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RESEARCH Giannino Del Sal Lab
Zucchelli S, Vilotti S, Calligaris R, Lavina ZS, Biagioli M, Foti R, De Maso L, Pinto M, Gorza M, Speretta E, Casseler C, Tell G, Del Sal G, Gustincich S

Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations.

Cell Death Differ 2009; 428-38. doi: 10.1038/cdd.2008.169

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Rustighi A, Tiberi L, Soldano A, Napoli M, Nuciforo P, Rosato A, Kaplan F, Capobianco A, Pece S, Di Fiore PP, Del Sal G

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer.

Nat Cell Biol 2009; 133-42. doi: 10.1038/ncb1822

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Gianni' M, Boldetti A, Guarnaccia V, Rambaldi A, Parrella E, Raska I, Rochette-Egly C, Del Sal G, Rustighi A, Terao M, Garattini E

Inhibition of the peptidyl-prolyl-isomerase Pin1 enhances the responses of acute myeloid leukemia cells to retinoic acid via stabilization of RARalpha and PML-RARalpha.

Cancer Res 2009; 1016-26. doi: 10.1158/0008-5472.CAN-08-2603

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Guida E, Bisso A, Fenollar-Ferrer C, Napoli M, Anselmi C, Girardini JE, Carloni P, Del Sal G

Peptide aptamers targeting mutant p53 induce apoptosis in tumor cells.

Cancer Res 2008; 6550-8. doi: 10.1158/0008-5472.CAN-08-0137

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Mauri F, McNamee LM, Lunardi A, Chiacchiera F, Del Sal G, Brodsky MH, Collavin L

Modification of Drosophila p53 by SUMO modulates its transactivation and pro-apoptotic functions.

J Biol Chem 2008; 20848-56. doi: 10.1074/jbc.M710186200

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Secchiero P, Corallini F, Rimondi E, Chiaruttini C, di Iasio MG, Rustighi A, Del Sal G, Zauli G

Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells.

Blood 2008; 1287-94. doi: 10.1182/blood-2007-05-092031

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Faniello MC, Di Sanzo M, Quaresima B, Baudi F, Di Caro V, Cuda G, Morrone G, Del Sal G, Spinelli G, Venuta S, Costanzo F

p53-mediated downregulation of H ferritin promoter transcriptional efficiency via NF-Y.

Int J Biochem Cell Biol 2008; 2110-9. doi: 10.1016/j.biocel.2008.02.010

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Mantovani F, Tocco F, Girardini J, Smith P, Gasco M, Lu X, Crook T, Del Sal G

The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP.

Nat Struct Mol Biol 2007; 912-20. doi: 10.1038/nsmb1306

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De Nicola F, Bruno T, Iezzi S, Di Padova M, Floridi A, Passananti C, Del Sal G, Fanciulli M

The prolyl isomerase Pin1 affects Che-1 stability in response to apoptotic DNA damage.

J Biol Chem 2007; 19685-91. doi: 10.1074/jbc.M610282200

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Zita MM, Marchionni I, Bottos E, Righi M, Del Sal G, Cherubini E, Zacchi P

Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function.

EMBO J 2007; 1761-71. doi: 10.1038/sj.emboj.7601625

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Pinton P, Rimessi A, Marchi S, Orsini F, Migliaccio E, Giorgio M, Contursi C, Minucci S, Mantovani F, Wieckowski MR, Del Sal G, Pelicci PG, Rizzuto R

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc.

Science 2007; 659-63. doi: 10.1126/science.1135380

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Bergamaschi D, Samuels Y, Sullivan A, Zvelebil M, Breyssens H, Bisso A, Del Sal G, Syed N, Smith P, Gasco M, Crook T, Lu X

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.

Nat Genet 2006; 1133-41. doi: 10.1038/ng1879

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Braithwaite AW, Del Sal G, Lu X

Some p53-binding proteins that can function as arbiters of life and death.

Cell Death Differ 2006; 984-93. doi: 10.1038/sj.cdd.4401924

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Gresko E, Roscic A, Ritterhoff S, Vichalkovski A, del Sal G, Schmitz ML

Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2.

EMBO J 2006; 1883-94. doi: 10.1038/sj.emboj.7601077

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Gueven N, Becherel OJ, Birrell G, Chen P, DelSal G, Carney JP, Grattan-Smith P, Lavin MF

Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.

Cancer Res 2006; 2907-12. doi: 10.1158/0008-5472.CAN-05-3428

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Frasca F, Rustighi A, Malaguarnera R, Altamura S, Vigneri P, Del Sal G, Giancotti V, Pezzino V, Vigneri R, Manfioletti G

HMGA1 inhibits the function of p53 family members in thyroid cancer cells.

Cancer Res 2006; 2980-9. doi: 10.1158/0008-5472.CAN-05-2637

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Berger M, Stahl N, Del Sal G, Haupt Y

Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage.

Mol Cell Biol 2005; 5380-8. doi: 10.1128/MCB.25.13.5380-5388.2005

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Strano S, Monti O, Pediconi N, Baccarini A, Fontemaggi G, Lapi E, Mantovani F, Damalas A, Citro G, Sacchi A, Del Sal G, Levrero M, Blandino G

The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage.

Mol Cell 2005; 447-59. doi: 10.1016/j.molcel.2005.04.008

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Imbriano C, Gurtner A, Cocchiarella F, Di Agostino S, Basile V, Gostissa M, Dobbelstein M, Del Sal G, Piaggio G, Mantovani R

Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.

Mol Cell Biol 2005; 3737-51. doi: 10.1128/MCB.25.9.3737-3751.2005

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Gostissa M, Morelli M, Mantovani F, Guida E, Piazza S, Collavin L, Brancolini C, Schneider C, Del Sal G

The transcriptional repressor hDaxx potentiates p53-dependent apoptosis.

J Biol Chem 2004; 48013-23. doi: 10.1074/jbc.M310801200

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Mantovani F, Gostissa M, Collavin L, Del Sal G

KeePin' the p53 family in good shape.

Cell Cycle 2004; 905-11.

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Collavin L, Gostissa M, Avolio F, Secco P, Ronchi A, Santoro C, Del Sal G

Modification of the erythroid transcription factor GATA-1 by SUMO-1.

Proc Natl Acad Sci U S A 2004; 8870-5. doi: 10.1073/pnas.0308605101

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Mantovani F, Piazza S, Gostissa M, Strano S, Zacchi P, Mantovani R, Blandino G, Del Sal G

Pin1 links the activities of c-Abl and p300 in regulating p73 function.

Mol Cell 2004; 625-36. doi: 10.1016/j.molcel.2004.05.007

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Paroni G, Mizzau M, Henderson C, Del Sal G, Schneider C, Brancolini C

Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis.

Mol Biol Cell 2004; 2804-18. doi: 10.1091/mbc.e03-08-0624

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Monte M, Benetti R, Collavin L, Marchionni L, Del Sal G, Schneider C

hGTSE-1 expression stimulates cytoplasmic localization of p53.

J Biol Chem 2004; 11744-52. doi: 10.1074/jbc.M311123200

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Tessari MA, Gostissa M, Altamura S, Sgarra R, Rustighi A, Salvagno C, Caretti G, Imbriano C, Mantovani R, Del Sal G, Giancotti V, Manfioletti G

Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2.

Mol Cell Biol 2003; 9104-16. doi: 10.1128/MCB.23.24.9104-9116.2003

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Tullo A, Mastropasqua G, Bourdon JC, Centonze P, Gostissa M, Costanzo A, Levrero M, Del Sal G, Saccone C, Sbisà E

Adenosine deaminase, a key enzyme in DNA precursors control, is a new p73 target.

Oncogene 2003; 8738-48. doi: 10.1038/sj.onc.1206967

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Monte M, Benetti R, Buscemi G, Sandy P, Del Sal G, Schneider C

The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function.

J Biol Chem 2003; 30356-64. doi: 10.1074/jbc.M302902200

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Gostissa M, Hofmann TG, Will H, Del Sal G

Regulation of p53 functions: let's meet at the nuclear bodies.

Curr Opin Cell Biol 2003; 351-7. doi: 10.1016/s0955-0674(03)00038-3

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Dahle Ø, Andersen TØ, Nordgård O, Matre V, Del Sal G, Gabrielsen OS

Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner.

Eur J Biochem 2003; 1338-48. doi: 10.1046/j.1432-1033.2003.03504.x

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Zacchi P, Gostissa M, Uchida T, Salvagno C, Avolio F, Volinia S, Ronai Z, Blandino G, Schneider C, Del Sal G

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults.

Nature 2002; 853-7. doi: 10.1038/nature01120

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Strano S, Fontemaggi G, Costanzo A, Rizzo MG, Monti O, Baccarini A, Del Sal G, Levrero M, Sacchi A, Oren M, Blandino G

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

J Biol Chem 2002; 18817-26. doi: 10.1074/jbc.M201405200

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D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S, Gostissa M, Coen S, Marchetti A, Del Sal G, Piaggio G, Fanciulli M, Appella E, Soddu S

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

Nat Cell Biol 2002; 11-9. doi: 10.1038/ncb714

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Benetti R, Del Sal G, Monte M, Paroni G, Brancolini C, Schneider C

The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis.

EMBO J 2001; 2702-14. doi: 10.1093/emboj/20.11.2702

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Fogal V, Gostissa M, Sandy P, Zacchi P, Sternsdorf T, Jensen K, Pandolfi PP, Will H, Schneider C, Del Sal G

Regulation of p53 activity in nuclear bodies by a specific PML isoform.

EMBO J 2000; 6185-95. doi: 10.1093/emboj/19.22.6185

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Stebel M, Vatta P, Ruaro ME, Del Sal G, Parton RG, Schneider C

The growth suppressing gas1 product is a GPI-linked protein.

FEBS Lett 2000; 152-8. doi: 10.1016/s0014-5793(00)02004-4

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Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ, Schneider C, Del Sal G

p53 is involved in the p120E4F-mediated growth arrest.

Oncogene 2000; 188-99. doi: 10.1038/sj.onc.1203250

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Gostissa M, Hengstermann A, Fogal V, Sandy P, Schwarz SE, Scheffner M, Del Sal G

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

EMBO J 1999; 6462-71. doi: 10.1093/emboj/18.22.6462

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Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G

Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids.

Cytogenet Cell Genet 1998; 99-100. doi: 10.1159/000015075

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Ruaro EM, Collavin L, Del Sal G, Haffner R, Oren M, Levine AJ, Schneider C

A proline-rich motif in p53 is required for transactivation-independent growth arrest as induced by Gas1.

Proc Natl Acad Sci U S A 1997; 4675-80. doi: 10.1073/pnas.94.9.4675

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Del Sal G, Murphy M, Ruaro E, Lazarevic D, Levine AJ, Schneider C

Cyclin D1 and p21/waf1 are both involved in p53 growth suppression.

Oncogene 1996; 177-85.

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DelSal G, Loda M, Pagano M

Cell cycle and cancer: critical events at the G1 restriction point.

Crit Rev Oncog 1996; 127-42. doi: 10.1615/critrevoncog.v7.i1-2.80

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Del Sal G, Ruaro EM, Utrera R, Cole CN, Levine AJ, Schneider C

Gas1-induced growth suppression requires a transactivation-independent p53 function.

Mol Cell Biol 1995; 7152-60. doi: 10.1128/MCB.15.12.7152

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Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, Chau V, Yew PR, Draetta GF, Rolfe M

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27.

Science 1995; 682-5. doi: 10.1126/science.7624798

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Del Sal G, Collavin L, Ruaro ME, Edomi P, Saccone S, Valle GD, Schneider C

Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene.

Proc Natl Acad Sci U S A 1994; 1848-52. doi: 10.1073/pnas.91.5.1848

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Del Sal G, Manfioletti G, Gustincich S, Ruaro E, Schneider C

New lambda and plasmid vectors for expression cloning in mammalian cells.

Biotechniques 1994; 134-8.

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Zanetti M, Del Sal G, Storici P, Schneider C, Romeo D

The cDNA of the neutrophil antibiotic Bac5 predicts a pro-sequence homologous to a cysteine proteinase inhibitor that is common to other neutrophil antibiotics.

J Biol Chem 1993; 522-6.

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Storici P, Del Sal G, Schneider C, Zanetti M

cDNA sequence analysis of an antibiotic dodecapeptide from neutrophils.

FEBS Lett 1992; 187-90. doi: 10.1016/0014-5793(92)80971-i

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Del Sal G, Storici P, Schneider C, Romeo D, Zanetti M

cDNA cloning of the neutrophil bactericidal peptide indolicidin.

Biochem Biophys Res Commun 1992; 467-72. doi: 10.1016/s0006-291x(05)81517-7

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Del Sal G, Ruaro ME, Philipson L, Schneider C

The growth arrest-specific gene, gas1, is involved in growth suppression.

Cell 1992; 595-607. doi: 10.1016/0092-8674(92)90429-g

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