Frittoli E, Palamidessi A, Pizzigoni A, Lanzetti L, Garrè M, Troglio F, Troilo A, Fukuda M, Di Fiore PP, Scita G, Confalonieri S

The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway.

Mol Biol Cell 2008; 1304-16. doi: 10.1091/mbc.e07-06-0594

Bosse T, Ehinger J, Czuchra A, Benesch S, Steffen A, Wu X, Schloen K, Niemann HH, Scita G, Stradal TE, Brakebusch C, Rottner K

Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways.

Mol Cell Biol 2007; 6615-28. doi: 10.1128/MCB.00367-07

Disanza A, Mantoani S, Hertzog M, Gerboth S, Frittoli E, Steffen A, Berhoerster K, Kreienkamp HJ, Milanesi F, Di Fiore PP, Ciliberto A, Stradal TE, Scita G

Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex.

Nat Cell Biol 2006; 1337-47. doi: 10.1038/ncb1502

Offenhäuser N, Castelletti D, Mapelli L, Soppo BE, Regondi MC, Rossi P, D'Angelo E, Frassoni C, Amadeo A, Tocchetti A, Pozzi B, Disanza A, Guarnieri D, Betsholtz C, Scita G, Heberlein U, Di Fiore PP

Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics.

Cell 2006; 213-26. doi: 10.1016/j.cell.2006.09.011

Katso RM, Pardo OE, Palamidessi A, Franz CM, Marinov M, De Laurentiis A, Downward J, Scita G, Ridley AJ, Waterfield MD, Arcaro A

Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms.

Mol Biol Cell 2006; 3729-44. doi: 10.1091/mbc.e05-11-1083

Khanday FA, Santhanam L, Kasuno K, Yamamori T, Naqvi A, Dericco J, Bugayenko A, Mattagajasingh I, Disanza A, Scita G, Irani K

Sos-mediated activation of rac1 by p66shc.

J Cell Biol 2006; 817-22. doi: 10.1083/jcb.200506001

Innocenti M, Gerboth S, Rottner K, Lai FP, Hertzog M, Stradal TE, Frittoli E, Didry D, Polo S, Disanza A, Benesch S, Di Fiore PP, Carlier MF, Scita G

Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes.

Nat Cell Biol 2005; 969-76. doi: 10.1038/ncb1304

Disanza A, Carlier MF, Stradal TE, Didry D, Frittoli E, Confalonieri S, Croce A, Wehland J, Di Fiore PP, Scita G

Eps8 controls actin-based motility by capping the barbed ends of actin filaments.

Nat Cell Biol 2004; 1180-8. doi: 10.1038/ncb1199

Croce A, Cassata G, Disanza A, Gagliani MC, Tacchetti C, Malabarba MG, Carlier MF, Scita G, Baumeister R, Di Fiore PP

A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans.

Nat Cell Biol 2004; 1173-9. doi: 10.1038/ncb1198

Stradal TE, Rottner K, Disanza A, Confalonieri S, Innocenti M, Scita G

Regulation of actin dynamics by WASP and WAVE family proteins.

Trends Cell Biol 2004; 303-11. doi: 10.1016/j.tcb.2004.04.007

Innocenti M, Zucconi A, Disanza A, Frittoli E, Areces LB, Steffen A, Stradal TE, Di Fiore PP, Carlier MF, Scita G

Abi1 is essential for the formation and activation of a WAVE2 signalling complex.

Nat Cell Biol 2004; 319-27. doi: 10.1038/ncb1105

Steffen A, Rottner K, Ehinger J, Innocenti M, Scita G, Wehland J, Stradal TE

Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.

EMBO J 2004; 749-59. doi: 10.1038/sj.emboj.7600084

Innocenti M, Frittoli E, Ponzanelli I, Falck JR, Brachmann SM, Di Fiore PP, Scita G

Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.

J Cell Biol 2003; 17-23. doi: 10.1083/jcb.200206079

Belli F, Testori A, Rivoltini L, Maio M, Andreola G, Sertoli MR, Gallino G, Piris A, Cattelan A, Lazzari I, Carrabba M, Scita G, Santantonio C, Pilla L, Tragni G, Lombardo C, Arienti F, Marchianò A, Queirolo P, Bertolini F, Cova A, Lamaj E, Ascani L, Camerini R, Corsi M, Cascinelli N, Lewis JJ, Srivastava P, Parmiani G

Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings.

J Clin Oncol 2002; 4169-80. doi: 10.1200/JCO.2002.09.134

Innocenti M, Tenca P, Frittoli E, Faretta M, Tocchetti A, Di Fiore PP, Scita G

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.

J Cell Biol 2002; 125-36. doi: 10.1083/jcb.200108035

Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP

The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.

Nature 2000; 374-7. doi: 10.1038/35042605

Scita G, Tenca P, Frittoli E, Tocchetti A, Innocenti M, Giardina G, Di Fiore PP

Signaling from Ras to Rac and beyond: not just a matter of GEFs.

EMBO J 2000; 2393-8. doi: 10.1093/emboj/19.11.2393

Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, Gutkind S, Bjarnegård M, Betsholtz C, Di Fiore PP

EPS8 and E3B1 transduce signals from Ras to Rac.

Nature 1999; 290-3. doi: 10.1038/45822

Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME

The SH3 domain of Eps8 exists as a novel intertwined dimer.

Nat Struct Biol 1997; 739-43. doi: 10.1038/nsb0997-739

Minucci S, Saint-Jeannet JP, Toyama R, Scita G, DeLuca LM, Tiara M, Levin AA, Ozato K, Dawid IB

Retinoid X receptor-selective ligands produce malformations in Xenopus embryos.

Proc Natl Acad Sci U S A 1996; 1803-7. doi: 10.1073/pnas.93.5.1803

Kagan VE, Serbinova EA, Forte T, Scita G, Packer L

Recycling of vitamin E in human low density lipoproteins.

J Lipid Res 1992; 385-97.

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