Publications

Vinciguerra M, El Kharef C, Bruhn C, Falbo L, Milanese C, Audano M, Beznoussenko GV, Mironov AA, Delia D, Foiani M, Mastroberardino PG, Mitro N, Costanzo V

Targeting the FNIP2-SERCA2b axis improves metabolic and mitochondrial defects in Ataxia Telangiectasia.

Cell Death Dis 2026; . doi: 10.1038/s41419-026-08507-5

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Sassi L, Martinez Marroquin A, Waked S, Ardizzoia A, Costanzo V

The expanding roles of homologous recombination proteins in genome stability.

EMBO J 2026; 637-654. doi: 10.1038/s44318-025-00673-0

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Zribi S, Giannitelli GJ, Bernardini L, Censi F, Camerini S, Bertuccini L, Iosi F, Giannella E, Sanchez M, Consoli E, Casagrande A, Cenci A, Floridia G, Novelli A, Giuliani A, Costanzo V, Crescenzi M, Pajalunga D

Structural obstruction to full DNA replication in terminally differentiated skeletal muscle cells.

EMBO Rep 2025; 4633-4655. doi: 10.1038/s44319-025-00554-x

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Peña-Gómez MJ, Rodríguez-Martín Y, Del Rio Oliva M, Wijesekara Hanthi Y, Berrada S, Freire R, Masson JY, Reyes JC, Costanzo V, Rosado IV

HMCES corrupts replication fork stability during base excision repair in homologous recombination-deficient cells.

Sci Adv 2025; eads3227. doi: 10.1126/sciadv.ads3227

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Hanthi YW, Ramirez-Otero MA, Appleby R, De Antoni A, Joudeh L, Sannino V, Waked S, Ardizzoia A, Barra V, Fachinetti D, Pellegrini L, Costanzo V

RAD51 protects abasic sites to prevent replication fork breakage.

Mol Cell 2024; 3026-3043.e11. doi: 10.1016/j.molcel.2024.07.004

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Moore CE, Yalcindag SE, Czeladko H, Ravindranathan R, Wijesekara Hanthi Y, Levy JC, Sannino V, Schindler D, Ciccia A, Costanzo V, Elia AEH

RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of stalled replication forks.

J Cell Biol 2023; . doi: 10.1083/jcb.202106022

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Lewis M, Terré B, Knobel PA, Cheng T, Lu H, Attolini CS, Smak J, Coyaud E, Garcia-Cao I, Sharma S, Vineethakumari C, Querol J, Gil-Gómez G, Piergiovanni G, Costanzo V, Peiró S, Raught B, Zhao H, Salvatella X, Roy S, Mahjoub MR, Stracker TH

GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program.

Cell Death Dis 2023; 201. doi: 10.1038/s41419-023-05720-4

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Schrempf A, Bernardo S, Arasa Verge EA, Ramirez Otero MA, Wilson J, Kirchhofer D, Timelthaler G, Ambros AM, Kaya A, Wieder M, Ecker GF, Winter GE, Costanzo V, Loizou JI

POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells.

Cell Rep 2022; 111716. doi: 10.1016/j.celrep.2022.111716

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Mann A, Ramirez-Otero MA, De Antoni A, Hanthi YW, Sannino V, Baldi G, Falbo L, Schrempf A, Bernardo S, Loizou J, Costanzo V

POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps.

Mol Cell 2022; 4218-4231.e8. doi: 10.1016/j.molcel.2022.09.013

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Taglialatela A, Leuzzi G, Sannino V, Cuella-Martin R, Huang JW, Wu-Baer F, Baer R, Costanzo V, Ciccia A

REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps.

Mol Cell 2021; 4008-4025.e7. doi: 10.1016/j.molcel.2021.08.016

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Kosar M, Giannattasio M, Piccini D, Maya-Mendoza A, García-Benítez F, Bartkova J, Barroso SI, Gaillard H, Martini E, Restuccia U, Ramirez-Otero MA, Garre M, Verga E, Andújar-Sánchez M, Maynard S, Hodny Z, Costanzo V, Kumar A, Bachi A, Aguilera A, Bartek J, Foiani M

The human nucleoporin Tpr protects cells from RNA-mediated replication stress.

Nat Commun 2021; 3937. doi: 10.1038/s41467-021-24224-3

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Falbo L, Costanzo V

Epigenetic regulation of replication origin assembly: A role for histone H1 and chromatin remodeling factors.

Bioessays 2021; e2000181. doi: 10.1002/bies.202000181

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Coquel F, Silva MJ, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, Promonet A, Cribier A, Sarrazin A, Niedzwiedz W, Lopez B, Costanzo V, Krejci L, Chabes A, Benkirane M, Lin YL, Pasero P

[SAMHD1 acts at stalled replication forks to prevent interferon induction].

C R Biol 2020; 9-21. doi: 10.5802/crbiol.10

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Atashpaz S, Samadi Shams S, Gonzalez JM, Sebestyén E, Arghavanifard N, Gnocchi A, Albers E, Minardi S, Faga G, Soffientini P, Allievi E, Cancila V, Bachi A, Fernández-Capetillo Ó, Tripodo C, Ferrari F, López-Contreras AJ, Costanzo V

ATR expands embryonic stem cell fate potential in response to replication stress.

Elife 2020; . doi: 10.7554/eLife.54756

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Falbo L, Raspelli E, Romeo F, Fiorani S, Pezzimenti F, Casagrande F, Costa I, Parazzoli D, Costanzo V

SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development.

Nat Commun 2020; 1345. doi: 10.1038/s41467-020-15180-5

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Ercilla A, Benada J, Amitash S, Zonderland G, Baldi G, Somyajit K, Ochs F, Costanzo V, Lukas J, Toledo L

Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication.

Cell Rep 2020; 2416-2429.e7. doi: 10.1016/j.celrep.2020.01.067

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Vernuccio F, Bruno A, Costanzo V, Bartolotta TV, Vieni S, Midiri M, Salvaggio G, Brancatelli G

Comparison of the Enhancement Pattern of Hepatic Hemangioma on Magnetic Resonance Imaging Performed With Gd-EOB-DTPA Versus Gd-BOPTA.

Curr Probl Diagn Radiol 2020; 398-403. doi: 10.1067/j.cpradiol.2019.06.006

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Costanzo V, Bardelli A, Siena S, Abrignani S

Exploring the links between cancer and placenta development.

Open Biol 2018; . doi: 10.1098/rsob.180081

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Srinivasan M, Scheinost JC, Petela NJ, Gligoris TG, Wissler M, Ogushi S, Collier JE, Voulgaris M, Kurze A, Chan KL, Hu B, Costanzo V, Nasmyth KA

The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as well as Topological Mechanisms.

Cell 2018; 1508-1519.e18. doi: 10.1016/j.cell.2018.04.015

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SAMHD1 acts at stalled replication forks to prevent interferon induction.

Nature 2018; 57-61. doi: 10.1038/s41586-018-0050-1

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Taglialatela A, Alvarez S, Leuzzi G, Sannino V, Ranjha L, Huang JW, Madubata C, Anand R, Levy B, Rabadan R, Cejka P, Costanzo V, Ciccia A

Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.

Mol Cell 2017; 414-430.e8. doi: 10.1016/j.molcel.2017.09.036

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Zadorozhny K, Sannino V, Beláň O, Mlčoušková J, Špírek M, Costanzo V, Krejčí L

Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection.

Cell Rep 2017; 333-340. doi: 10.1016/j.celrep.2017.09.062

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Kolinjivadi AM, Sannino V, De Antoni A, Zadorozhny K, Kilkenny M, Técher H, Baldi G, Shen R, Ciccia A, Pellegrini L, Krejci L, Costanzo V

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.

Mol Cell 2017; 867-881.e7. doi: 10.1016/j.molcel.2017.07.001

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Puddu F, Salguero I, Herzog M, Geisler NJ, Costanzo V, Jackson SP

Chromatin determinants impart camptothecin sensitivity.

EMBO Rep 2017; 1000-1012. doi: 10.15252/embr.201643560

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Kolinjivadi AM, Sannino V, de Antoni A, Técher H, Baldi G, Costanzo V

Moonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51.

FEBS Lett 2017; 1083-1100. doi: 10.1002/1873-3468.12556

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Raspelli E, Falbo L, Costanzo V

Xenopus egg extract to study regulation of genome-wide and locus-specific DNA replication.

Genesis 2017; . doi: 10.1002/dvg.22996

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Sannino V, Pezzimenti F, Bertora S, Costanzo V

Xenopus laevis as Model System to Study DNA Damage Response and Replication Fork Stability.

Methods Enzymol 2017; 211-232. doi: 10.1016/bs.mie.2017.03.018

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Bloom K, Costanzo V

Centromere Structure and Function.

Prog Mol Subcell Biol 2017; 515-539. doi: 10.1007/978-3-319-58592-5_21

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Sannino V, Costanzo V

ATR checkpoint suppression by repetitive DNA.

Cell Cycle 2016; 2993-2994. doi: 10.1080/15384101.2016.1204870

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Romeo F, Falbo L, Costanzo V

Replication, checkpoint suppression and structure of centromeric DNA.

Nucleus 2016; 540-546. doi: 10.1080/19491034.2016.1255836

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Aze A, Sannino V, Soffientini P, Bachi A, Costanzo V

Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression.

Nat Cell Biol 2016; 684-91. doi: 10.1038/ncb3344

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Simon AC, Sannino V, Costanzo V, Pellegrini L

Structure of human Cdc45 and implications for CMG helicase function.

Nat Commun 2016; 11638. doi: 10.1038/ncomms11638

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Terré B, Piergiovanni G, Segura-Bayona S, Gil-Gómez G, Youssef SA, Attolini CS, Wilsch-Bräuninger M, Jung C, Rojas AM, Marjanović M, Knobel PA, Palenzuela L, López-Rovira T, Forrow S, Huttner WB, Valverde MA, de Bruin A, Costanzo V, Stracker TH

GEMC1 is a critical regulator of multiciliated cell differentiation.

EMBO J 2016; 942-60. doi: 10.15252/embj.201592821

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Sannino V, Kolinjivadi AM, Baldi G, Costanzo V

Studying essential DNA metabolism proteins in Xenopus egg extract.

Int J Dev Biol 2016; 221-227. doi: 10.1387/ijdb.160103vc

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Marjanović M, Sánchez-Huertas C, Terré B, Gómez R, Scheel JF, Pacheco S, Knobel PA, Martínez-Marchal A, Aivio S, Palenzuela L, Wolfrum U, McKinnon PJ, Suja JA, Roig I, Costanzo V, Lüders J, Stracker TH

CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination.

Nat Commun 2015; 7676. doi: 10.1038/ncomms8676

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Vermezovic J, Adamowicz M, Santarpia L, Rustighi A, Forcato M, Lucano C, Massimiliano L, Costanzo V, Bicciato S, Del Sal G, d'Adda di Fagagna F

Notch is a direct negative regulator of the DNA-damage response.

Nat Struct Mol Biol 2015; 417-24. doi: 10.1038/nsmb.3013

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Olivera Harris M, Kallenberger L, Artola Borán M, Enoiu M, Costanzo V, Jiricny J

Mismatch repair-dependent metabolism of O6-methylguanine-containing DNA in Xenopus laevis egg extracts.

DNA Repair (Amst) 2015; 1-7. doi: 10.1016/j.dnarep.2015.01.014

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Bellelli R, Castellone MD, Guida T, Limongello R, Dathan NA, Merolla F, Cirafici AM, Affuso A, Masai H, Costanzo V, Grieco D, Fusco A, Santoro M, Carlomagno F