Gee HE, Camps C, Buffa FM, Colella S, Sheldon H, Gleadle JM, Ragoussis J, Harris AL

MicroRNA-10b and breast cancer metastasis.

Nature 2008; E8-9; author reply E9. doi: 10.1038/nature07362

Starmans MH, Krishnapuram B, Steck H, Horlings H, Nuyten DS, van de Vijver MJ, Seigneuric R, Buffa FM, Harris AL, Wouters BG, Lambin P

Robust prognostic value of a knowledge-based proliferation signature across large patient microarray studies spanning different cancer types.

Br J Cancer 2008; 1884-90. doi: 10.1038/sj.bjc.6604746

Generali D, Buffa FM, Berruti A, Brizzi MP, Campo L, Bonardi S, Bersiga A, Allevi G, Milani M, Aguggini S, Papotti M, Dogliotti L, Bottini A, Harris AL, Fox SB

Phosphorylated ERalpha, HIF-1alpha, and MAPK signaling as predictors of primary endocrine treatment response and resistance in patients with breast cancer.

J Clin Oncol 2009; 227-34. doi: 10.1200/JCO.2007.13.7083

Guerrero Urbano T, Khoo V, Staffurth J, Norman A, Buffa F, Jackson A, Adams E, Hansen V, Clark C, Miles E, McNair H, Nutting C, Parker C, Eeles R, Huddart R, Horwich A, Dearnaley DP

Intensity-modulated radiotherapy allows escalation of the radiation dose to the pelvic lymph nodes in patients with locally advanced prostate cancer: preliminary results of a phase I dose escalation study.

Clin Oncol (R Coll Radiol) 2010; 236-44. doi: 10.1016/j.clon.2010.01.005

Gee HE, Camps C, Buffa FM, Patiar S, Winter SC, Betts G, Homer J, Corbridge R, Cox G, West CM, Ragoussis J, Harris AL

hsa-mir-210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer.

Cancer 2010; 2148-58. doi: 10.1002/cncr.25009

Favaro E, Ramachandran A, McCormick R, Gee H, Blancher C, Crosby M, Devlin C, Blick C, Buffa F, Li JL, Vojnovic B, Pires das Neves R, Glazer P, Iborra F, Ivan M, Ragoussis J, Harris AL

MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU.

PLoS One 2010; e10345. doi: 10.1371/journal.pone.0010345

Thurlow JK, Peña Murillo CL, Hunter KD, Buffa FM, Patiar S, Betts G, West CM, Harris AL, Parkinson EK, Harrison PR, Ozanne BW, Partridge M, Kalna G

Spectral clustering of microarray data elucidates the roles of microenvironment remodeling and immune responses in survival of head and neck squamous cell carcinoma.

J Clin Oncol 2010; 2881-8. doi: 10.1200/JCO.2009.24.8724

Rzymski T, Milani M, Pike L, Buffa F, Mellor HR, Winchester L, Pires I, Hammond E, Ragoussis I, Harris AL

Regulation of autophagy by ATF4 in response to severe hypoxia.

Oncogene 2010; 4424-35. doi: 10.1038/onc.2010.191

McCormick R, Buffa FM, Ragoussis J, Harris AL

The role of hypoxia regulated microRNAs in cancer.

Curr Top Microbiol Immunol 2010; 47-70. doi: 10.1007/82_2010_76

Hannigan A, Smith P, Kalna G, Lo Nigro C, Orange C, O'Brien DI, Shah R, Syed N, Spender LC, Herrera B, Thurlow JK, Lattanzio L, Monteverde M, Maurer ME, Buffa FM, Mann J, Chu DC, West CM, Patridge M, Oien KA, Cooper JA, Frame MC, Harris AL, Hiller L, Nicholson LJ, Gasco M, Crook T, Inman GJ

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

J Clin Invest 2010; 2842-57. doi: 10.1172/JCI36125

Higgins GS, Harris AL, Prevo R, Helleday T, McKenna WG, Buffa FM

Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

Oncotarget 2010; 175-84. doi: 10.18632/oncotarget.124

Moskwa P, Buffa FM, Pan Y, Panchakshari R, Gottipati P, Muschel RJ, Beech J, Kulshrestha R, Abdelmohsen K, Weinstock DM, Gorospe M, Harris AL, Helleday T, Chowdhury D

miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors.

Mol Cell 2011; 210-20. doi: 10.1016/j.molcel.2010.12.005

Ghazoui Z, Buffa FM, Dunbier AK, Anderson H, Dexter T, Detre S, Salter J, Smith IE, Harris AL, Dowsett M

Close and stable relationship between proliferation and a hypoxia metagene in aromatase inhibitor-treated ER-positive breast cancer.

Clin Cancer Res 2011; 3005-12. doi: 10.1158/1078-0432.CCR-10-1704

Kawabe Yi, Branzei D, Hayashi T, Suzuki H, Masuko T, Onoda F, Heo SJ, Ikeda H, Shimamoto A, Furuichi Y, Seki M, Enomoto T

A novel protein interacts with the Werner's syndrome gene product physically and functionally.

J Biol Chem 2001; 20364-9. doi: 10.1074/jbc.C100035200

Gee HE, Buffa FM, Camps C, Ramachandran A, Leek R, Taylor M, Patil M, Sheldon H, Betts G, Homer J, West C, Ragoussis J, Harris AL

The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis.

Br J Cancer 2011; 1168-77. doi: 10.1038/sj.bjc.6606076

Coutts AS, Pires IM, Weston L, Buffa FM, Milani M, Li JL, Harris AL, Hammond EM, La Thangue NB

Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α.

Oncogene 2011; 4835-42. doi: 10.1038/onc.2011.188

Korpal M, Ell BJ, Buffa FM, Ibrahim T, Blanco MA, Celià-Terrassa T, Mercatali L, Khan Z, Goodarzi H, Hua Y, Wei Y, Hu G, Garcia BA, Ragoussis J, Amadori D, Harris AL, Kang Y

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization.

Nat Med 2011; 1101-8. doi: 10.1038/nm.2401

Favaro E, Lord S, Harris AL, Buffa FM

Gene expression and hypoxia in breast cancer.

Genome Med 2011; 55. doi: 10.1186/gm271

Martin L, Anguita A, Graf N, Tsiknakis M, Brochhausen M, Rüping S, Bucur A, Sfakianakis S, Sengstag T, Buffa F, Stenzhorn H

ACGT: advancing clinico-genomic trials on cancer - four years of experience.

Stud Health Technol Inform 2011; 734-8.

Mehta S, Hughes NP, Buffa FM, Li SP, Adams RF, Adwani A, Taylor NJ, Levitt NC, Padhani AR, Makris A, Harris AL

Assessing early therapeutic response to bevacizumab in primary breast cancer using magnetic resonance imaging and gene expression profiles.

J Natl Cancer Inst Monogr 2011; 71-4. doi: 10.1093/jncimonographs/lgr027

Church DN, Phillips BR, Stuckey DJ, Barnes DJ, Buffa FM, Manek S, Clarke K, Harris AL, Carter EJ, Hassan AB

Igf2 ligand dependency of Pten(+/-) developmental and tumour phenotypes in the mouse.

Oncogene 2012; 3635-46. doi: 10.1038/onc.2011.526

Yang J, Staples O, Thomas LW, Briston T, Robson M, Poon E, Simões ML, El-Emir E, Buffa FM, Ahmed A, Annear NP, Shukla D, Pedley BR, Maxwell PH, Harris AL, Ashcroft M

Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression.

J Clin Invest 2012; 600-11. doi: 10.1172/JCI58780

Betts GN, Eustace A, Patiar S, Valentine HR, Irlam J, Ramachandran A, Merve A, Homer JJ, Möller-Levet C, Buffa FM, Hall G, Miller CJ, Harris AL, West CM

Prospective technical validation and assessment of intra-tumour heterogeneity of a low density array hypoxia gene profile in head and neck squamous cell carcinoma.

Eur J Cancer 2013; 156-65. doi: 10.1016/j.ejca.2012.07.028

Jones DT, Lechertier T, Mitter R, Herbert JM, Bicknell R, Jones JL, Li JL, Buffa F, Harris AL, Hodivala-Dilke K

Gene expression analysis in human breast cancer associated blood vessels.

PLoS One 2012; e44294. doi: 10.1371/journal.pone.0044294

Pike LR, Singleton DC, Buffa F, Abramczyk O, Phadwal K, Li JL, Simon AK, Murray JT, Harris AL

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival.

Biochem J 2013; 389-400. doi: 10.1042/BJ20120972

Favaro E, Bensaad K, Chong MG, Tennant DA, Ferguson DJ, Snell C, Steers G, Turley H, Li JL, Günther UL, Buffa FM, McIntyre A, Harris AL

Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells.

Cell Metab 2012; 751-64. doi: 10.1016/j.cmet.2012.10.017

Ramachandran A, Betts G, Bhana S, Helme G, Blick C, Moller-Levet C, Saunders E, Valentine H, Pepper S, Miller CJ, Buffa F, Harris AL, West CM

An in vivo hypoxia metagene identifies the novel hypoxia inducible factor target gene SLCO1B3.

Eur J Cancer 2013; 1741-51. doi: 10.1016/j.ejca.2012.12.003

Kumar K, Wigfield S, Gee HE, Devlin CM, Singleton D, Li JL, Buffa F, Huffman M, Sinn AL, Silver J, Turley H, Leek R, Harris AL, Ivan M

Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts.

J Mol Med (Berl) 2013; 749-58. doi: 10.1007/s00109-013-0996-2

Blick C, Ramachandran A, Wigfield S, McCormick R, Jubb A, Buffa FM, Turley H, Knowles MA, Cranston D, Catto J, Harris AL

Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer.

Br J Cancer 2013; 50-9. doi: 10.1038/bjc.2013.240

Eustace A, Mani N, Span PN, Irlam JJ, Taylor J, Betts GN, Denley H, Miller CJ, Homer JJ, Rojas AM, Hoskin PJ, Buffa FM, Harris AL, Kaanders JH, West CM

A 26-gene hypoxia signature predicts benefit from hypoxia-modifying therapy in laryngeal cancer but not bladder cancer.

Clin Cancer Res 2013; 4879-88. doi: 10.1158/1078-0432.CCR-13-0542

Masiero M, Simões FC, Han HD, Snell C, Peterkin T, Bridges E, Mangala LS, Wu SY, Pradeep S, Li D, Han C, Dalton H, Lopez-Berestein G, Tuynman JB, Mortensen N, Li JL, Patient R, Sood AK, Banham AH, Harris AL, Buffa FM

A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.

Cancer Cell 2013; 229-41. doi: 10.1016/j.ccr.2013.06.004

Camps C, Saini HK, Mole DR, Choudhry H, Reczko M, Guerra-Assunção JA, Tian YM, Buffa FM, Harris AL, Hatzigeorgiou AG, Enright AJ, Ragoussis J

Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia.

Mol Cancer 2014; 28. doi: 10.1186/1476-4598-13-28

Generali D, Buffa FM, Deb S, Cummings M, Reid LE, Taylor M, Andreis D, Allevi G, Ferrero G, Byrne D, Martinotti M, Bottini A, Harris AL, Lakhani SR, Fox SB

COX-2 expression is predictive for early relapse and aromatase inhibitor resistance in patients with ductal carcinoma in situ of the breast, and is a target for treatment.

Br J Cancer 2014; 46-54. doi: 10.1038/bjc.2014.236

Bensaad K, Favaro E, Lewis CA, Peck B, Lord S, Collins JM, Pinnick KE, Wigfield S, Buffa FM, Li JL, Zhang Q, Wakelam MJO, Karpe F, Schulze A, Harris AL

Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation.

Cell Rep 2014; 349-365. doi: 10.1016/j.celrep.2014.08.056

Pettersen EO, Ebbesen P, Gieling RG, Williams KJ, Dubois L, Lambin P, Ward C, Meehan J, Kunkler IH, Langdon SP, Ree AH, Flatmark K, Lyng H, Calzada MJ, Peso LD, Landazuri MO, Görlach A, Flamm H, Kieninger J, Urban G, Weltin A, Singleton DC, Haider S, Buffa FM, Harris AL, Scozzafava A, Supuran CT, Moser I, Jobst G, Busk M, Toustrup K, Overgaard J, Alsner J, Pouyssegur J, Chiche J, Mazure N, Marchiq I, Parks S, Ahmed A, Ashcroft M, Pastorekova S, Cao Y, Rouschop KM, Wouters BG, Koritzinsky M, Mujcic H, Cojocari D

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.

J Enzyme Inhib Med Chem 2015; 689-721. doi: 10.3109/14756366.2014.966704

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