Maspero E, Cappa A, Weber J, Trifirò P, Amici R, Bruno A, Fagà G, Cecatiello V, Fattori R, Leuzzi B, Taibi V, Meroni G, Pasi M, Romussi A, Sartori L, Villa M, Vultaggio S, Cirò M, Soffientini P, Lombardo L, Dahe S, Bachi A, Varasi M, Rossi M, Pasqualato S, Mercurio C, Polo S

Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4.

Commun Chem 2025; 164. doi: 10.1038/s42004-025-01557-4

Lauriola A, Enriqué Steinberg JH, Sarubo M, Maspero E, Rossi FA, Mouri Y, Pedretti M, Hajisadeghian M, Taibi V, Vettori A, Vitulo N, Assfalg M, D'Onofrio M, Rossi M, Yasue A, Astegno A, Polo S, Santi S, Kudo Y, Guardavaccaro D

The E3 ligase RNF32 controls the IκB kinase complex and NF-κB signaling in intestinal stem cells.

Mol Cell 2025; 4254-4267.e9. doi: 10.1016/j.molcel.2025.10.005

Casola S, Ungaro P, Pedone PV, Lazzaro D, Fattori E, Ciliberto G, Zarrilli R, Bruni CB, Riccio A

Loss of heterozygosity of imprinted genes in SV40 t/T antigen-induced hepatocellular carcinomas.

Oncogene 1995; 711-21.

Casola S, Pedone PV, Cavazzana AO, Basso G, Luksch R, d'Amore ES, Carli M, Bruni CB, Riccio A

Expression and parental imprinting of the H19 gene in human rhabdomyosarcoma.

Oncogene 1997; 1503-10. doi: 10.1038/sj.onc.1200956

Casola S, Otipoby KL, Alimzhanov M, Humme S, Uyttersprot N, Kutok JL, Carroll MC, Rajewsky K

B cell receptor signal strength determines B cell fate.

Nat Immunol 2004; 317-27. doi: 10.1038/ni1036

Novobrantseva TI, Majeau GR, Amatucci A, Kogan S, Brenner I, Casola S, Shlomchik MJ, Koteliansky V, Hochman PS, Ibraghimov A

Attenuated liver fibrosis in the absence of B cells.

J Clin Invest 2005; 3072-82. doi: 10.1172/JCI24798

Casola S, Cattoretti G, Uyttersprot N, Koralov SB, Seagal J, Hao Z, Waisman A, Egert A, Ghitza D, Rajewsky K

Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting.

Proc Natl Acad Sci U S A 2006; 7396-401. doi: 10.1073/pnas.0602353103

Klein U, Casola S, Cattoretti G, Shen Q, Lia M, Mo T, Ludwig T, Rajewsky K, Dalla-Favera R

Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.

Nat Immunol 2006; 773-82. doi: 10.1038/ni1357

Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K

Regulation of the germinal center response by microRNA-155.

Science 2007; 604-8. doi: 10.1126/science.1141229

Hömig-Hölzel C, Hojer C, Rastelli J, Casola S, Strobl LJ, Müller W, Quintanilla-Martinez L, Gewies A, Ruland J, Rajewsky K, Zimber-Strobl U

Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis.

J Exp Med 2008; 1317-29. doi: 10.1084/jem.20080238

Hao Z, Duncan GS, Seagal J, Su YW, Hong C, Haight J, Chen NJ, Elia A, Wakeham A, Li WY, Liepa J, Wood GA, Casola S, Rajewsky K, Mak TW

Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis.

Immunity 2008; 615-27. doi: 10.1016/j.immuni.2008.07.016

Hikida M, Casola S, Takahashi N, Kaji T, Takemori T, Rajewsky K, Kurosaki T

PLC-gamma2 is essential for formation and maintenance of memory B cells.

J Exp Med 2009; 681-9. doi: 10.1084/jem.20082100

De Santa F, Narang V, Yap ZH, Tusi BK, Burgold T, Austenaa L, Bucci G, Caganova M, Notarbartolo S, Casola S, Testa G, Sung WK, Wei CL, Natoli G

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages.

EMBO J 2009; 3341-52. doi: 10.1038/emboj.2009.271

Omodei D, Acampora D, Russo F, De Filippi R, Severino V, Di Francia R, Frigeri F, Mancuso P, De Chiara A, Pinto A, Casola S, Simeone A

Expression of the brain transcription factor OTX1 occurs in a subset of normal germinal-center B cells and in aggressive Non-Hodgkin Lymphoma.

Am J Pathol 2009; 2609-17. doi: 10.2353/ajpath.2009.090542

Pasi CE, Dereli-Öz A, Negrini S, Friedli M, Fragola G, Lombardo A, Van Houwe G, Naldini L, Casola S, Testa G, Trono D, Pelicci PG, Halazonetis TD

Genomic instability in induced stem cells.

Cell Death Differ 2011; 745-53. doi: 10.1038/cdd.2011.9

Sakurai N, Maeda M, Lee SU, Ishikawa Y, Li M, Williams JC, Wang L, Su L, Suzuki M, Saito TI, Chiba S, Casola S, Yagita H, Teruya-Feldstein J, Tsuzuki S, Bhatia R, Maeda T

The LRF transcription factor regulates mature B cell development and the germinal center response in mice.

J Clin Invest 2011; 2583-98. doi: 10.1172/JCI45682

Zhang B, Kracker S, Yasuda T, Casola S, Vanneman M, Hömig-Hölzel C, Wang Z, Derudder E, Li S, Chakraborty T, Cotter SE, Koyama S, Currie T, Freeman GJ, Kutok JL, Rodig SJ, Dranoff G, Rajewsky K

Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model.

Cell 2012; 739-51. doi: 10.1016/j.cell.2011.12.031

Burgold T, Voituron N, Caganova M, Tripathi PP, Menuet C, Tusi BK, Spreafico F, Bévengut M, Gestreau C, Buontempo S, Simeone A, Kruidenier L, Natoli G, Casola S, Hilaire G, Testa G

The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival.

Cell Rep 2012; 1244-58. doi: 10.1016/j.celrep.2012.09.013

Pozzi B, Amodio S, Lucano C, Sciullo A, Ronzoni S, Castelletti D, Adler T, Treise I, Betsholtz IH, Rathkolb B, Busch DH, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Betsholtz C, Casola S, Di Fiore PP, Offenhäuser N

The endocytic adaptor Eps15 controls marginal zone B cell numbers.

PLoS One 2012; e50818. doi: 10.1371/journal.pone.0050818

Lechouane F, Bonaud A, Delpy L, Casola S, Oruc Z, Chemin G, Cogné M, Sirac C

B-cell receptor signal strength influences terminal differentiation.

Eur J Immunol 2013; 619-28. doi: 10.1002/eji.201242912

Pengo N, Scolari M, Oliva L, Milan E, Mainoldi F, Raimondi A, Fagioli C, Merlini A, Mariani E, Pasqualetto E, Orfanelli U, Ponzoni M, Sitia R, Casola S, Cenci S

Plasma cells require autophagy for sustainable immunoglobulin production.

Nat Immunol 2013; 298-305. doi: 10.1038/ni.2524

Fragola G, Germain PL, Laise P, Cuomo A, Blasimme A, Gross F, Signaroldi E, Bucci G, Sommer C, Pruneri G, Mazzarol G, Bonaldi T, Mostoslavsky G, Casola S, Testa G

Cell reprogramming requires silencing of a core subset of polycomb targets.

PLoS Genet 2013; e1003292. doi: 10.1371/journal.pgen.1003292

Caganova M, Carrisi C, Varano G, Mainoldi F, Zanardi F, Germain PL, George L, Alberghini F, Ferrarini L, Talukder AK, Ponzoni M, Testa G, Nojima T, Doglioni C, Kitamura D, Toellner KM, Su IH, Casola S

Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis.

J Clin Invest 2013; 5009-22. doi: 10.1172/JCI70626

Simonetti G, Bertilaccio MT, Rodriguez TV, Apollonio B, Dagklis A, Rocchi M, Innocenzi A, Casola S, Winkler TH, Nitschke L, Ponzoni M, Caligaris-Cappio F, Ghia P

SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.

Haematologica 2014; 1356-64. doi: 10.3324/haematol.2013.100230

Alberghini F, Petrocelli V, Rahmat M, Casola S

An epigenetic view of B-cell disorders.

Immunol Cell Biol 2015; 253-60. doi: 10.1038/icb.2014.116

Kumar R, Bach MP, Mainoldi F, Maruya M, Kishigami S, Jumaa H, Wakayama T, Kanagawa O, Fagarasan S, Casola S

Antibody repertoire diversification through VH gene replacement in mice cloned from an IgA plasma cell.

Proc Natl Acad Sci U S A 2015; E450-7. doi: 10.1073/pnas.1417988112

Mihailovich M, Bremang M, Spadotto V, Musiani D, Vitale E, Varano G, Zambelli F, Mancuso FM, Cairns DA, Pavesi G, Casola S, Bonaldi T

miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth.

Nat Commun 2015; 8725. doi: 10.1038/ncomms9725

Wanke F, Moos S, Croxford AL, Heinen AP, Gräf S, Kalt B, Tischner D, Zhang J, Christen I, Bruttger J, Yogev N, Tang Y, Zayoud M, Israel N, Karram K, Reißig S, Lacher SM, Reichhold C, Mufazalov IA, Ben-Nun A, Kuhlmann T, Wettschureck N, Sailer AW, Rajewsky K, Casola S, Waisman A, Kurschus FC

EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells.

Cell Rep 2017; 1270-1284. doi: 10.1016/j.celrep.2017.01.020

Varano G, Raffel S, Sormani M, Zanardi F, Lonardi S, Zasada C, Perucho L, Petrocelli V, Haake A, Lee AK, Bugatti M, Paul U, Van Anken E, Pasqualucci L, Rabadan R, Siebert R, Kempa S, Ponzoni M, Facchetti F, Rajewsky K, Casola S

The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.

Nature 2017; 302-306. doi: 10.1038/nature22353

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