Palamidessi A, Testa I, Frittoli E, Barozzi S, Garrè M, Mazza D, Di Fiore PP, Diaspro A, Scita G, Faretta M

Understanding biological dynamics: following cells and molecules to track functions and mechanisms.

Eur Biophys J 2010; 947-57. doi: 10.1007/s00249-009-0461-x

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Ferrai C, Naum-Onganía G, Longobardi E, Palazzolo M, Disanza A, Diaz VM, Crippa MP, Scita G, Blasi F

Induction of HoxB transcription by retinoic acid requires actin polymerization.

Mol Biol Cell 2009; 3543-51. doi: 10.1091/mbc.e09-02-0114

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Yang C, Hoelzle M, Disanza A, Scita G, Svitkina T

Coordination of membrane and actin cytoskeleton dynamics during filopodia protrusion.

PLoS One 2009; e5678. doi: 10.1371/journal.pone.0005678

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Menna E, Disanza A, Cagnoli C, Schenk U, Gelsomino G, Frittoli E, Hertzog M, Offenhauser N, Sawallisch C, Kreienkamp HJ, Gertler FB, Di Fiore PP, Scita G, Matteoli M

Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF).

PLoS Biol 2009; e1000138. doi: 10.1371/journal.pbio.1000138

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Disanza A, Frittoli E, Palamidessi A, Scita G

Endocytosis and spatial restriction of cell signaling.

Mol Oncol 2009; 280-96. doi: 10.1016/j.molonc.2009.05.008

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Hu J, Troglio F, Mukhopadhyay A, Everingham S, Kwok E, Scita G, Craig AW

F-BAR-containing adaptor CIP4 localizes to early endosomes and regulates Epidermal Growth Factor Receptor trafficking and downregulation.

Cell Signal 2009; 1686-97. doi: 10.1016/j.cellsig.2009.07.007

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Giuliani C, Troglio F, Bai Z, Patel FB, Zucconi A, Malabarba MG, Disanza A, Stradal TB, Cassata G, Confalonieri S, Hardin JD, Soto MC, Grant BD, Scita G

Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.

PLoS Genet 2009; e1000675. doi: 10.1371/journal.pgen.1000675

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Chauhan BK, Disanza A, Choi SY, Faber SC, Lou M, Beggs HE, Scita G, Zheng Y, Lang RA

Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination.

Development 2009; 3657-67. doi: 10.1242/dev.042242

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Scita G, Di Fiore PP

The endocytic matrix.

Nature 2010; 464-73. doi: 10.1038/nature08910

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Welsch T, Younsi A, Disanza A, Rodriguez JA, Cuervo AM, Scita G, Schmidt J

Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cells.

Exp Cell Res 2010; 1914-24. doi: 10.1016/j.yexcr.2010.02.020

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Tocchetti A, Soppo CB, Zani F, Bianchi F, Gagliani MC, Pozzi B, Rozman J, Elvert R, Ehrhardt N, Rathkolb B, Moerth C, Horsch M, Fuchs H, Gailus-Durner V, Beckers J, Klingenspor M, Wolf E, Hrabé de Angelis M, Scanziani E, Tacchetti C, Scita G, Di Fiore PP, Offenhäuser N

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.

PLoS One 2010; e9468. doi: 10.1371/journal.pone.0009468

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Hertzog M, Milanesi F, Hazelwood L, Disanza A, Liu H, Perlade E, Malabarba MG, Pasqualato S, Maiolica A, Confalonieri S, Le Clainche C, Offenhauser N, Block J, Rottner K, Di Fiore PP, Carlier MF, Volkmann N, Hanein D, Scita G

Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping.

PLoS Biol 2010; e1000387. doi: 10.1371/journal.pbio.1000387

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Frittoli E, Palamidessi A, Disanza A, Scita G

Secretory and endo/exocytic trafficking in invadopodia formation: the MT1-MMP paradigm.

Eur J Cell Biol 2011; 108-14. doi: 10.1016/j.ejcb.2010.04.007

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De Laurentiis A, Pardo OE, Palamidessi A, Jackson SP, Schoenwaelder SM, Reichmann E, Scita G, Arcaro A

The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration.

Cell Signal 2011; 529-41. doi: 10.1016/j.cellsig.2010.10.021

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Manor U, Disanza A, Grati M, Andrade L, Lin H, Di Fiore PP, Scita G, Kachar B

Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8.

Curr Biol 2011; 167-72. doi: 10.1016/j.cub.2010.12.046

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Peleg B, Disanza A, Scita G, Gov N

Propagating cell-membrane waves driven by curved activators of actin polymerization.

PLoS One 2011; e18635. doi: 10.1371/journal.pone.0018635

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Frittoli E, Matteoli G, Palamidessi A, Mazzini E, Maddaluno L, Disanza A, Yang C, Svitkina T, Rescigno M, Scita G

The signaling adaptor Eps8 is an essential actin capping protein for dendritic cell migration.

Immunity 2011; 388-99. doi: 10.1016/j.immuni.2011.07.007

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Menna E, Fossati G, Scita G, Matteoli M

From filopodia to synapses: the role of actin-capping and anti-capping proteins.

Eur J Neurosci 2011; 1655-62. doi: 10.1111/j.1460-9568.2011.07897.x

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Crespi A, Ferrari I, Lonati P, Disanza A, Fornasari D, Scita G, Padovano V, Pietrini G

LIN7 regulates the filopodium- and neurite-promoting activity of IRSp53.

J Cell Sci 2012; 4543-54. doi: 10.1242/jcs.106484

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Wiedmann RM, von Schwarzenberg K, Palamidessi A, Schreiner L, Kubisch R, Liebl J, Schempp C, Trauner D, Vereb G, Zahler S, Wagner E, Müller R, Scita G, Vollmar AM

The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.

Cancer Res 2012; 5976-87. doi: 10.1158/0008-5472.CAN-12-1772

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Werner A, Disanza A, Reifenberger N, Habeck G, Becker J, Calabrese M, Urlaub H, Lorenz H, Schulman B, Scita G, Melchior F

SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression.

Nat Cell Biol 2013; 179-88. doi: 10.1038/ncb2661

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Bisi S, Disanza A, Malinverno C, Frittoli E, Palamidessi A, Scita G

Membrane and actin dynamics interplay at lamellipodia leading edge.

Curr Opin Cell Biol 2013; 565-73. doi: 10.1016/j.ceb.2013.04.001

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Malet-Engra G, Viaud J, Ysebaert L, Farcé M, Lafouresse F, Laurent G, Gaits-Iacovoni F, Scita G, Dupré L

CIP4 controls CCL19-driven cell steering and chemotaxis in chronic lymphocytic leukemia.

Cancer Res 2013; 3412-24. doi: 10.1158/0008-5472.CAN-12-3564

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Menna E, Zambetti S, Morini R, Donzelli A, Disanza A, Calvigioni D, Braida D, Nicolini C, Orlando M, Fossati G, Cristina Regondi M, Pattini L, Frassoni C, Francolini M, Scita G, Sala M, Fahnestock M, Matteoli M

Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity.

EMBO J 2013; 1730-44. doi: 10.1038/emboj.2013.107

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Ferrari I, Crespi A, Scita G, Pietrini G

LIN7-IRSp53: A novel pathway for filopodia and neurite formation?

Commun Integr Biol 2012; 631-3. doi: 10.4161/cib.21686

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Disanza A, Bisi S, Winterhoff M, Milanesi F, Ushakov DS, Kast D, Marighetti P, Romet-Lemonne G, Müller HM, Nickel W, Linkner J, Waterschoot D, Ampè C, Cortellino S, Palamidessi A, Dominguez R, Carlier MF, Faix J, Scita G

CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP.

EMBO J 2013; 2735-50. doi: 10.1038/emboj.2013.208

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Palamidessi A, Frittoli E, Ducano N, Offenhauser N, Sigismund S, Kajiho H, Parazzoli D, Oldani A, Gobbi M, Serini G, Di Fiore PP, Scita G, Lanzetti L

The GTPase-activating protein RN-tre controls focal adhesion turnover and cell migration.

Curr Biol 2013; 2355-64. doi: 10.1016/j.cub.2013.09.060

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Comes S, Gagliardi M, Laprano N, Fico A, Cimmino A, Palamidessi A, De Cesare D, De Falco S, Angelini C, Scita G, Patriarca EJ, Matarazzo MR, Minchiotti G

L-Proline induces a mesenchymal-like invasive program in embryonic stem cells by remodeling H3K9 and H3K36 methylation.

Stem Cell Reports 2013; 307-21. doi: 10.1016/j.stemcr.2013.09.001

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Maroni P, Bendinelli P, Matteucci E, Locatelli A, Nakamura T, Scita G, Desiderio MA

Osteolytic bone metastasis is hampered by impinging on the interplay among autophagy, anoikis and ossification.

Cell Death Dis 2014; e1005. doi: 10.1038/cddis.2013.465

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Kast DJ, Yang C, Disanza A, Boczkowska M, Madasu Y, Scita G, Svitkina T, Dominguez R

Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors.

Nat Struct Mol Biol 2014; 413-22. doi: 10.1038/nsmb.2781

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Frittoli E, Palamidessi A, Marighetti P, Confalonieri S, Bianchi F, Malinverno C, Mazzarol G, Viale G, Martin-Padura I, Garré M, Parazzoli D, Mattei V, Cortellino S, Bertalot G, Di Fiore PP, Scita G

A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination.

J Cell Biol 2014; 307-28. doi: 10.1083/jcb.201403127

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Rolland Y, Marighetti P, Malinverno C, Confalonieri S, Luise C, Ducano N, Palamidessi A, Bisi S, Kajiho H, Troglio F, Shcherbakova OG, Dunn AR, Oldani A, Lanzetti L, Di Fiore PP, Disanza A, Scita G

The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination.

Dev Cell 2014; 553-68. doi: 10.1016/j.devcel.2014.08.006

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Malet-Engra G, Yu W, Oldani A, Rey-Barroso J, Gov NS, Scita G, Dupré L

Collective cell motility promotes chemotactic prowess and resistance to chemorepulsion.

Curr Biol 2015; 242-250. doi: 10.1016/j.cub.2014.11.030

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Disanza A, Scita G

Nuclear and cellular plasticity: nuclear RAC1 takes center stage.

Dev Cell 2015; 261-3. doi: 10.1016/j.devcel.2015.01.015

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Corallino S, Malabarba MG, Zobel M, Di Fiore PP, Scita G

Epithelial-to-Mesenchymal Plasticity Harnesses Endocytic Circuitries.

Front Oncol 2015; 45. doi: 10.3389/fonc.2015.00045

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Linder S, Scita G

RABGTPases in MT1-MMP trafficking and cell invasion: Physiology versus pathology.

Small GTPases 2015; 145-52. doi: 10.4161/21541248.2014.985484

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Cremaschi P, Oliverio M, Leva V, Bione S, Carriero R, Mazzucco G, Palamidessi A, Scita G, Biamonti G, Montecucco A

Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells.

PLoS One 2015; e0130561. doi: 10.1371/journal.pone.0130561

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Giampietro C, Disanza A, Bravi L, Barrios-Rodiles M, Corada M, Frittoli E, Savorani C, Lampugnani MG, Boggetti B, Niessen C, Wrana JL, Scita G, Dejana E

The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling.

J Cell Biol 2015; 1177-92. doi: 10.1083/jcb.201501089

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Kajiho H, Kajiho Y, Frittoli E, Confalonieri S, Bertalot G, Viale G, Di Fiore PP, Oldani A, Garre M, Beznoussenko GV, Palamidessi A, Vecchi M, Chavrier P, Perez F, Scita G

RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs.

EMBO Rep 2016; 1061-80. doi: 10.15252/embr.201642032

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Sorrentino C, Boggio A, Confalonieri S, Hemenway D, Scita G, Ballabeni A

Increasing both the public health potential of basic research and the scientist satisfaction. An international survey of bio-scientists.

F1000Res 2016; 56. doi: 10.12688/f1000research.7683.2

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Ballabeni A, Hemenway D, Scita G

Time to tackle the incumbency advantage in science: A survey of scientists shows strong support for funding policies that would distribute funds more evenly among laboratories and thereby benefit new and smaller research groups.

EMBO Rep 2016; 1254-6. doi: 10.15252/embr.201642998

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Biondini M, Sadou-Dubourgnoux A, Paul-Gilloteaux P, Zago G, Arslanhan MD, Waharte F, Formstecher E, Hertzog M, Yu J, Guerois R, Gautreau A, Scita G, Camonis J, Parrini MC

Direct interaction between exocyst and Wave complexes promotes cell protrusions and motility.

J Cell Sci 2016; 3756-3769. doi: 10.1242/jcs.187336

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Chepizhko O, Giampietro C, Mastrapasqua E, Nourazar M, Ascagni M, Sugni M, Fascio U, Leggio L, Malinverno C, Scita G, Santucci S, Alava MJ, Zapperi S, La Porta CA

Bursts of activity in collective cell migration.

Proc Natl Acad Sci U S A 2016; 11408-11413. doi: 10.1073/pnas.1600503113

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Toffali L, Montresor A, Mirenda M, Scita G, Laudanna C

SOS1, ARHGEF1, and DOCK2 rho-GEFs Mediate JAK-Dependent LFA-1 Activation by Chemokines.

J Immunol 2017; 708-717. doi: 10.4049/jimmunol.1600933

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Delage E, Cervantes DC, Pénard E, Schmitt C, Syan S, Disanza A, Scita G, Zurzolo C

Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes.

Sci Rep 2016; 39632. doi: 10.1038/srep39632

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Kajiho H, Kajiho Y, Scita G

Harnessing membrane trafficking to promote cancer spreading and invasion: The case of RAB2A.

Small GTPases 2018; 304-309. doi: 10.1080/21541248.2016.1223990

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Malinverno C, Corallino S, Giavazzi F, Bergert M, Li Q, Leoni M, Disanza A, Frittoli E, Oldani A, Martini E, Lendenmann T, Deflorian G, Beznoussenko GV, Poulikakos D, Haur OK, Uroz M, Trepat X, Parazzoli D, Maiuri P, Yu W, Ferrari A, Cerbino R, Scita G

Endocytic reawakening of motility in jammed epithelia.

Nat Mater 2017; 587-596. doi: 10.1038/nmat4848

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Lőrincz P, Tóth S, Benkő P, Lakatos Z, Boda A, Glatz G, Zobel M, Bisi S, Hegedűs K, Takáts S, Scita G, Juhász G

Rab2 promotes autophagic and endocytic lysosomal degradation.

J Cell Biol 2017; 1937-1947. doi: 10.1083/jcb.201611027

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Tod J, Hanley CJ, Morgan MR, Rucka M, Mellows T, Lopez MA, Kiely P, Moutasim KA, Frampton SJ, Sabnis D, Fine DR, Johnson C, Marshall JF, Scita G, Jenei V, Thomas GJ

Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch.

J Pathol 2017; 37-50. doi: 10.1002/path.4923

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Gerboth S, Frittoli E, Palamidessi A, Baltanas FC, Salek M, Rappsilber J, Giuliani C, Troglio F, Rolland Y, Pruneri G, Kreutmair S, Pallavicini I, Zobel M, Cinquanta M, Minucci S, Gomez C, Santos E, Illert AL, Scita G

Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.

Leukemia 2018; 820-827. doi: 10.1038/leu.2017.267

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