Puddu F, Salguero I, Herzog M, Geisler NJ, Costanzo V, Jackson SP

Chromatin determinants impart camptothecin sensitivity.

EMBO Rep 2017; 1000-1012. doi: 10.15252/embr.201643560

Kolinjivadi AM, Sannino V, De Antoni A, Zadorozhny K, Kilkenny M, Técher H, Baldi G, Shen R, Ciccia A, Pellegrini L, Krejci L, Costanzo V

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.

Mol Cell 2017; 867-881.e7. doi: 10.1016/j.molcel.2017.07.001

Coquel F, Silva MJ, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, Promonet A, Cribier A, Sarrazin A, Niedzwiedz W, Lopez B, Costanzo V, Krejci L, Chabes A, Benkirane M, Lin YL, Pasero P

SAMHD1 acts at stalled replication forks to prevent interferon induction.

Nature 2018; 57-61. doi: 10.1038/s41586-018-0050-1

Srinivasan M, Scheinost JC, Petela NJ, Gligoris TG, Wissler M, Ogushi S, Collier JE, Voulgaris M, Kurze A, Chan KL, Hu B, Costanzo V, Nasmyth KA

The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as well as Topological Mechanisms.

Cell 2018; 1508-1519.e18. doi: 10.1016/j.cell.2018.04.015

Ercilla A, Benada J, Amitash S, Zonderland G, Baldi G, Somyajit K, Ochs F, Costanzo V, Lukas J, Toledo L

Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication.

Cell Rep 2020; 2416-2429.e7. doi: 10.1016/j.celrep.2020.01.067

Coquel F, Silva MJ, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, Promonet A, Cribier A, Sarrazin A, Niedzwiedz W, Lopez B, Costanzo V, Krejci L, Chabes A, Benkirane M, Lin YL, Pasero P

[SAMHD1 acts at stalled replication forks to prevent interferon induction].

C R Biol 2020; 9-21. doi: 10.5802/crbiol.10

Mann A, Ramirez-Otero MA, De Antoni A, Hanthi YW, Sannino V, Baldi G, Falbo L, Schrempf A, Bernardo S, Loizou J, Costanzo V

POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps.

Mol Cell 2022; 4218-4231.e8. doi: 10.1016/j.molcel.2022.09.013

Schrempf A, Bernardo S, Arasa Verge EA, Ramirez Otero MA, Wilson J, Kirchhofer D, Timelthaler G, Ambros AM, Kaya A, Wieder M, Ecker GF, Winter GE, Costanzo V, Loizou JI

POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells.

Cell Rep 2022; 111716. doi: 10.1016/j.celrep.2022.111716

Lewis M, Terré B, Knobel PA, Cheng T, Lu H, Attolini CS, Smak J, Coyaud E, Garcia-Cao I, Sharma S, Vineethakumari C, Querol J, Gil-Gómez G, Piergiovanni G, Costanzo V, Peiró S, Raught B, Zhao H, Salvatella X, Roy S, Mahjoub MR, Stracker TH

GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program.

Cell Death Dis 2023; 201. doi: 10.1038/s41419-023-05720-4

Moore CE, Yalcindag SE, Czeladko H, Ravindranathan R, Wijesekara Hanthi Y, Levy JC, Sannino V, Schindler D, Ciccia A, Costanzo V, Elia AEH

RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of stalled replication forks.

J Cell Biol 2023; . doi: 10.1083/jcb.202106022

Hanthi YW, Ramirez-Otero MA, Appleby R, De Antoni A, Joudeh L, Sannino V, Waked S, Ardizzoia A, Barra V, Fachinetti D, Pellegrini L, Costanzo V

RAD51 protects abasic sites to prevent replication fork breakage.

Mol Cell 2024; 3026-3043.e11. doi: 10.1016/j.molcel.2024.07.004

Peña-Gómez MJ, Rodríguez-Martín Y, Del Rio Oliva M, Wijesekara Hanthi Y, Berrada S, Freire R, Masson JY, Reyes JC, Costanzo V, Rosado IV

HMCES corrupts replication fork stability during base excision repair in homologous recombination-deficient cells.

Sci Adv 2025; eads3227. doi: 10.1126/sciadv.ads3227

Zribi S, Giannitelli GJ, Bernardini L, Censi F, Camerini S, Bertuccini L, Iosi F, Giannella E, Sanchez M, Consoli E, Casagrande A, Cenci A, Floridia G, Novelli A, Giuliani A, Costanzo V, Crescenzi M, Pajalunga D

Structural obstruction to full DNA replication in terminally differentiated skeletal muscle cells.

EMBO Rep 2025; 4633-4655. doi: 10.1038/s44319-025-00554-x

Vinciguerra M, El Kharef C, Bruhn C, Falbo L, Milanese C, Audano M, Beznoussenko GV, Mironov AA, Delia D, Foiani M, Mastroberardino PG, Mitro N, Costanzo V

Targeting the FNIP2-SERCA2b axis improves metabolic and mitochondrial defects in Ataxia Telangiectasia.

Cell Death Dis 2026; . doi: 10.1038/s41419-026-08507-5

Mazzucco G, Huda A, Galli M, Piccini D, Giannattasio M, Pessina F, Doksani Y

Telomere damage induces internal loops that generate telomeric circles.

Nat Commun 2020; 5297. doi: 10.1038/s41467-020-19139-4

Gamba R, Mazzucco G, Wilhelm T, Velikovsky L, Salinas-Luypaert C, Chardon F, Picotto J, Bohec M, Baulande S, Doksani Y, Fachinetti D

Enrichment of centromeric DNA from human cells.

PLoS Genet 2022; e1010306. doi: 10.1371/journal.pgen.1010306

Garribba L, De Feudis G, Martis V, Galli M, Dumont M, Eliezer Y, Wardenaar R, Ippolito MR, Iyer DR, Tijhuis AE, Spierings DCJ, Schubert M, Taglietti S, Soriani C, Gemble S, Basto R, Rhind N, Foijer F, Ben-David U, Fachinetti D, Doksani Y, Santaguida S

Short-term molecular consequences of chromosome mis-segregation for genome stability.

Nat Commun 2023; 1353. doi: 10.1038/s41467-023-37095-7

Pessina F, Romussi A, Piccini D, Mazzucco G, Varasi M, Doksani Y

Enrichment of DNA replication intermediates by EdU pull down.

Methods Cell Biol 2024; 83-94. doi: 10.1016/bs.mcb.2022.11.001

Vaurs M, Claude E, Zanella E, Rodrigues J, Nassour J, Karlseder J, Azzalin CM, Doksani Y, Decottignies A

TRF1 relies on fork reversal to prevent fragility at human telomeres.

Nat Commun 2025; 6439. doi: 10.1038/s41467-025-61828-5

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