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MITF controls the TCA cycle to modulate the melanoma hypoxia response.

Pigment Cell Melanoma Res 2019; 792-808. doi: 10.1111/pcmr.12802

Burdova K, Yang H, Faedda R, Hume S, Chauhan J, Ebner D, Kessler BM, Vendrell I, Drewry DH, Wells CI, Hatch SB, Dianov GL, Buffa FM, D'Angiolella V

E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition.

EMBO J 2019; e101443. doi: 10.15252/embj.2018101443

Carter R, Cheraghchi-Bashi A, Westhorpe A, Yu S, Shanneik Y, Seraia E, Ouaret D, Inoue Y, Koch C, Wilding J, Ebner D, Ryan AJ, Buffa FM, Sharma RA

Identification of anticancer drugs to radiosensitise BRAF-wild-type and mutant colorectal cancer.

Cancer Biol Med 2019; 234-246. doi: 10.20892/j.issn.2095-3941.2018.0284

Lord SR, Collins JM, Cheng WC, Haider S, Wigfield S, Gaude E, Fielding BA, Pinnick KE, Harjes U, Segaran A, Jha P, Hoefler G, Pollak MN, Thompson AM, Roy PG, English R, Adams RF, Frezza C, Buffa FM, Karpe F, Harris AL

Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin.

Br J Cancer 2020; 258-265. doi: 10.1038/s41416-019-0665-5

Dhawan A, Scott J, Sundaresan P, Veness M, Porceddu S, Hau E, Harris AL, Buffa FM, Gee HE

Role of gene signatures combined with pathology in classification of oropharynx head and neck cancer.

Sci Rep 2020; 10226. doi: 10.1038/s41598-020-66983-x

Di Giovannantonio M, Harris BH, Zhang P, Kitchen-Smith I, Xiong L, Sahgal N, Stracquadanio G, Wallace M, Blagden S, Lord S, Harris D, Harris AHL, Buffa FM, Bond GL

Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.

J Med Genet 2021; 392-399. doi: 10.1136/jmedgenet-2019-106799

Kawashima M, Bensaad K, Zois CE, Barberis A, Bridges E, Wigfield S, Lagerholm C, Dmitriev RI, Tokiwa M, Toi M, Papkovsky DB, Buffa FM, Harris AL

Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells.

Cancer Metab 2020; 13. doi: 10.1186/s40170-020-00219-4

Walsh CA, Akrap N, Garre E, Magnusson Y, Harrison H, Andersson D, Jonasson E, Rafnsdottir S, Choudhry H, Buffa F, Ragoussis J, Ståhlberg A, Harris A, Landberg G

The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer.

PLoS One 2020; e0236187. doi: 10.1371/journal.pone.0236187

Skwarski M, McGowan DR, Belcher E, Di Chiara F, Stavroulias D, McCole M, Derham JL, Chu KY, Teoh E, Chauhan J, O'Reilly D, Harris BHL, Macklin PS, Bull JA, Green M, Rodriguez-Berriguete G, Prevo R, Folkes LK, Campo L, Ferencz P, Croal PL, Flight H, Qi C, Holmes J, O'Connor JPB, Gleeson FV, McKenna WG, Harris AL, Bulte D, Buffa FM, Macpherson RE, Higgins GS

Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer.

Clin Cancer Res 2021; 2459-2469. doi: 10.1158/1078-0432.CCR-20-4128

Goedegebuure RSA, Kleibeuker EA, Buffa FM, Castricum KCM, Haider S, Schulkens IA, Ten Kroode L, van den Berg J, Jacobs MAJM, van Berkel AM, van Grieken NCT, Derks S, Slotman BJ, Verheul HMW, Harris AL, Thijssen VL

Interferon- and STING-independent induction of type I interferon stimulated genes during fractionated irradiation.

J Exp Clin Cancer Res 2021; 161. doi: 10.1186/s13046-021-01962-2

Hagel JP, Bennett K, Buffa F, Klenerman P, Willberg CB, Powell K

Defining T Cell Subsets in Human Tonsils Using ChipCytometry.

J Immunol 2021; 3073-3082. doi: 10.4049/jimmunol.2100063

Leach JDG, Vlahov N, Tsantoulis P, Ridgway RA, Flanagan DJ, Gilroy K, Sphyris N, Vázquez EG, Vincent DF, Faller WJ, Hodder MC, Raven A, Fey S, Najumudeen AK, Strathdee D, Nixon C, Hughes M, Clark W, Shaw R, van Hooff SR, Huels DJ, Medema JP, Barry ST, Frame MC, Unciti-Broceta A, Leedham SJ, Inman GJ, Jackstadt R, Thompson BJ, Campbell AD, Tejpar S, Sansom OJ

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.

Nat Commun 2021; 3464. doi: 10.1038/s41467-021-23717-5

Ramachandran S, Ma TS, Griffin J, Ng N, Foskolou IP, Hwang MS, Victori P, Cheng WC, Buffa FM, Leszczynska KB, El-Khamisy SF, Gromak N, Hammond EM

Hypoxia-induced SETX links replication stress with the unfolded protein response.

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Bader SB, Ma TS, Simpson CJ, Liang J, Maezono SEB, Olcina MM, Buffa FM, Hammond EM

Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity.

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Sheldon H, Bridges E, Silva I, Masiero M, Favara DM, Wang D, Leek R, Snell C, Roxanis I, Kreuzer M, Gileadi U, Buffa FM, Banham A, Harris AL

ADGRL4/ELTD1 Expression in Breast Cancer Cells Induces Vascular Normalization and Immune Suppression.

Mol Cancer Res 2021; 1957-1969. doi: 10.1158/1541-7786.MCR-21-0171

Chen Z, Ioris RM, Richardson S, Van Ess AN, Vendrell I, Kessler BM, Buffa FM, Busino L, Clifford SC, Bullock AN, D'Angiolella V

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.

Cell Death Differ 2022; 1955-1969. doi: 10.1038/s41418-022-00983-4

Zois CE, Hendriks AM, Haider S, Pires E, Bridges E, Kalamida D, Voukantsis D, Lagerholm BC, Fehrmann RSN, den Dunnen WFA, Tarasov AI, Baba O, Morris J, Buffa FM, McCullagh JSO, Jalving M, Harris AL

Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation.

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Chauhan JS, Hölzel M, Lambert JP, Buffa FM, Goding CR

The MITF regulatory network in melanoma.

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Kaeppler JR, Chen J, Buono M, Vermeer J, Kannan P, Cheng WC, Voukantsis D, Thompson JM, Hill MA, Allen D, Gomes A, Kersemans V, Kinchesh P, Smart S, Buffa F, Nerlov C, Muschel RJ, Markelc B

Endothelial cell death after ionizing radiation does not impair vascular structure in mouse tumor models.

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Harris BHL, Macaulay VM, Harris DA, Klenerman P, Karpe F, Lord SR, Harris AL, Buffa FM

Obesity: a perfect storm for carcinogenesis.

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Pasqualetti F, Rizzo M, Franceschi S, Lessi F, Paiar F, Buffa FM

New perspectives in liquid biopsy for glioma patients.

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Pai CC, Durley SC, Cheng WC, Chiang NY, Peters J, Kasparek T, Blaikley E, Wee BY, Walker C, Kearsey SE, Buffa F, Murray JM, Humphrey TC

Homologous recombination suppresses transgenerational DNA end resection and chromosomal instability in fission yeast.

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Pasqualetti F, Barberis A, Zanotti S, Montemurro N, De Salvo GL, Soffietti R, Mazzanti CM, Ius T, Caffo M, Paiar F, Bocci G, Lombardi G, Harris AL, Buffa FM

The impact of survivorship bias in glioblastoma research.

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Mehanna H, Rapozo D, von Zeidler SV, Harrington KJ, Winter SC, Hartley A, Nankivell P, Schache AG, Sloan P, Odell EW, Thavaraj S, Hunter KD, Shah KA, Thomas GJ, Long A, Amel-Kashipaz R, Brown RM, Conn B, Hall GL, Matthews P, Weir J, Yeo Y, Pring M, West CML, McCaul J, Golusinski P, Sitch A, Spruce R, Batis N, Bryant JL, Brooks JM, Jones TM, Buffa F, Haider S, Robinson M

Developing and Validating a Multivariable Prognostic-Predictive Classifier for Treatment Escalation of Oropharyngeal Squamous Cell Carcinoma: The PREDICTR-OPC Study.

Clin Cancer Res 2024; 356-367. doi: 10.1158/1078-0432.CCR-23-1013

Rodriguez-Berriguete G, Puliyadi R, Machado N, Barberis A, Prevo R, McLaughlin M, Buffa FM, Harrington KJ, Higgins GS

Antitumour effect of the mitochondrial complex III inhibitor Atovaquone in combination with anti-PD-L1 therapy in mouse cancer models.

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Domingo E, Rathee S, Blake A, Samuel L, Murray G, Sebag-Montefiore D, Gollins S, West N, Begum R, Richman S, Quirke P, Redmond K, Chatzipli A, Barberis A, Hassanieh S, Mahmood U, Youdell M, McDermott U, Koelzer V, Leedham S, Tomlinson I, Dunne P, Buffa FM, Maughan TS

Identification and validation of a machine learning model of complete response to radiation in rectal cancer reveals immune infiltrate and TGFβ as key predictors.

EBioMedicine 2024; 105228. doi: 10.1016/j.ebiom.2024.105228

Mahmood U, Blake A, Rathee S, Samuel L, Murray G, Sebag-Montefiore D, Gollins S, West NP, Begum R, Bach SP, Richman SD, Quirke P, Redmond KL, Salto-Tellez M, Koelzer VH, Leedham SJ, Tomlinson I, Dunne PD, Buffa FM, Maughan TS, Domingo E

Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures.

Cancer Res Commun 2024; 1765-1776. doi: 10.1158/2767-9764.CRC-23-0502

Yang H, Fouad S, Smith P, Bae EY, Ji Y, Lan X, Van Ess A, Buffa FM, Fischer R, Vendrell I, Kessler BM, D'Angiolella V

Cyclin F-EXO1 axis controls cell cycle-dependent execution of double-strand break repair.

Sci Adv 2024; eado0636. doi: 10.1126/sciadv.ado0636

Korpal M, Ell BJ, Buffa FM, Ibrahim T, Blanco MA, Celià-Terrassa T, Mercatali L, Khan Z, Goodarzi H, Hua Y, Wei Y, Hu G, Garcia BA, Ragoussis J, Amadori D, Harris AL, Kang Y

Editorial Expression of Concern: Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization.

Nat Med 2026; 768. doi: 10.1038/s41591-026-04242-8

Coupe N, Guo L, Bridges E, Campo L, Espinosa O, Colling R, Marshall A, Nandakumar A, van Stiphout R, Buffa FM, Corrie PG, Middleton MR, Macaulay VM

WNT5A-ROR2 axis mediates VEGF dependence of BRAF mutant melanoma.

Cell Oncol (Dordr) 2023; 391-407. doi: 10.1007/s13402-022-00757-7

Javaid H, Barberis A, Chervova O, Nassiri I, Voloshin V, Sato Y, Ogawa S, Fairfax B, Buffa F, Humphrey TC

A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation.

BMC Cancer 2023; 721. doi: 10.1186/s12885-023-11162-0

Triantafyllidis CP, Barberis A, Hartley F, Cuervo AM, Gjerga E, Charlton P, van Bijsterveldt L, Rodriguez JS, Buffa FM

A machine learning and directed network optimization approach to uncover TP53 regulatory patterns.

iScience 2023; 108291. doi: 10.1016/j.isci.2023.108291

Rao S, Verrill C, Cerundolo L, Alham NK, Kaya Z, O'Hanlon M, Hayes A, Lambert A, James M, Tullis IDC, Niederer J, Lovell S, Omer A, Lopez F, Leslie T, Buffa F, Bryant RJ, Lamb AD, Vojnovic B, Wedge DC, Mills IG, Woodcock DJ, Tomlinson I, Hamdy FC

Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features.

Genome Med 2024; 35. doi: 10.1186/s13073-024-01302-x

Jayathilake PG, Victori P, Pavillet CE, Lee CH, Voukantsis D, Miar A, Arora A, Harris AL, Morten KJ, Buffa FM

Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study.

PLoS Comput Biol 2024; e1011944. doi: 10.1371/journal.pcbi.1011944

Harris BHL, Di Giovannantonio M, Zhang P, Harris DA, Lord SR, Allen NE, Maughan TS, Bryant RJ, Harris AL, Bond GL, Buffa FM

New role of fat-free mass in cancer risk linked with genetic predisposition.

Sci Rep 2024; 7270. doi: 10.1038/s41598-024-54291-7

Sheldon H, Zhang W, Bridges E, Ang KH, Lin S, Masiero M, Li D, Handford PA, Whiteman P, Fischer R, Buffa F, Vatish M, Banham AH, Harris AL

ELTD1 is present in extracellular vesicles derived from endothelial cells as a cleaved extracellular domain which induces in vivo angiogenesis.

J Extracell Biol 2022; e52. doi: 10.1002/jex2.52

Schoenpflug LA, Chatzipli A, Sirinukunwattana K, Richman S, Blake A, Robineau J, Mertz KD, Verrill C, Leedham SJ, Hardy C, Whalley C, Redmond K, Dunne P, Walker S, Beggs AD, McDermott U, Murray GI, Samuel LM, Seymour M, Tomlinson I, Quirke P, Rittscher J, Maughan T, Domingo E, Koelzer VH

Tumour purity assessment with deep learning in colorectal cancer and impact on molecular analysis.

J Pathol 2025; 184-197. doi: 10.1002/path.6376

Di Giovannantonio M, Hartley F, Elshenawy B, Barberis A, Hudson D, Shafique HS, Allott VES, Harris DA, Lord SR, Haider S, Harris AL, Buffa FM, Harris BHL

Defining hypoxia in cancer: A landmark evaluation of hypoxia gene expression signatures.

Cell Genom 2025; 100764. doi: 10.1016/j.xgen.2025.100764

Ward JC, Morgan M, Wood J, Woolley C, de Menezes AAN, Finch A, Sherwood K, Huang Q, Henry CS, Fernández-Tajes J, Soriano I, Thorn S, Legge I, McCullagh J, Kerr D, Kerr R, Hejmadi RK, Arends MJ, Domingo E, Maughan T, Bardella C, Tomlinson I

Analysis of IDH1 and IDH2 mutations as causes of the hypermethylator phenotype in colorectal cancer.

J Pathol 2025; 40-55. doi: 10.1002/path.6446

Carter RD, Purnama U, Castro-Guarda M, Montes-Aparicio CN, Chandran A, Mbasu R, Ruby M, Daly C, Brisk K, Christian HC, Miller JJJJ, Buffa FM, Heather LC, Carr CA

Systems Biology and Functional Assessments of Human iPSC-Cardiomyocyte Models of Insulin Resistance Capture Key Hallmarks of Diabetic Cardiomyopathy.

Diabetes 2025; 1929-1945. doi: 10.2337/db25-0204

Tagliafico E, Tenedini E, Manfredini R, Grande A, Ferrari F, Roncaglia E, Bicciato S, Zini R, Salati S, Bianchi E, Gemelli C, Montanari M, Vignudelli T, Zanocco-Marani T, Parenti S, Paolucci P, Martinelli G, Piccaluga PP, Baccarani M, Specchia G, Torelli U, Ferrari S

Identification of a molecular signature predictive of sensitivity to differentiation induction in acute myeloid leukemia.

Leukemia 2006; 1751-8. doi: 10.1038/sj.leu.2404358

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