Mechanisms of Tumor Cell Migration
Research area

Mechanisms of Tumor Cell Migration

We study how mechanical stress and tissue fluidification govern the earliest steps of tumor evolution, enabling collective migration and early dissemination. We uncover how mechanical forces trigger nuclear and mitochondrial DNA release, activating innate immunity and shaping tumor–immune interactions.

scita
Researcher

Giorgio Scita

Giorgio Scita graduated in Biology and specialized in Food Chemistry and Technology at the University of Parma. He pursued his postdoctoral training at the University of California, Berkeley, and at the National Cancer Institute (NCI) of the National Institutes of Health (NIH).


In 1995, he joined the European Institute of Oncology (IEO) in Milan, and since 2001, he has been a Principal Investigator at IFOM ETS – The AIRC Institute of Molecular Oncology. Since 2006, he has served as Professor of General Pathology at the Faculty of Medicine and Surgery of the University of Milan. He has been an EMBO member since 2014 and was awarded an ERC Advanced Grant in 2012 and an ERC Synergy Grant in 2022.

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Publications
Marchesi S, Guidolin C, Massey AE, Lemahieu G, Lavagnino Z, Beznoussenko GV, Mironov AA, Green BJ, Allievi E, Martini E, Magni S, Ghisleni A, Lomazzi C, Benvenuto AF, Schertel A, van Faassen DA, Freddi S, Bertalot G, Parazzoli D, Maiuri P, Mapelli M, Pece S, Sigismund S, Gauthier NC, Cavalcanti-Adam EA, Cartagena-Rivera AX, Giavazzi F, Scita G, Disanza A

Mechanisms of active wetting and fluidification in epithelial cell collectives.

Nat Mater 2026; . doi: 10.1038/s41563-026-02553-2

Fusilier Z, Clément A, Simon F, Calvente I, Jean-Marie R, Mathieu M, Calmettes V, Piastra-Facon F, Quintana-Perez Y, Clement JG, Crestey L, Lumineau E, Henninger R, Tonani M, Manriquez V, Lacerda Mariano L, Bensaid L, de Villemagne P, Piaggio E, Semetey V, Coscoy S, Martini E, Scita G, Gelly JC, Ivaska J, Isambert H, Goudot C, Pierobon P, Lennon-Duménil AM, Moreau HD

Macrophages restrict tumor immune infiltration by controlling collagen topography.

Sci Immunol 2026; eadw8291. doi: 10.1126/sciimmunol.adw8291

Kaivola J, Punovuori K, Chastney MR, Abdo H, Follain G, Mathieu M, Joshi O, Miroshnikova YA, Krautgasser F, Di Franco J, Conway JRW, Held S, Bertillot F, Hagström J, Mäkitie A, Irjala H, Ventelä S, Hamidi H, Scita G, Cerbino R, Wickström SA, Ivaska J

Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties.

Nat Mater 2026; . doi: 10.1038/s41563-025-02473-7

Makkieh M, Passeri AA, Lazzari D, Marchesi S, Disanza A, Salem RKA, Bonacci F, Mazzella C, Martini E, Tonani M, Donati L, Bellini E, Abdo H, Pineau J, Magni S, Orsenigo F, Piel M, Fioretto D, Martino S, Mattarelli M, Scita G, Green BJ, Caponi S

Brillouin Microscopy of Breast tumor Spheroids On-a-Chip: Mechanical and Transcriptional Responses to Microfluidic-Induced Rapid Deformations.

Adv Sci (Weinh) 2026; e13153. doi: 10.1002/advs.202513153

Abdo H, Barzaghi L, Shen Y, Bellini E, Martini E, Magni S, Barozzi S, Orsenigo F, Parazzoli D, Beznoussenko GV, Franco JD, Krautgasser F, Kaivola J, Cinquanta M, Lazzarin A, Sigismund S, Ivaska J, Cerbino R, Scita G

De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems.

Adv Sci (Weinh) 2026; e08648. doi: 10.1002/advs.202508648

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