Giuli MV, Mancusi A, Natiello B, Di Cristofano S, Reali R, Pignataro MG, D'Andrea D, Di Magno L, Nicoletti C, Giorgi A, Macone A, Camerini S, Casella M, Peruzzi G, Zema S, Canettieri G, Tomao F, Palaia I, Pernazza A, Rustighi A, Palermo R, Raimondo D, Monti A, Doti N, d'Amati G, Del Sal G, Screpanti I, Talora C, Bellavia D, Checquolo S

Prolyl-isomerase Pin1 drives platinum resistance by regulating Notch3 stability and function in ovarian cancer.

J Exp Clin Cancer Res 2026; . doi: 10.1186/s13046-026-03658-x

Arnoult C, Attardi LD, Batsheva K, Blandino G, Burns KH, Del Sal G, Kirsch DG, Lane DP, Levine AJ, Lozano G, Malkin D, Melino G, Oren M, Prives C, Schramek D

The legacy of a gentleman scientist: Pierre Hainaut.

Cell Death Differ 2026; 1-2. doi: 10.1038/s41418-025-01586-5

Laue K, Pozzi S, Zerbib J, Bertolio R, Eliezer Y, Cohen-Sharir Y, Winkler T, Caputo M, Ricci AA, Adler L, Khoury R, Longobardi G, Slutsky R, Leikin-Frenkel AI, Ovadia S, Lange K, Rustighi A, Piazza S, Sacconi A, Magesh RY, Keller FN, Berthelet J, Schäffer A, Saad R, Israeli Dangoor S, Szczepanowska K, Barshack I, Liao Y, Malitsky S, Brandis A, Broggini T, Czabanka M, Shi W, Merino D, Watson EV, Blandino G, Erez A, Ashery-Padan R, Medyouf H, Bertero L, Del Sal G, Satchi-Fainaro R, Ben-David U

p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism.

Nat Genet 2026; 116-131. doi: 10.1038/s41588-025-02446-1

Anfuso B, Velnati S, Selvestrel D, Garlant C, Ferracci E, Baj G, Parisse P, Overi D, Bertolio R, Bulla R, Sonzogni A, Bramuzzo M, Casalis L, Cocomello N, Baratta F, Del Ben M, Giraudi P, Tiribelli C, Rosso N, Mastronardi M, Tarchi P, Pinamonti M, Zanconati F, de Manzini N, Gaudio E, Palmisano S, Bonazza D, Del Sal G, Carpino G, Chiacchiera F, Sorrentino G

An organotypic model of ductular reaction reveals a mevalonate-dependent vulnerability in reactive biliary cells.

Cell Rep 2025; 116681. doi: 10.1016/j.celrep.2025.116681

Bertolazzi G, Cancila V, Vacca D, Belmonte B, Lecis D, Moghaddam PS, Di Napoli A, Colombo MP, Pruneri G, Del Sal G, Scita G, Fassan M, Vecchione A, Bicciato S, Tripodo C

Extraction of a stromal metastatic gene signature in breast cancer via spatial profiling.

J Exp Clin Cancer Res 2025; 89. doi: 10.1186/s13046-025-03353-3

Popęda M, Kowalski K, Wenta T, Beznoussenko GV, Rychłowski M, Mironov A, Lavagnino Z, Barozzi S, Richert J, Bertolio R, Myszczyński K, Szade J, Bieńkowski M, Miszewski K, Matuszewski M, Żaczek AJ, Braga L, Del Sal G, Bednarz-Knoll N, Maiuri P, Nastały P

Emerin mislocalization during chromatin bridge resolution can drive prostate cancer cell invasiveness in a collagen-rich microenvironment.

Exp Mol Med 2024; 2016-2032. doi: 10.1038/s12276-024-01308-w

Choi HY, Zhu Y, Zhao X, Mehta S, Hernandez JC, Lee JJ, Kou Y, Machida R, Giacca M, Del Sal G, Ray R, Eoh H, Tahara SM, Chen L, Tsukamoto H, Machida K

NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells.

Exp Mol Med 2024; 461-477. doi: 10.1038/s12276-024-01174-6

Cappelletto A, Alfì E, Volf N, Vu TVA, Bortolotti F, Ciucci G, Vodret S, Fantuz M, Perin M, Colliva A, Rozzi G, Rossi M, Ruozi G, Zentilin L, Vuerich R, Borin D, Lapasin R, Piazza S, Chiesa M, Lorizio D, Triboli L, Kumar S, Morello G, Tripodo C, Pinamonti M, Piperno GM, Benvenuti F, Rustighi A, Jo H, Piccolo S, Del Sal G, Carrer A, Giacca M, Zacchigna S

EMID2 is a novel biotherapeutic for aggressive cancers identified by in vivo screening.

J Exp Clin Cancer Res 2024; 15. doi: 10.1186/s13046-023-02942-4

Morosi LG, Piperno GM, López L, Amadio R, Joshi S, Rustighi A, Del Sal G, Benvenuti F

ALCAM-mediated cDC1 CD8 T cells interactions are suppressed in advanced lung tumors.

Oncoimmunology 2024; 2367843. doi: 10.1080/2162402X.2024.2367843

Tombari C, Zannini A, Bertolio R, Pedretti S, Audano M, Triboli L, Cancila V, Vacca D, Caputo M, Donzelli S, Segatto I, Vodret S, Piazza S, Rustighi A, Mantovani F, Belletti B, Baldassarre G, Blandino G, Tripodo C, Bicciato S, Mitro N, Del Sal G

Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth.

Nat Commun 2023; 6777. doi: 10.1038/s41467-023-42458-1

Apollonio M, Bellazzo A, Franco N, Lombardi S, Senigagliesi B, Casalis L, Parisse P, Thalhammer A, Baj G, De Florian Fania R, Del Sal G, Collavin L

The Tumor Suppressor DAB2IP Is Regulated by Cell Contact and Contributes to YAP/TAZ Inhibition in Confluent Cells.

Cancers (Basel) 2023; . doi: 10.3390/cancers15133379

Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, Bano D, Barlev NA, Bartek J, Bazan NG, Becker C, Bernassola F, Bertrand MJM, Bianchi ME, Blagosklonny MV, Blander JM, Blandino G, Blomgren K, Borner C, Bortner CD, Bove P, Boya P, Brenner C, Broz P, Brunner T, Damgaard RB, Calin GA, Campanella M, Candi E, Carbone M, Carmona-Gutierrez D, Cecconi F, Chan FK, Chen GQ, Chen Q, Chen YH, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Ciliberto G, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Daugaard M, Dawson TM, Dawson VL, De Maria R, De Strooper B, Debatin KM, Deberardinis RJ, Degterev A, Del Sal G, Deshmukh M, Di Virgilio F, Diederich M, Dixon SJ, Dynlacht BD, El-Deiry WS, Elrod JW, Engeland K, Fimia GM, Galassi C, Ganini C, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Gerlic M, Ghosh S, Green DR, Greene LA, Gronemeyer H, Häcker G, Hajnóczky G, Hardwick JM, Haupt Y, He S, Heery DM, Hengartner MO, Hetz C, Hildeman DA, Ichijo H, Inoue S, Jäättelä M, Janic A, Joseph B, Jost PJ, Kanneganti TD, Karin M, Kashkar H, Kaufmann T, Kelly GL, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Kluck R, Krysko DV, Kulms D, Kumar S, Lavandero S, Lavrik IN, Lemasters JJ, Liccardi G, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Luedde T, MacFarlane M, Madeo F, Malorni W, Manic G, Mantovani R, Marchi S, Marine JC, Martin SJ, Martinou JC, Mastroberardino PG, Medema JP, Mehlen P, Meier P, Melino G, Melino S, Miao EA, Moll UM, Muñoz-Pinedo C, Murphy DJ, Niklison-Chirou MV, Novelli F, Núñez G, Oberst A, Ofengeim D, Opferman JT, Oren M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pentimalli F, Pereira DM, Pervaiz S, Peter ME, Pinton P, Porta G, Prehn JHM, Puthalakath H, Rabinovich GA, Rajalingam K, Ravichandran KS, Rehm M, Ricci JE, Rizzuto R, Robinson N, Rodrigues CMP, Rotblat B, Rothlin CV, Rubinsztein DC, Rudel T, Rufini A, Ryan KM, Sarosiek KA, Sawa A, Sayan E, Schroder K, Scorrano L, Sesti F, Shao F, Shi Y, Sica GS, Silke J, Simon HU, Sistigu A, Stephanou A, Stockwell BR, Strapazzon F, Strasser A, Sun L, Sun E, Sun Q, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Troy CM, Turk B, Urbano N, Vandenabeele P, Vanden Berghe T, Vander Heiden MG, Vanderluit JL, Verkhratsky A, Villunger A, von Karstedt S, Voss AK, Vousden KH, Vucic D, Vuri D, Wagner EF, Walczak H, Wallach D, Wang R, Wang Y, Weber A, Wood W, Yamazaki T, Yang HT, Zakeri Z, Zawacka-Pankau JE, Zhang L, Zhang H, Zhivotovsky B, Zhou W, Piacentini M, Kroemer G, Galluzzi L

Apoptotic cell death in disease-Current understanding of the NCCD 2023.

Cell Death Differ 2023; 1097-1154. doi: 10.1038/s41418-023-01153-w

Lorenzoni M, De Felice D, Beccaceci G, Di Donato G, Foletto V, Genovesi S, Bertossi A, Cambuli F, Lorenzin F, Savino A, Avalle L, Cimadamore A, Montironi R, Weber V, Carbone FG, Barbareschi M, Demichelis F, Romanel A, Poli V, Del Sal G, Julio MK, Gaspari M, Alaimo A, Lunardi A

ETS-related gene (ERG) undermines genome stability in mouse prostate progenitors via Gsk3β dependent Nkx3.1 degradation.

Cancer Lett 2022; 215612. doi: 10.1016/j.canlet.2022.215612

Buemi V, Schillaci O, Santorsola M, Bonazza D, Broccia PV, Zappone A, Bottin C, Dell'Omo G, Kengne S, Cacchione S, Raffa GD, Piazza S, di Fagagna FD, Benetti R, Cortale M, Zanconati F, Del Sal G, Schoeftner S

TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance.

Nat Commun 2022; 2302. doi: 10.1038/s41467-022-29907-z

Napoletano F, Ferrari Bravo G, Voto IAP, Santin A, Celora L, Campaner E, Dezi C, Bertossi A, Valentino E, Santorsola M, Rustighi A, Fajner V, Maspero E, Ansaloni F, Cancila V, Valenti CF, Santo M, Artimagnella OB, Finaurini S, Gioia U, Polo S, Sanges R, Tripodo C, Mallamaci A, Gustincich S, d'Adda di Fagagna F, Mantovani F, Specchia V, Del Sal G

The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.

Cell Rep 2021; 109694. doi: 10.1016/j.celrep.2021.109694

De Santis F, Fucà G, Schadendorf D, Mantovani A, Magnani L, Lisanti M, Pettitt S, Bellone M, Del Sal G, Minucci S, Eggermont A, Bruzzi P, Bicciato S, Conte P, Noberini R, Hiscott J, De Braud F, Del Vecchio M, Di Nicola M

Anticancer innovative therapy congress: Highlights from the 10th anniversary edition.

Cytokine Growth Factor Rev 2021; 1-8. doi: 10.1016/j.cytogfr.2021.02.001

Campaner E, Zannini A, Santorsola M, Bonazza D, Bottin C, Cancila V, Tripodo C, Bortul M, Zanconati F, Schoeftner S, Del Sal G

Breast Cancer Organoids Model Patient-Specific Response to Drug Treatment.

Cancers (Basel) 2020; . doi: 10.3390/cancers12123869

Capaci V, Bascetta L, Fantuz M, Beznoussenko GV, Sommaggio R, Cancila V, Bisso A, Campaner E, Mironov AA, Wiśniewski JR, Ulloa Severino L, Scaini D, Bossi F, Lees J, Alon N, Brunga L, Malkin D, Piazza S, Collavin L, Rosato A, Bicciato S, Tripodo C, Mantovani F, Del Sal G

Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome.

Nat Commun 2020; 3945. doi: 10.1038/s41467-020-17596-5

Vivenza D, Garrone O, Brizio R, Mantovani F, Del Sal G, Merlano M, Crook T, Lo Nigro C

Expression and subcellular localization of the bromodomain-containing protein 7 is a prognostic biomarker in breast cancer.

Anticancer Drugs 2020; 423-430. doi: 10.1097/CAD.0000000000000897

Sicari D, Fantuz M, Bellazzo A, Valentino E, Apollonio M, Pontisso I, Di Cristino F, Dal Ferro M, Bicciato S, Del Sal G, Collavin L

Mutant p53 improves cancer cells' resistance to endoplasmic reticulum stress by sustaining activation of the UPR regulator ATF6.

Oncogene 2019; 6184-6195. doi: 10.1038/s41388-019-0878-3

Rehman M, Vodret S, Braga L, Guarnaccia C, Celsi F, Rossetti G, Martinelli V, Battini T, Long C, Vukusic K, Kocijan T, Collesi C, Ring N, Skoko N, Giacca M, Del Sal G, Confalonieri M, Raspa M, Marcello A, Myers MP, Crovella S, Carloni P, Zacchigna S

High-throughput screening discovers antifibrotic properties of haloperidol by hindering myofibroblast activation.

JCI Insight 2019; . doi: 10.1172/jci.insight.123987

Borini Etichetti C, Di Benedetto C, Rossi C, Baglioni MV, Bicciato S, Del Sal G, Menacho-Marquez M, Girardini J

Isoprenylcysteine carboxy methyltransferase (ICMT) is associated with tumor aggressiveness and its expression is controlled by the p53 tumor suppressor.

J Biol Chem 2019; 5060-5073. doi: 10.1074/jbc.RA118.006037

Bertolio R, Napoletano F, Mano M, Maurer-Stroh S, Fantuz M, Zannini A, Bicciato S, Sorrentino G, Del Sal G

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism.

Nat Commun 2019; 1326. doi: 10.1038/s41467-019-09152-7

Mantovani F, Collavin L, Del Sal G

Mutant p53 as a guardian of the cancer cell.

Cell Death Differ 2019; 199-212. doi: 10.1038/s41418-018-0246-9

Zannini A, Rustighi A, Campaner E, Del Sal G

Oncogenic Hijacking of the PIN1 Signaling Network.

Front Oncol 2019; 94. doi: 10.3389/fonc.2019.00094

Caroli J, Sorrentino G, Forcato M, Del Sal G, Bicciato S

GDA, a web-based tool for Genomics and Drugs integrated analysis.

Nucleic Acids Res 2018; W148-W156. doi: 10.1093/nar/gky434

Bellazzo A, Di Minin G, Valentino E, Sicari D, Torre D, Marchionni L, Serpi F, Stadler MB, Taverna D, Zuccolotto G, Montagner IM, Rosato A, Tonon F, Zennaro C, Agostinis C, Bulla R, Mano M, Del Sal G, Collavin L

Cell-autonomous and cell non-autonomous downregulation of tumor suppressor DAB2IP by microRNA-149-3p promotes aggressiveness of cancer cells.

Cell Death Differ 2018; 1224-1238. doi: 10.1038/s41418-018-0088-5

Pop-Bica C, Pintea S, Cojocneanu-Petric R, Del Sal G, Piazza S, Wu ZH, Alencar AJ, Lossos IS, Berindan-Neagoe I, Calin GA

MiR-181 family-specific behavior in different cancers: a meta-analysis view.

Cancer Metastasis Rev 2018; 17-32. doi: 10.1007/s10555-017-9714-9

Sorrentino G, Mantovani F, Del Sal G

The stiff RhoAd from mevalonate to mutant p53.

Cell Death Differ 2018; 645-647. doi: 10.1038/s41418-018-0091-x

Ingallina E, Sorrentino G, Bertolio R, Lisek K, Zannini A, Azzolin L, Severino LU, Scaini D, Mano M, Mantovani F, Rosato A, Bicciato S, Piccolo S, Del Sal G

Mechanical cues control mutant p53 stability through a mevalonate-RhoA axis.

Nat Cell Biol 2018; 28-35. doi: 10.1038/s41556-017-0009-8

Bellazzo A, Sicari D, Valentino E, Del Sal G, Collavin L

Complexes formed by mutant p53 and their roles in breast cancer.

Breast Cancer (Dove Med Press) 2018; 101-112. doi: 10.2147/BCTT.S145826

Tan MH, Li Q, Shanmugam R, Piskol R, Kohler J, Young AN, Liu KI, Zhang R, Ramaswami G, Ariyoshi K, Gupte A, Keegan LP, George CX, Ramu A, Huang N, Pollina EA, Leeman DS, Rustighi A, Goh YPS, Chawla A, Del Sal G, Peltz G, Brunet A, Conrad DF, Samuel CE, O'Connell MA, Walkley CR, Nishikura K, Li JB

Dynamic landscape and regulation of RNA editing in mammals.

Nature 2017; 249-254. doi: 10.1038/nature24041

Noto A, De Vitis C, Pisanu ME, Roscilli G, Ricci G, Catizone A, Sorrentino G, Chianese G, Taglialatela-Scafati O, Trisciuoglio D, Del Bufalo D, Di Martile M, Di Napoli A, Ruco L, Costantini S, Jakopin Z, Budillon A, Melino G, Del Sal G, Ciliberto G, Mancini R

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ.

Oncogene 2017; 4573-4584. doi: 10.1038/onc.2017.75

Noto A, De Vitis C, Pisanu ME, Roscilli G, Ricci G, Catizone A, Sorrentino G, Chianese G, Taglialatela-Scafati O, Trisciuoglio D, Del Bufalo D, Di Martile M, Di Napoli A, Ruco L, Costantini S, Jakopin Z, Budillon A, Melino G, Del Sal G, Ciliberto G, Mancini R

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ.

Oncogene 2017; 4671-4672. doi: 10.1038/onc.2017.212

Valentino E, Bellazzo A, Di Minin G, Sicari D, Apollonio M, Scognamiglio G, Di Bonito M, Botti G, Del Sal G, Collavin L

Mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB2IP.

Proc Natl Acad Sci U S A 2017; 7623-7628. doi: 10.1073/pnas.1700996114

Campaner E, Rustighi A, Zannini A, Cristiani A, Piazza S, Ciani Y, Kalid O, Golan G, Baloglu E, Shacham S, Valsasina B, Cucchi U, Pippione AC, Lolli ML, Giabbai B, Storici P, Carloni P, Rossetti G, Benvenuti F, Bello E, D'Incalci M, Cappuzzello E, Rosato A, Del Sal G

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action.

Nat Commun 2017; 15772. doi: 10.1038/ncomms15772

Rustighi A, Zannini A, Campaner E, Ciani Y, Piazza S, Del Sal G

PIN1 in breast development and cancer: a clinical perspective.

Cell Death Differ 2017; 200-211. doi: 10.1038/cdd.2016.122

Sorrentino G, Ruggeri N, Zannini A, Ingallina E, Bertolio R, Marotta C, Neri C, Cappuzzello E, Forcato M, Rosato A, Mano M, Bicciato S, Del Sal G

Glucocorticoid receptor signalling activates YAP in breast cancer.

Nat Commun 2017; 14073. doi: 10.1038/ncomms14073

Lo Sardo F, Forcato M, Sacconi A, Capaci V, Zanconato F, Di Agostino S, Del Sal G, Pandolfi PP, Strano S, Bicciato S, Blandino G

MCM7 and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer.

Carcinogenesis 2017; 64-75. doi: 10.1093/carcin/bgw110

Ibarra MS, Borini Etichetti C, Di Benedetto C, Rosano GL, Margarit E, Del Sal G, Mione M, Girardini J

Dynamic regulation of Pin1 expression and function during zebrafish development.

PLoS One 2017; e0175939. doi: 10.1371/journal.pone.0175939

Tosi A, Dalla Santa S, Cappuzzello E, Marotta C, Walerych D, Del Sal G, Zanovello P, Sommaggio R, Rosato A

Identification of a HLA-A*0201-restricted immunogenic epitope from the universal tumor antigen DEPDC1.

Oncoimmunology 2017; e1313371. doi: 10.1080/2162402X.2017.1313371

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