Cancer research from different perspectives
IFOM studies the mechanisms that transform a normal cell into a tumor cell through an interdisciplinary approach that integrates biology, medicine, bioinformatics, physics, engineering, and mathematics. Since 2000, over 50 research groups have explored the frontiers of molecular oncology, which are led today by 28 directors whose work is integrated and complementary.
Cell Plasticity, Aging, and Tumor Evolution
Mechanisms of Tumor Cell Migration | Giorgio Scita
We study how mechanical stress and tissue fluidification govern the earliest steps of tumor evolution, enabling collective migration and early dissemination. We uncover how mechanical forces trigger nuclear and mitochondrial DNA release, activating innate immunity and shaping tumor–immune interactions.