Moreno García V, Olmos D, Gomez-Roca C, Cassier PA, Morales-Barrera R, Del Conte G, Gallerani E, Brunetto AT, Schöffski P, Marsoni S, Schellens JH, Penel N, Voest E, Evans J, Plummer R, Wilson RH, Soria JC, Tabernero J, Verweij J, Kaye SB

Dose-response relationship in phase i clinical trials: a European Drug Development Network (EDDN) Collaboration Study.

Clin Cancer Res 2014; 5663-71. doi: 10.1158/1078-0432.CCR-14-0719

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Basile G, Leuzzi G, Pichierri P, Franchitto A

Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress.

Nucleic Acids Res 2014; 12628-39. doi: 10.1093/nar/gku1022

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Laginestra MA, Piccaluga PP, Fuligni F, Rossi M, Agostinelli C, Righi S, Sapienza MR, Motta G, Gazzola A, Mannu C, Sabattini E, Bacci F, Tabanelli V, Sacchetti CA, Barrese TZ, Etebari M, Melle F, Clò A, Gibellini D, Tripodo C, Inghirami G, Croce CM, Pileri SA

Pathogenetic and diagnostic significance of microRNA deregulation in peripheral T-cell lymphoma not otherwise specified.

Blood Cancer J 2014; 259. doi: 10.1038/bcj.2014.78

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Mari S, Ruetalo N, Maspero E, Stoffregen MC, Pasqualato S, Polo S, Wiesner S

Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases.

Structure 2014; 1639-49. doi: 10.1016/j.str.2014.09.006

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Misale S, Di Nicolantonio F, Sartore-Bianchi A, Siena S, Bardelli A

Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution.

Cancer Discov 2014; 1269-80. doi: 10.1158/2159-8290.CD-14-0462

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Sorrentino G, Comel A, Mantovani F, Del Sal G

Regulation of mitochondrial apoptosis by Pin1 in cancer and neurodegeneration.

Mitochondrion 2014; 88-96. doi: 10.1016/j.mito.2014.08.003

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Piconese S, Timperi E, Pacella I, Schinzari V, Tripodo C, Rossi M, Guglielmo N, Mennini G, Grazi GL, Di Filippo S, Brozzetti S, Fazzi K, Antonelli G, Lozzi MA, Sanchez M, Barnaba V

Human OX40 tunes the function of regulatory T cells in tumor and nontumor areas of hepatitis C virus-infected liver tissue.

Hepatology 2014; 1494-507. doi: 10.1002/hep.27188

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Mion F, D'Incà F, Danelli L, Toffoletto B, Guarnotta C, Frossi B, Burocchi A, Rigoni A, Gerdes N, Lutgens E, Tripodo C, Colombo MP, Rivera J, Vitale G, Pucillo CE

Mast cells control the expansion and differentiation of IL-10-competent B cells.

J Immunol 2014; 4568-79. doi: 10.4049/jimmunol.1302593

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van den Beucken T, Koch E, Chu K, Rupaimoole R, Prickaerts P, Adriaens M, Voncken JW, Harris AL, Buffa FM, Haider S, Starmans MHW, Yao CQ, Ivan M, Ivan C, Pecot CV, Boutros PC, Sood AK, Koritzinsky M, Wouters BG

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

Nat Commun 2014; 5203. doi: 10.1038/ncomms6203

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Cossetti C, Iraci N, Mercer TR, Leonardi T, Alpi E, Drago D, Alfaro-Cervello C, Saini HK, Davis MP, Schaeffer J, Vega B, Stefanini M, Zhao C, Muller W, Garcia-Verdugo JM, Mathivanan S, Bachi A, Enright AJ, Mattick JS, Pluchino S

Extracellular vesicles from neural stem cells transfer IFN-γ via Ifngr1 to activate Stat1 signaling in target cells.

Mol Cell 2014; 193-204. doi: 10.1016/j.molcel.2014.08.020

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Long Z, Olliver A, Brambilla E, Sclavi B, Lagomarsino MC, Dorfman KD

Measuring bacterial adaptation dynamics at the single-cell level using a microfluidic chemostat and time-lapse fluorescence microscopy.

Analyst 2014; 5254-62. doi: 10.1039/c4an00877d

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Crespo CL, Vernieri C, Keller PJ, Garrè M, Bender JR, Wittbrodt J, Pardi R

The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes.

J Cell Sci 2014; 4381-95. doi: 10.1242/jcs.146217

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Bensaad K, Favaro E, Lewis CA, Peck B, Lord S, Collins JM, Pinnick KE, Wigfield S, Buffa FM, Li JL, Zhang Q, Wakelam MJO, Karpe F, Schulze A, Harris AL

Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation.

Cell Rep 2014; 349-365. doi: 10.1016/j.celrep.2014.08.056

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Antonelli R, Pizzarelli R, Pedroni A, Fritschy JM, Del Sal G, Cherubini E, Zacchi P

Pin1-dependent signalling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interaction.

Nat Commun 2014; 5066. doi: 10.1038/ncomms6066

Leggi ora

Persaud A, Alberts P, Mari S, Tong J, Murchie R, Maspero E, Safi F, Moran MF, Polo S, Rotin D

Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity.

Sci Signal 2014; ra95. doi: 10.1126/scisignal.2005290

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Abe T, Branzei D

High levels of BRC4 induced by a Tet-On 3G system suppress DNA repair and impair cell proliferation in vertebrate cells.

DNA Repair (Amst) 2014; 153-64. doi: 10.1016/j.dnarep.2014.08.003

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Lackner DH, Hayashi MT, Cesare AJ, Karlseder J

A genomics approach identifies senescence-specific gene expression regulation.

Aging Cell 2014; 946-50. doi: 10.1111/acel.12234

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Giannattasio M, Zwicky K, Follonier C, Foiani M, Lopes M, Branzei D

Visualization of recombination-mediated damage bypass by template switching.

Nat Struct Mol Biol 2014; 884-92. doi: 10.1038/nsmb.2888

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Piccolo S

Yoshiki Sasai: stem cell Sensei.

Development 2014; 3613-4. doi: 10.1242/dev.116509

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Piccolo S, Dupont S, Cordenonsi M

The biology of YAP/TAZ: hippo signaling and beyond.

Physiol Rev 2014; 1287-312. doi: 10.1152/physrev.00005.2014

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Piccolo S

Twists of fate.

Sci Am 2014; 74-81. doi: 10.1038/scientificamerican1014-74

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Marino MT, Grilli A, Baricordi C, Manara MC, Ventura S, Pinca RS, Bellenghi M, Calvaruso M, Mattia G, Donati D, Tripodo C, Picci P, Ferrari S, Scotlandi K

Prognostic significance of miR-34a in Ewing sarcoma is associated with cyclin D1 and ki-67 expression.

Ann Oncol 2014; 2080-2086. doi: 10.1093/annonc/mdu249

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Bleeker FE, Lamba S, Zanon C, Molenaar RJ, Hulsebos TJ, Troost D, van Tilborg AA, Vandertop WP, Leenstra S, van Noorden CJ, Bardelli A

Mutational profiling of kinases in glioblastoma.

BMC Cancer 2014; 718. doi: 10.1186/1471-2407-14-718

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Doksani Y, de Lange T

The role of double-strand break repair pathways at functional and dysfunctional telomeres.

Cold Spring Harb Perspect Biol 2014; a016576. doi: 10.1101/cshperspect.a016576

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Van Emburgh BO, Sartore-Bianchi A, Di Nicolantonio F, Siena S, Bardelli A

Acquired resistance to EGFR-targeted therapies in colorectal cancer.

Mol Oncol 2014; 1084-94. doi: 10.1016/j.molonc.2014.05.003

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Lamba S, Russo M, Sun C, Lazzari L, Cancelliere C, Grernrum W, Lieftink C, Bernards R, Di Nicolantonio F, Bardelli A

RAF suppression synergizes with MEK inhibition in KRAS mutant cancer cells.

Cell Rep 2014; 1475-83. doi: 10.1016/j.celrep.2014.07.033

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Noris M, Galbusera M, Gastoldi S, Macor P, Banterla F, Bresin E, Tripodo C, Bettoni S, Donadelli R, Valoti E, Tedesco F, Amore A, Coppo R, Ruggenenti P, Gotti E, Remuzzi G

Dynamics of complement activation in aHUS and how to monitor eculizumab therapy.

Blood 2014; 1715-26. doi: 10.1182/blood-2014-02-558296

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Rolland Y, Marighetti P, Malinverno C, Confalonieri S, Luise C, Ducano N, Palamidessi A, Bisi S, Kajiho H, Troglio F, Shcherbakova OG, Dunn AR, Oldani A, Lanzetti L, Di Fiore PP, Disanza A, Scita G

The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination.

Dev Cell 2014; 553-68. doi: 10.1016/j.devcel.2014.08.006

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Molenaar RJ, Verbaan D, Lamba S, Zanon C, Jeuken JW, Boots-Sprenger SH, Wesseling P, Hulsebos TJ, Troost D, van Tilborg AA, Leenstra S, Vandertop WP, Bardelli A, van Noorden CJ, Bleeker FE

The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone.

Neuro Oncol 2014; 1263-73. doi: 10.1093/neuonc/nou005

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Molfetta R, Quatrini L, Capuano C, Gasparrini F, Zitti B, Zingoni A, Galandrini R, Santoni A, Paolini R

c-Cbl regulates MICA- but not ULBP2-induced NKG2D down-modulation in human NK cells.

Eur J Immunol 2014; 2761-70. doi: 10.1002/eji.201444512

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Kramarz K, Litwin I, Cal-Bąkowska M, Szakal B, Branzei D, Wysocki R, Dziadkowiec D

Swi2/Snf2-like protein Uls1 functions in the Sgs1-dependent pathway of maintenance of rDNA stability and alleviation of replication stress.

DNA Repair (Amst) 2014; 24-35. doi: 10.1016/j.dnarep.2014.05.008

Leggi ora

Mandrà S, Lagomarsino MC, Gherardi M

Soft bounds on diffusion produce skewed distributions and Gompertz growth.

Phys Rev E Stat Nonlin Soft Matter Phys 2014; 032805. doi: 10.1103/PhysRevE.90.032805

Leggi ora

Sangaletti S, Tripodo C, Sandri S, Torselli I, Vitali C, Ratti C, Botti L, Burocchi A, Porcasi R, Tomirotti A, Colombo MP, Chiodoni C

Osteopontin shapes immunosuppression in the metastatic niche.

Cancer Res 2014; 4706-19. doi: 10.1158/0008-5472.CAN-13-3334

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Siravegna G, Bardelli A

Genotyping cell-free tumor DNA in the blood to detect residual disease and drug resistance.

Genome Biol 2014; 449. doi: 10.1186/s13059-014-0449-4

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De Grassi A, Iannelli F, Cereda M, Volorio S, Melocchi V, Viel A, Basso G, Laghi L, Caselle M, Ciccarelli FD

Deep sequencing of the X chromosome reveals the proliferation history of colorectal adenomas.

Genome Biol 2014; 437. doi: 10.1186/s13059-014-0437-8

Leggi ora

Comel A, Sorrentino G, Capaci V, Del Sal G

The cytoplasmic side of p53's oncosuppressive activities.

FEBS Lett 2014; 2600-9. doi: 10.1016/j.febslet.2014.04.015

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Simonetti G, Bertilaccio MT, Rodriguez TV, Apollonio B, Dagklis A, Rocchi M, Innocenzi A, Casola S, Winkler TH, Nitschke L, Ponzoni M, Caligaris-Cappio F, Ghia P

SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.

Haematologica 2014; 1356-64. doi: 10.3324/haematol.2013.100230

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Piccolo S

Ever developing TGF-β.

Semin Cell Dev Biol 2014; 71-2. doi: 10.1016/j.semcdb.2014.04.033

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Piccaluga PP, Rossi M, Agostinelli C, Ricci F, Gazzola A, Righi S, Fuligni F, Laginestra MA, Mancini M, Sapienza MR, De Renzo A, Tazzari PL, Gibellini D, Went P, Alviano F, Zinzani PL, Bagnara GP, Inghirami G, Tripodo C, Pileri SA

Platelet-derived growth factor alpha mediates the proliferation of peripheral T-cell lymphoma cells via an autocrine regulatory pathway.

Leukemia 2014; 1687-97. doi: 10.1038/leu.2014.50

Leggi ora

Sapienza MR, Fuligni F, Agostinelli C, Tripodo C, Righi S, Laginestra MA, Pileri A, Mancini M, Rossi M, Ricci F, Gazzola A, Melle F, Mannu C, Ulbar F, Arpinati M, Paulli M, Maeda T, Gibellini D, Pagano L, Pimpinelli N, Santucci M, Cerroni L, Croce CM, Facchetti F, Piccaluga PP, Pileri SA

Molecular profiling of blastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to NF-kB pathway inhibition.

Leukemia 2014; 1606-16. doi: 10.1038/leu.2014.64

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Kumar A, Mazzanti M, Mistrik M, Kosar M, Beznoussenko GV, Mironov AA, Garrè M, Parazzoli D, Shivashankar GV, Scita G, Bartek J, Foiani M

ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress.

Cell 2014; 633-46. doi: 10.1016/j.cell.2014.05.046

Leggi ora

Frittoli E, Palamidessi A, Marighetti P, Confalonieri S, Bianchi F, Malinverno C, Mazzarol G, Viale G, Martin-Padura I, Garré M, Parazzoli D, Mattei V, Cortellino S, Bertalot G, Di Fiore PP, Scita G

A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination.

J Cell Biol 2014; 307-28. doi: 10.1083/jcb.201403127

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Gritenaite D, Princz LN, Szakal B, Bantele SC, Wendeler L, Schilbach S, Habermann BH, Matos J, Lisby M, Branzei D, Pfander B

A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication.

Genes Dev 2014; 1604-19. doi: 10.1101/gad.240515.114

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Restelli M, Lopardo T, Lo Iacono N, Garaffo G, Conte D, Rustighi A, Napoli M, Del Sal G, Perez-Morga D, Costanzo A, Merlo GR, Guerrini L

DLX5, FGF8 and the Pin1 isomerase control ΔNp63α protein stability during limb development: a regulatory loop at the basis of the SHFM and EEC congenital malformations.

Hum Mol Genet 2014; 3830-42. doi: 10.1093/hmg/ddu096

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Generali D, Buffa FM, Deb S, Cummings M, Reid LE, Taylor M, Andreis D, Allevi G, Ferrero G, Byrne D, Martinotti M, Bottini A, Harris AL, Lakhani SR, Fox SB

COX-2 expression is predictive for early relapse and aromatase inhibitor resistance in patients with ductal carcinoma in situ of the breast, and is a target for treatment.

Br J Cancer 2014; 46-54. doi: 10.1038/bjc.2014.236

Leggi ora

Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, Bresolin S, Frasson C, Basso G, Guzzardo V, Fassina A, Cordenonsi M, Piccolo S

YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response.

Cell 2014; 157-70. doi: 10.1016/j.cell.2014.06.013

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