-4175. doi: 10.1016/j.cell.2024.05.059

Koppold DA, Breinlinger C, Hanslian E, Kessler C, Cramer H, Khokhar AR, Peterson CM, Tinsley G, Vernieri C, Bloomer RJ, Boschmann M, Bragazzi NL, Brandhorst S, Gabel K, Goldhamer AC, Grajower MM, Harvie M, Heilbronn L, Horne BD, Karras SN, Langhorst J, Lischka E, Madeo F, Mitchell SJ, Papagiannopoulos-Vatopaidinos IE, Papagiannopoulou M, Pijl H, Ravussin E, Ritzmann-Widderich M, Varady K, Adamidou L, Chihaoui M, de Cabo R, Hassanein M, Lessan N, Longo V, Manoogian ENC, Mattson MP, Muhlestein JB, Panda S, Papadopoulou SK, Rodopaios NE, Stange R, Michalsen A

International consensus on fasting terminology.

Cell Metab 2024; 1779-1794.e4. doi: 10.1016/j.cmet.2024.06.013

Roa P, Foglizzo V, Harada G, Repetto M, Kulick A, de Stanchina E, de Marchena M, Auwardt S, Sayed Ahmed S, Bremer NV, Yang SR, Feng Y, Zhou C, Kong N, Liang R, Xu H, Zhang B, Bardelli A, Toska E, Ventura A, Drilon A, Cocco E

Zurletrectinib is a next-generation TRK inhibitor with strong intracranial activity against NTRK fusion-positive tumours with on-target resistance to first-generation agents.

Br J Cancer 2024; 601-610. doi: 10.1038/s41416-024-02760-1

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