Il nostro contributo

L’impatto scientifico misura l’influenza e la rilevanza delle scoperte e delle pubblicazioni di un istituto di ricerca. Per IFOM, l’impatto scientifico non si limita solo alla quantità di pubblicazioni, ma si estende alla qualità delle riviste su cui vengono pubblicati i nostri studi, alla visibilità dei nostri risultati e alla capacità di trasformare queste scoperte in avanzamenti concreti nella lotta contro il cancro.

Di Cosimo S, La Rocca E, Ljevar S, De Santis MC, Bini M, Cappelletti V, Valenti M, Baili P, de Braud FG, Folli S, Scaperrotta G, Volpi C, Vingiani A, Vernieri C, Verderio P, Miceli R, Pruneri G

Moving HER2-low breast cancer predictive and prognostic data from clinical trials into the real world.

Front Mol Biosci 2022; 996434. doi: 10.3389/fmolb.2022.996434

Pusceddu S, Vernieri C, Di Maio M, Prinzi N, Torchio M, Corti F, Coppa J, Buzzoni R, Di Bartolomeo M, Milione M, Regnault B, Truong Thanh XM, Mazzaferro V, de Braud F

Impact of Diabetes and Metformin Use on Enteropancreatic Neuroendocrine Tumors: Post Hoc Analysis of the CLARINET Study.

Cancers (Basel) 2021; . doi: 10.3390/cancers14010069

Frayssinhes JA, Cerruti F, Laulin J, Cattaneo A, Bachi A, Apcher S, Coux O, Cascio P

PA28γ-20S proteasome is a proteolytic complex committed to degrade unfolded proteins.

Cell Mol Life Sci 2021; 45. doi: 10.1007/s00018-021-04045-9

Humphreys IR, Pei J, Baek M, Krishnakumar A, Anishchenko I, Ovchinnikov S, Zhang J, Ness TJ, Banjade S, Bagde SR, Stancheva VG, Li XH, Liu K, Zheng Z, Barrero DJ, Roy U, Kuper J, Fernández IS, Szakal B, Branzei D, Rizo J, Kisker C, Greene EC, Biggins S, Keeney S, Miller EA, Fromme JC, Hendrickson TL, Cong Q, Baker D

Computed structures of core eukaryotic protein complexes.

Science 2021; eabm4805. doi: 10.1126/science.abm4805

Wallis SS, Ventimiglia LN, Otigbah E, Infante E, Cuesta-Geijo MA, Kidiyoor GR, Carbajal MA, Fleck RA, Foiani M, Garcia-Manyes S, Martin-Serrano J, Agromayor M

The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair.

Dev Cell 2021; 3192-3202.e8. doi: 10.1016/j.devcel.2021.10.022

De Simone M, Chirichella M, Emming S, Mazzara S, Ranzani V, Gruarin P, Moschetti G, Pulvirenti N, Maglie S, Vasco C, Crosti MC, Rossetti G, Pagani M, Abrignani S, Monticelli S, Geginat J

Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R.

Eur J Immunol 2021; 3243-3246. doi: 10.1002/eji.202149315

Sáinz-Jaspeado M, Smith RO, Plunde O, Pawelzik SC, Jin Y, Nordling S, Ding Y, Aspenström P, Hedlund M, Bastianello G, Ascione F, Li Q, Demir CS, Fernando D, Daniel G, Franco-Cereceda A, Kroon J, Foiani M, Petrova TV, Kilimann MW, Bäck M, Claesson-Welsh L

Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium.

Circulation 2021; 1629-1645. doi: 10.1161/CIRCULATIONAHA.121.054182

Pavani M, Bonaiuti P, Chiroli E, Gross F, Natali F, Macaluso F, Póti Á, Pasqualato S, Farkas Z, Pompei S, Cosentino Lagomarsino M, Rancati G, Szüts D, Ciliberto A

Epistasis, aneuploidy, and functional mutations underlie evolution of resistance to induced microtubule depolymerization.

EMBO J 2021; e108225. doi: 10.15252/embj.2021108225

Vorselen D, Barger SR, Wang Y, Cai W, Theriot JA, Gauthier NC, Krendel M

Phagocytic 'teeth' and myosin-II 'jaw' power target constriction during phagocytosis.

Elife 2021; . doi: 10.7554/eLife.68627

Monzo P, Crestani M, Chong YK, Ghisleni A, Hennig K, Li Q, Kakogiannos N, Giannotta M, Richichi C, Dini T, Dejana E, Maiuri P, Balland M, Sheetz MP, Pelicci G, Ang BT, Tang C, Gauthier NC

Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion.

Dev Cell 2021; 2841-2855.e8. doi: 10.1016/j.devcel.2021.09.007

Van Beek JJP, Puccio S, Roberto A, De Paoli F, Graziano G, Salviato E, Alvisi G, Zanon V, Scarpa A, Zaghi E, Calvi M, Di Vito C, Mineri R, Sarina B, De Philippis C, Santoro A, Mariotti J, Bramanti S, Ferrari F, Castagna L, Mavilio D, Lugli E

Single-cell profiling reveals the dynamics of cytomegalovirus-specific T cells in haploidentical hematopoietic stem cell transplantation.

Haematologica 2021; 2768-2773. doi: 10.3324/haematol.2020.276352

Moreno-Layseca P, Jäntti NZ, Godbole R, Sommer C, Jacquemet G, Al-Akhrass H, Conway JRW, Kronqvist P, Kallionpää RE, Oliveira-Ferrer L, Cervero P, Linder S, Aepfelbacher M, Zauber H, Rae J, Parton RG, Disanza A, Scita G, Mayor S, Selbach M, Veltel S, Ivaska J

Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis.

Nat Cell Biol 2021; 1073-1084. doi: 10.1038/s41556-021-00767-x

Bampton A, Gatt A, Humphrey J, Cappelli S, Bhattacharya D, Foti S, Brown AL, Asi Y, Low YH, Foiani M, Raj T, Buratti E, Fratta P, Lashley T

HnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing.

Acta Neuropathol 2021; 609-627. doi: 10.1007/s00401-021-02340-0

Nader GPF, Agüera-Gonzalez S, Routet F, Gratia M, Maurin M, Cancila V, Cadart C, Palamidessi A, Ramos RN, San Roman M, Gentili M, Yamada A, Williart A, Lodillinsky C, Lagoutte E, Villard C, Viovy JL, Tripodo C, Galon J, Scita G, Manel N, Chavrier P, Piel M

Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion.

Cell 2021; 5230-5246.e22. doi: 10.1016/j.cell.2021.08.035

Ajazi A, Bruhn C, Shubassi G, Lucca C, Ferrari E, Cattaneo A, Bachi A, Manfrini N, Biffo S, Martini E, Minucci S, Vernieri C, Foiani M

Endosomal trafficking and DNA damage checkpoint kinases dictate survival to replication stress by regulating amino acid uptake and protein synthesis.

Dev Cell 2021; 2607-2622.e6. doi: 10.1016/j.devcel.2021.08.019

Fajner V, Giavazzi F, Sala S, Oldani A, Martini E, Napoletano F, Parazzoli D, Cesare G, Cerbino R, Maspero E, Vaccari T, Polo S

Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles.

Nat Commun 2021; 5488. doi: 10.1038/s41467-021-25809-8

Napoletano F, Ferrari Bravo G, Voto IAP, Santin A, Celora L, Campaner E, Dezi C, Bertossi A, Valentino E, Santorsola M, Rustighi A, Fajner V, Maspero E, Ansaloni F, Cancila V, Valenti CF, Santo M, Artimagnella OB, Finaurini S, Gioia U, Polo S, Sanges R, Tripodo C, Mallamaci A, Gustincich S, d'Adda di Fagagna F, Mantovani F, Specchia V, Del Sal G

The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.

Cell Rep 2021; 109694. doi: 10.1016/j.celrep.2021.109694

Sangaletti S, Ferrara R, Tripodo C, Garassino MC, Colombo MP

Myeloid cell heterogeneity in lung cancer: implication for immunotherapy.

Cancer Immunol Immunother 2021; 2429-2438. doi: 10.1007/s00262-021-02916-5

Valdemarin F, Caffa I, Persia A, Cremonini AL, Ferrando L, Tagliafico L, Tagliafico A, Guijarro A, Carbone F, Ministrini S, Bertolotto M, Becherini P, Bonfiglio T, Giannotti C, Khalifa A, Ghanem M, Cea M, Sucameli M, Murialdo R, Barbero V, Gradaschi R, Bruzzone F, Borgarelli C, Lambertini M, Vernieri C, Zoppoli G, Longo VD, Montecucco F, Sukkar SG, Nencioni A

Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment.

Cancers (Basel) 2021; . doi: 10.3390/cancers13164013

Ligorio F, Pellegrini I, Castagnoli L, Vingiani A, Lobefaro R, Zattarin E, Santamaria M, Pupa SM, Pruneri G, de Braud F, Vernieri C

Targeting lipid metabolism is an emerging strategy to enhance the efficacy of anti-HER2 therapies in HER2-positive breast cancer.

Cancer Lett 2021; 77-87. doi: 10.1016/j.canlet.2021.04.023

Germano G, Lu S, Rospo G, Lamba S, Rousseau B, Fanelli S, Stenech D, Le DT, Hays J, Totaro MG, Amodio V, Chilà R, Mondino A, Diaz LA, Di Nicolantonio F, Bardelli A

CD4 T Cell-Dependent Rejection of Beta-2 Microglobulin Null Mismatch Repair-Deficient Tumors.

Cancer Discov 2021; 1844-1859. doi: 10.1158/2159-8290.CD-20-0987

Mauri G, Durinikova E, Amatu A, Tosi F, Cassingena A, Rizzetto F, Buzo K, Arcella P, Aquilano MC, Bonoldi E, Marsoni S, Siena S, Bardelli A, Sartore-Bianchi A, Arena S

Empowering Clinical Decision Making in Oligometastatic Colorectal Cancer: The Potential Role of Drug Screening of Patient-Derived Organoids.

JCO Precis Oncol 2021; . doi: 10.1200/PO.21.00143

Ughetto S, Migliore C, Pietrantonio F, Apicella M, Petrelli A, D'Errico L, Durando S, Moya-Rull D, Bellomo SE, Rizzolio S, Capelôa T, Ribisi S, Degiuli M, Reddavid R, Rapa I, Fumagalli U, De Pascale S, Ribero D, Baronchelli C, Sgroi G, Rausa E, Baiocchi GL, Molfino S, Manenti S, Bencivenga M, Sacco M, Castelli C, Siena S, Sartore-Bianchi A, Tosi F, Morano F, Raimondi A, Prisciandaro M, Gloghini A, Marsoni S, Sottile A, Sarotto I, Sapino A, Marchiò C, Cassoni P, Guarrera S, Corso S, Giordano S

Personalized therapeutic strategies in HER2-driven gastric cancer.

Gastric Cancer 2021; 897-912. doi: 10.1007/s10120-021-01165-w

Morello G, Cancila V, La Rosa M, Germano G, Lecis D, Amodio V, Zanardi F, Iannelli F, Greco D, La Paglia L, Fiannaca A, Urso AM, Graziano G, Ferrari F, Pupa SM, Sangaletti S, Chiodoni C, Pruneri G, Bardelli A, Colombo MP, Tripodo C

T Cells Expressing Receptor Recombination/Revision Machinery Are Detected in the Tumor Microenvironment and Expanded in Genomically Over-unstable Models.

Cancer Immunol Res 2021; 825-837. doi: 10.1158/2326-6066.CIR-20-0645

Kosar M, Giannattasio M, Piccini D, Maya-Mendoza A, García-Benítez F, Bartkova J, Barroso SI, Gaillard H, Martini E, Restuccia U, Ramirez-Otero MA, Garre M, Verga E, Andújar-Sánchez M, Maynard S, Hodny Z, Costanzo V, Kumar A, Bachi A, Aguilera A, Bartek J, Foiani M

The human nucleoporin Tpr protects cells from RNA-mediated replication stress.

Nat Commun 2021; 3937. doi: 10.1038/s41467-021-24224-3

Vernieri C, Nichetti F, Lalli L, Moscetti L, Giorgi CA, Griguolo G, Marra A, Randon G, Rea CG, Ligorio F, Scagnoli S, De Angelis C, Molinelli C, Fabbri A, Ferraro E, Trapani D, Milani A, Agostinetto E, Bernocchi O, Catania G, Vantaggiato A, Palleschi M, Moretti A, Basile D, Cinausero M, Ajazi A, Castagnoli L, Lo Vullo S, Gerratana L, Puglisi F, La Verde N, Arpino G, Rocca A, Ciccarese M, Pedersini R, Fabi A, Generali D, Losurdo A, Montemurro F, Curigliano G, Del Mastro L, Michelotti A, Cortesi E, Guarneri V, Pruneri G, Mariani L, de Braud F

Impact of Baseline and On-Treatment Glycemia on Everolimus-Exemestane Efficacy in Patients with Hormone Receptor-Positive Advanced Breast Cancer (EVERMET).

Clin Cancer Res 2021; 3443-3455. doi: 10.1158/1078-0432.CCR-20-4928

Mangiameli E, Cecchele A, Morena F, Sanvito F, Matafora V, Cattaneo A, Della Volpe L, Gnani D, Paulis M, Susani L, Martino S, Di Micco R, Bachi A, Gritti A

Human iPSC-based neurodevelopmental models of globoid cell leukodystrophy uncover patient- and cell type-specific disease phenotypes.

Stem Cell Reports 2021; 1478-1495. doi: 10.1016/j.stemcr.2021.04.011

Matafora V, Lanzani C, Zagato L, Manunta P, Zacchia M, Trepiccione F, Simonini M, Capasso G, Bachi A

Urinary proteomics reveals key markers of salt sensitivity in hypertensive patients during saline infusion.

J Nephrol 2021; 739-751. doi: 10.1007/s40620-020-00877-z

Bonnal RJP, Rossetti G, Lugli E, De Simone M, Gruarin P, Brummelman J, Drufuca L, Passaro M, Bason R, Gervasoni F, Della Chiara G, D'Oria C, Martinovic M, Curti S, Ranzani V, Cordiglieri C, Alvisi G, Mazza EMC, Oliveto S, Silvestri Y, Carelli E, Mazzara S, Bosotti R, Sarnicola ML, Godano C, Bevilacqua V, Lorenzo M, Siena S, Bonoldi E, Sartore-Bianchi A, Amatu A, Veronesi G, Novellis P, Alloisio M, Giani A, Zucchini N, Opocher E, Ceretti AP, Mariani N, Biffo S, Prati D, Bardelli A, Geginat J, Lanzavecchia A, Abrignani S, Pagani M

Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression.

Nat Immunol 2021; 735-745. doi: 10.1038/s41590-021-00930-4

Uryga AK, Grootaert MOJ, Garrido AM, Oc S, Foote K, Chappell J, Finigan A, Rossiello F, d'Adda di Fagagna F, Aravani D, Jorgensen HF, Bennett MR

Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury.

Commun Biol 2021; 611. doi: 10.1038/s42003-021-02123-z

Bertocchi A, Carloni S, Ravenda PS, Bertalot G, Spadoni I, Lo Cascio A, Gandini S, Lizier M, Braga D, Asnicar F, Segata N, Klaver C, Brescia P, Rossi E, Anselmo A, Guglietta S, Maroli A, Spaggiari P, Tarazona N, Cervantes A, Marsoni S, Lazzari L, Jodice MG, Luise C, Erreni M, Pece S, Di Fiore PP, Viale G, Spinelli A, Pozzi C, Penna G, Rescigno M

Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver.

Cancer Cell 2021; 708-724.e11. doi: 10.1016/j.ccell.2021.03.004

Panlilio M, Grilli J, Tallarico G, Iuliani I, Sclavi B, Cicuta P, Cosentino Lagomarsino M

Threshold accumulation of a constitutive protein explains E. coli cell-division behavior in nutrient upshifts.

Proc Natl Acad Sci U S A 2021; . doi: 10.1073/pnas.2016391118

Arnone CM, Polito VA, Mastronuzzi A, Carai A, Diomedi FC, Antonucci L, Petrilli LL, Vinci M, Ferrari F, Salviato E, Scarsella M, De Stefanis C, Weber G, Quintarelli C, De Angelis B, Brenner MK, Gottschalk S, Hoyos V, Locatelli F, Caruana I, Del Bufalo F

Oncolytic adenovirus and gene therapy with EphA2-BiTE for the treatment of pediatric high-grade gliomas.

J Immunother Cancer 2021; . doi: 10.1136/jitc-2020-001930

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