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Mechanisms of active wetting and fluidification in epithelial cell collectives.

Nat Mater 2026; . doi: 10.1038/s41563-026-02553-2

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Macrophages restrict tumor immune infiltration by controlling collagen topography.

Sci Immunol 2026; eadw8291. doi: 10.1126/sciimmunol.adw8291

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Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties.

Nat Mater 2026; . doi: 10.1038/s41563-025-02473-7

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Brillouin Microscopy of Breast tumor Spheroids On-a-Chip: Mechanical and Transcriptional Responses to Microfluidic-Induced Rapid Deformations.

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De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems.

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TRF2 interaction with nuclear envelope is required for cell polarization and metastasis in triple negative breast cancer.

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Biophysical and Molecular mechanisms that control active wetting and tissue fluidification in epithelial tissues.

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Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer.

bioRxiv 2024; . doi: 10.1101/2024.08.22.609159

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Mechanical stress during confined migration causes aberrant mitoses and c-MYC amplification.

Proc Natl Acad Sci U S A 2024; e2404551121. doi: 10.1073/pnas.2404551121

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A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism.

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A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale.

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Tissue fluidification promotes a cGAS-STING cytosolic DNA response in invasive breast cancer.

Nat Mater 2023; 644-655. doi: 10.1038/s41563-022-01431-x

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A planar-polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia.

bioRxiv 2023; . doi: 10.1101/2023.01.23.524898

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PillarX: A Microfluidic Device to Profile Circulating Tumor Cell Clusters Based on Geometry, Deformability, and Epithelial State.

Small 2022; e2106097. doi: 10.1002/smll.202106097

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Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis.

Nat Cell Biol 2021; 1073-1084. doi: 10.1038/s41556-021-00767-x

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Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion.

Cell 2021; 5230-5246.e22. doi: 10.1016/j.cell.2021.08.035

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ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration.

Nat Commun 2020; 4828. doi: 10.1038/s41467-020-18580-9

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IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules.

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A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior.

Nat Commun 2020; 3020. doi: 10.1038/s41467-020-16836-y

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Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma.

Nat Mater 2019; 1252-1263. doi: 10.1038/s41563-019-0425-1

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Is cell migration a selectable trait in the natural evolution of cancer development?

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Collagen Prolyl Hydroxylation-Dependent Metabolic Perturbation Governs Epigenetic Remodeling and Mesenchymal Transition in Pluripotent and Cancer Cells.

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Local actin nucleation tunes centrosomal microtubule nucleation during passage through mitosis.

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Inhibition of Cyclin-Dependent Kinase 5: A Strategy to Improve Sorafenib Response in Hepatocellular Carcinoma Therapy.

Hepatology 2019; 376-393. doi: 10.1002/hep.30190

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A NUMB-EFA6B-ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility.

J Cell Biol 2018; 3161-3182. doi: 10.1083/jcb.201802023

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Frustration-induced phases in migrating cell clusters.

Sci Adv 2018; eaar8483. doi: 10.1126/sciadv.aar8483

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Author Correction: A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.

Nat Commun 2018; 2085. doi: 10.1038/s41467-018-04515-y

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Co-optation of Tandem DNA Repeats for the Maintenance of Mesenchymal Identity.

Cell 2018; 1150-1164.e14. doi: 10.1016/j.cell.2018.03.081

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From jamming to collective cell migration through a boundary induced transition.

Soft Matter 2018; 3774-3782. doi: 10.1039/c8sm00128f

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A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.

Nat Commun 2018; 1475. doi: 10.1038/s41467-018-03571-8

Gerboth S, Frittoli E, Palamidessi A, Baltanas FC, Salek M, Rappsilber J, Giuliani C, Troglio F, Rolland Y, Pruneri G, Kreutmair S, Pallavicini I, Zobel M, Cinquanta M, Minucci S, Gomez C, Santos E, Illert AL, Scita G

Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.

Leukemia 2018; 820-827. doi: 10.1038/leu.2017.267

Tod J, Hanley CJ, Morgan MR, Rucka M, Mellows T, Lopez MA, Kiely P, Moutasim KA, Frampton SJ, Sabnis D, Fine DR, Johnson C, Marshall JF, Scita G, Jenei V, Thomas GJ

Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch.

J Pathol 2017; 37-50. doi: 10.1002/path.4923

Lőrincz P, Tóth S, Benkő P, Lakatos Z, Boda A, Glatz G, Zobel M, Bisi S, Hegedűs K, Takáts S, Scita G, Juhász G

Rab2 promotes autophagic and endocytic lysosomal degradation.

J Cell Biol 2017; 1937-1947. doi: 10.1083/jcb.201611027

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Endocytic reawakening of motility in jammed epithelia.

Nat Mater 2017; 587-596. doi: 10.1038/nmat4848

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