Quatrini L, Molfetta R, Zitti B, Peruzzi G, Fionda C, Capuano C, Galandrini R, Cippitelli M, Santoni A, Paolini R

Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells.

Sci Signal 2015; ra108. doi: 10.1126/scisignal.aab2724

Marabese M, Ganzinelli M, Garassino MC, Shepherd FA, Piva S, Caiola E, Macerelli M, Bettini A, Lauricella C, Floriani I, Farina G, Longo F, Bonomi L, Fabbri MA, Veronese S, Marsoni S, Broggini M, Rulli E

KRAS mutations affect prognosis of non-small-cell lung cancer patients treated with first-line platinum containing chemotherapy.

Oncotarget 2015; 34014-22. doi: 10.18632/oncotarget.5607

Bertotti A, Papp E, Jones S, Adleff V, Anagnostou V, Lupo B, Sausen M, Phallen J, Hruban CA, Tokheim C, Niknafs N, Nesselbush M, Lytle K, Sassi F, Cottino F, Migliardi G, Zanella ER, Ribero D, Russolillo N, Mellano A, Muratore A, Paraluppi G, Salizzoni M, Marsoni S, Kragh M, Lantto J, Cassingena A, Li QK, Karchin R, Scharpf R, Sartore-Bianchi A, Siena S, Diaz LA, Trusolino L, Velculescu VE

The genomic landscape of response to EGFR blockade in colorectal cancer.

Nature 2015; 263-7. doi: 10.1038/nature14969

Harris BH, Barberis A, West CM, Buffa FM

Gene Expression Signatures as Biomarkers of Tumour Hypoxia.

Clin Oncol (R Coll Radiol) 2015; 547-60. doi: 10.1016/j.clon.2015.07.004

Rulli E, Marabese M, Torri V, Farina G, Veronese S, Bettini A, Longo F, Moscetti L, Ganzinelli M, Lauricella C, Copreni E, Labianca R, Martelli O, Marsoni S, Broggini M, Garassino MC

Value of KRAS as prognostic or predictive marker in NSCLC: results from the TAILOR trial.

Ann Oncol 2015; 2079-84. doi: 10.1093/annonc/mdv318

Ferretti E, Di Carlo E, Ognio E, Guarnotta C, Bertoni F, Corcione A, Prigione I, Fraternali-Orcioni G, Ribatti D, Ravetti JL, Ponzoni M, Tripodo C, Pistoia V

Interleukin-17A promotes the growth of human germinal center derived non-Hodgkin B cell lymphoma.

Oncoimmunology 2015; e1030560. doi: 10.1080/2162402X.2015.1030560

Le Noci V, Tortoreto M, Gulino A, Storti C, Bianchi F, Zaffaroni N, Tripodo C, Tagliabue E, Balsari A, Sfondrini L

Poly(I:C) and CpG-ODN combined aerosolization to treat lung metastases and counter the immunosuppressive microenvironment.

Oncoimmunology 2015; e1040214. doi: 10.1080/2162402X.2015.1040214

Prahallad A, Heynen GJ, Germano G, Willems SM, Evers B, Vecchione L, Gambino V, Lieftink C, Beijersbergen RL, Di Nicolantonio F, Bardelli A, Bernards R

PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs.

Cell Rep 2015; 1978-85. doi: 10.1016/j.celrep.2015.08.037

Misale S, Bozic I, Tong J, Peraza-Penton A, Lallo A, Baldi F, Lin KH, Truini M, Trusolino L, Bertotti A, Di Nicolantonio F, Nowak MA, Zhang L, Wood KC, Bardelli A

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.

Nat Commun 2015; 8305. doi: 10.1038/ncomms9305

Poitelon Y, Bogni S, Matafora V, Della-Flora Nunes G, Hurley E, Ghidinelli M, Katzenellenbogen BS, Taveggia C, Silvestri N, Bachi A, Sannino A, Wrabetz L, Feltri ML

Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination.

Nat Commun 2015; 8303. doi: 10.1038/ncomms9303

Rigoni A, Bongiovanni L, Burocchi A, Sangaletti S, Danelli L, Guarnotta C, Lewis A, Rizzo A, Silver AR, Tripodo C, Colombo MP

Mast Cells Infiltrating Inflamed or Transformed Gut Alternatively Sustain Mucosal Healing or Tumor Growth.

Cancer Res 2015; 3760-70. doi: 10.1158/0008-5472.CAN-14-3767

Barault L, Amatu A, Bleeker FE, Moutinho C, Falcomatà C, Fiano V, Cassingena A, Siravegna G, Milione M, Cassoni P, De Braud F, Rudà R, Soffietti R, Venesio T, Bardelli A, Wesseling P, de Witt Hamer P, Pietrantonio F, Siena S, Esteller M, Sartore-Bianchi A, Di Nicolantonio F

Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer.

Ann Oncol 2015; 1994-1999. doi: 10.1093/annonc/mdv272

Zanconato F, Forcato M, Battilana G, Azzolin L, Quaranta E, Bodega B, Rosato A, Bicciato S, Cordenonsi M, Piccolo S

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth.

Nat Cell Biol 2015; 1218-27. doi: 10.1038/ncb3216

Choudhry H, Albukhari A, Morotti M, Haider S, Moralli D, Smythies J, Schödel J, Green CM, Camps C, Buffa F, Ratcliffe P, Ragoussis J, Harris AL, Mole DR

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.

Oncogene 2015; 4482-90. doi: 10.1038/onc.2014.378

Capuani F, Conte A, Argenzio E, Marchetti L, Priami C, Polo S, Di Fiore PP, Sigismund S, Ciliberto A

Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells.

Nat Commun 2015; 7999. doi: 10.1038/ncomms8999

Strauss L, Sangaletti S, Consonni FM, Szebeni G, Morlacchi S, Totaro MG, Porta C, Anselmo A, Tartari S, Doni A, Zitelli F, Tripodo C, Colombo MP, Sica A

RORC1 Regulates Tumor-Promoting "Emergency" Granulo-Monocytopoiesis.

Cancer Cell 2015; 253-69. doi: 10.1016/j.ccell.2015.07.006

Alizadeh AA, Aranda V, Bardelli A, Blanpain C, Bock C, Borowski C, Caldas C, Califano A, Doherty M, Elsner M, Esteller M, Fitzgerald R, Korbel JO, Lichter P, Mason CE, Navin N, Pe'er D, Polyak K, Roberts CW, Siu L, Snyder A, Stower H, Swanton C, Verhaak RG, Zenklusen JC, Zuber J, Zucman-Rossi J

Toward understanding and exploiting tumor heterogeneity.

Nat Med 2015; 846-53. doi: 10.1038/nm.3915

Manfrini N, Clerici M, Wery M, Colombo CV, Descrimes M, Morillon A, d'Adda di Fagagna F, Longhese MP

Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae.

Elife 2015; . doi: 10.7554/eLife.08942

Marjanović M, Sánchez-Huertas C, Terré B, Gómez R, Scheel JF, Pacheco S, Knobel PA, Martínez-Marchal A, Aivio S, Palenzuela L, Wolfrum U, McKinnon PJ, Suja JA, Roig I, Costanzo V, Lüders J, Stracker TH

CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination.

Nat Commun 2015; 7676. doi: 10.1038/ncomms8676

Bonnal RJ, Rossi RL, Carpi D, Ranzani V, Abrignani S, Pagani M

miRiadne: a web tool for consistent integration of miRNA nomenclature.

Nucleic Acids Res 2015; W487-92. doi: 10.1093/nar/gkv381

Siravegna G, Mussolin B, Buscarino M, Corti G, Cassingena A, Crisafulli G, Ponzetti A, Cremolini C, Amatu A, Lauricella C, Lamba S, Hobor S, Avallone A, Valtorta E, Rospo G, Medico E, Motta V, Antoniotti C, Tatangelo F, Bellosillo B, Veronese S, Budillon A, Montagut C, Racca P, Marsoni S, Falcone A, Corcoran RB, Di Nicolantonio F, Loupakis F, Siena S, Sartore-Bianchi A, Bardelli A

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.

Nat Med 2015; 795-801. doi: 10.1038/nm.3870

Bellenghi M, Puglisi R, Pedini F, De Feo A, Felicetti F, Bottero L, Sangaletti S, Errico MC, Petrini M, Gesumundo C, Denaro M, Felli N, Pasquini L, Tripodo C, Colombo MP, Carè A, Mattia G

SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B.

J Pathol 2015; 315-25. doi: 10.1002/path.4535

Kosmalska AJ, Casares L, Elosegui-Artola A, Thottacherry JJ, Moreno-Vicente R, González-Tarragó V, Del Pozo MÁ, Mayor S, Arroyo M, Navajas D, Trepat X, Gauthier NC, Roca-Cusachs P

Physical principles of membrane remodelling during cell mechanoadaptation.

Nat Commun 2015; 7292. doi: 10.1038/ncomms8292

Matafora V, Cuccurullo M, Beneduci A, Petrazzuolo O, Simeone A, Anastasio P, Mignani R, Feriozzi S, Pisani A, Comotti C, Bachi A, Capasso G

Early markers of Fabry disease revealed by proteomics.

Mol Biosyst 2015; 1543-51. doi: 10.1039/c4mb00707g

Leszczynska KB, Foskolou IP, Abraham AG, Anbalagan S, Tellier C, Haider S, Span PN, O'Neill EE, Buffa FM, Hammond EM

Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT.

J Clin Invest 2015; 2385-98. doi: 10.1172/JCI80402

Vitali C, Bassani C, Chiodoni C, Fellini E, Guarnotta C, Miotti S, Sangaletti S, Fuligni F, De Cecco L, Piccaluga PP, Colombo MP, Tripodo C

SOCS2 Controls Proliferation and Stemness of Hematopoietic Cells under Stress Conditions and Its Deregulation Marks Unfavorable Acute Leukemias.

Cancer Res 2015; 2387-99. doi: 10.1158/0008-5472.CAN-14-3625

Jachetti E, Caputo S, Mazzoleni S, Brambillasca CS, Parigi SM, Grioni M, Piras IS, Restuccia U, Calcinotto A, Freschi M, Bachi A, Galli R, Bellone M

Tenascin-C Protects Cancer Stem-like Cells from Immune Surveillance by Arresting T-cell Activation.

Cancer Res 2015; 2095-108. doi: 10.1158/0008-5472.CAN-14-2346

Xue X, Choi K, Bonner JN, Szakal B, Chen YH, Papusha A, Saro D, Niu H, Ira G, Branzei D, Sung P, Zhao X

Selective modulation of the functions of a conserved DNA motor by a histone fold complex.

Genes Dev 2015; 1000-5. doi: 10.1101/gad.259143.115

Meena JK, Cerutti A, Beichler C, Morita Y, Bruhn C, Kumar M, Kraus JM, Speicher MR, Wang ZQ, Kestler HA, d'Adda di Fagagna F, Günes C, Rudolph KL

Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion.

EMBO J 2015; 1371-84. doi: 10.15252/embj.201490070

Conti A, Majorini MT, Elliott R, Ashworth A, Lord CJ, Cancelliere C, Bardelli A, Seneci P, Walczak H, Delia D, Lecis D

Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway.

Oncotarget 2015; 10994-1008. doi: 10.18632/oncotarget.3552

Masca NG, Hensor EM, Cornelius VR, Buffa FM, Marriott HM, Eales JM, Messenger MP, Anderson AE, Boot C, Bunce C, Goldin RD, Harris J, Hinchliffe RF, Junaid H, Kingston S, Martin-Ruiz C, Nelson CP, Peacock J, Seed PT, Shinkins B, Staples KJ, Toombs J, Wright AK, Teare MD

RIPOSTE: a framework for improving the design and analysis of laboratory-based research.

Elife 2015; . doi: 10.7554/eLife.05519

Arena S, Bellosillo B, Siravegna G, Martínez A, Cañadas I, Lazzari L, Ferruz N, Russo M, Misale S, González I, Iglesias M, Gavilan E, Corti G, Hobor S, Crisafulli G, Salido M, Sánchez J, Dalmases A, Bellmunt J, De Fabritiis G, Rovira A, Di Nicolantonio F, Albanell J, Bardelli A, Montagut C

Emergence of Multiple EGFR Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer.

Clin Cancer Res 2015; 2157-66. doi: 10.1158/1078-0432.CCR-14-2821

Farra R, Dapas B, Baiz D, Tonon F, Chiaretti S, Del Sal G, Rustighi A, Elvassore N, Pozzato G, Grassi M, Grassi G

Impairment of the Pin1/E2F1 axis in the anti-proliferative effect of bortezomib in hepatocellular carcinoma cells.

Biochimie 2015; 85-95. doi: 10.1016/j.biochi.2015.02.015

Vermezovic J, Adamowicz M, Santarpia L, Rustighi A, Forcato M, Lucano C, Massimiliano L, Costanzo V, Bicciato S, Del Sal G, d'Adda di Fagagna F

Notch is a direct negative regulator of the DNA-damage response.

Nat Struct Mol Biol 2015; 417-24. doi: 10.1038/nsmb.3013

Medico E, Russo M, Picco G, Cancelliere C, Valtorta E, Corti G, Buscarino M, Isella C, Lamba S, Martinoglio B, Veronese S, Siena S, Sartore-Bianchi A, Beccuti M, Mottolese M, Linnebacher M, Cordero F, Di Nicolantonio F, Bardelli A

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Nat Commun 2015; 7002. doi: 10.1038/ncomms8002

Kovatcheva M, Liu DD, Dickson MA, Klein ME, O'Connor R, Wilder FO, Socci ND, Tap WD, Schwartz GK, Singer S, Crago AM, Koff A

MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition.

Oncotarget 2015; 8226-43. doi: 10.18632/oncotarget.3364

Paneni F, Costantino S, Castello L, Battista R, Capretti G, Chiandotto S, D'Amario D, Scavone G, Villano A, Rustighi A, Crea F, Pitocco D, Lanza G, Volpe M, Del Sal G, Lüscher TF, Cosentino F

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes.

Eur Heart J 2015; 817-28. doi: 10.1093/eurheartj/ehu179

Grosso A, Pellegrini M, Cereda MG, Panico C, Staurenghi G, Sigler EJ

Pearls and pitfalls in diagnosis and management of coats disease.

Retina 2015; 614-23. doi: 10.1097/IAE.0000000000000485

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