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RAG1/2 expression in IGH-switched follicular lymphoma associated with transformation to high-grade B-cell lymphoma.

Leukemia 2026; . doi: 10.1038/s41375-026-02896-4

Marcos-Kovandzic L, Avagliano M, Ben Khelil M, Srikanthan J, Abdallah R, Petrocelli V, Rengassamy J, Alfaro A, Bied M, Fidelle M, Ferrere G, Daillère R, Arbab A, Amine-Hneineh R, Pages A, Dartigues P, Ly P, Simon S, Durand S, Gottschlich A, Ginhoux F, Blériot C, Liu P, Zhao L, Creusot L, Rolhion N, Derosa L, Kroemer G, Menger L, Kobold S, Castilla-Llorente C, Sokol H, Casola S, Pasolli E, Zitvogel L, Bigenwald C

Gut Microbiota Modulation through Akkermansia spp. Supplementation Increases CAR T-cell Potency.

Cancer Discov 2025; 1905-1926. doi: 10.1158/2159-8290.CD-24-1230

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B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with MYC and BCL2 Rearrangements.

Blood Cancer Discov 2025; 364-393. doi: 10.1158/2643-3230.BCD-25-0099

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Reactive Bcl2-positive germinal centres in paediatric tonsils: expanding the spectrum of lymphoma mimickers in children and adolescents.

Histopathology 2025; 145-152. doi: 10.1111/his.15460

Raucci F, Vernieri C, Di Tano M, Ligorio F, Blaževitš O, Lazzeri S, Shmahala A, Fragale G, Salvadori G, Varano G, Casola S, Buono R, Visco E, de Braud F, Longo VD

Cyclic Fasting-Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia.

Cancer Res 2024; 1133-1148. doi: 10.1158/0008-5472.CAN-23-0295

Hariprakash JM, Salviato E, La Mastra F, Sebestyén E, Tagliaferri I, Silva RS, Lucini F, Farina L, Cinquanta M, Rancati I, Riboni M, Minardi SP, Roz L, Gorini F, Lanzuolo C, Casola S, Ferrari F

Leveraging Tissue-Specific Enhancer-Target Gene Regulatory Networks Identifies Enhancer Somatic Mutations That Functionally Impact Lung Cancer.

Cancer Res 2024; 133-153. doi: 10.1158/0008-5472.CAN-23-1129

Tripodo C, Zanardi F, Iannelli F, Mazzara S, Vegliante M, Morello G, Di Napoli A, Mangogna A, Facchetti F, Sangaletti S, Chiodoni C, VanShoiack A, Jeyasekharan AD, Casola S, Colombo MP, Ponzoni M, Pileri SA

A Spatially Resolved Dark- versus Light-Zone Microenvironment Signature Subdivides Germinal Center-Related Aggressive B Cell Lymphomas.

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Eur J Immunol 2019; 1457-1973. doi: 10.1002/eji.201970107

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Impact of systemic and tumor lipid metabolism on everolimus efficacy in advanced pancreatic neuroendocrine tumors (pNETs).

Int J Cancer 2019; 1704-1712. doi: 10.1002/ijc.32042

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Individuals with FANCM biallelic mutations do not develop Fanconi anemia, but show risk for breast cancer, chemotherapy toxicity and may display chromosome fragility.

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The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.

Nature 2017; 302-306. doi: 10.1038/nature22353

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EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells.

Cell Rep 2017; 1270-1284. doi: 10.1016/j.celrep.2017.01.020

Mihailovich M, Bremang M, Spadotto V, Musiani D, Vitale E, Varano G, Zambelli F, Mancuso FM, Cairns DA, Pavesi G, Casola S, Bonaldi T

miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth.

Nat Commun 2015; 8725. doi: 10.1038/ncomms9725

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An epigenetic view of B-cell disorders.

Immunol Cell Biol 2015; 253-60. doi: 10.1038/icb.2014.116

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Antibody repertoire diversification through VH gene replacement in mice cloned from an IgA plasma cell.

Proc Natl Acad Sci U S A 2015; E450-7. doi: 10.1073/pnas.1417988112

Simonetti G, Bertilaccio MT, Rodriguez TV, Apollonio B, Dagklis A, Rocchi M, Innocenzi A, Casola S, Winkler TH, Nitschke L, Ponzoni M, Caligaris-Cappio F, Ghia P

SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.

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Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication.

Nat Commun 2014; 3649. doi: 10.1038/ncomms4649

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Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis.

J Clin Invest 2013; 5009-22. doi: 10.1172/JCI70626

Fogli LK, Sundrud MS, Goel S, Bajwa S, Jensen K, Derudder E, Sun A, Coffre M, Uyttenhove C, Van Snick J, Schmidt-Supprian M, Rao A, Grunig G, Durbin J, Casola S, Rajewsky K, Koralov SB

T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia.

J Immunol 2013; 3100-11. doi: 10.4049/jimmunol.1301360

Lechouane F, Bonaud A, Delpy L, Casola S, Oruc Z, Chemin G, Cogné M, Sirac C

B-cell receptor signal strength influences terminal differentiation.

Eur J Immunol 2013; 619-28. doi: 10.1002/eji.201242912

Pengo N, Scolari M, Oliva L, Milan E, Mainoldi F, Raimondi A, Fagioli C, Merlini A, Mariani E, Pasqualetto E, Orfanelli U, Ponzoni M, Sitia R, Casola S, Cenci S

Plasma cells require autophagy for sustainable immunoglobulin production.

Nat Immunol 2013; 298-305. doi: 10.1038/ni.2524

Fragola G, Germain PL, Laise P, Cuomo A, Blasimme A, Gross F, Signaroldi E, Bucci G, Sommer C, Pruneri G, Mazzarol G, Bonaldi T, Mostoslavsky G, Casola S, Testa G

Cell reprogramming requires silencing of a core subset of polycomb targets.

PLoS Genet 2013; e1003292. doi: 10.1371/journal.pgen.1003292

Burgold T, Voituron N, Caganova M, Tripathi PP, Menuet C, Tusi BK, Spreafico F, Bévengut M, Gestreau C, Buontempo S, Simeone A, Kruidenier L, Natoli G, Casola S, Hilaire G, Testa G

The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival.

Cell Rep 2012; 1244-58. doi: 10.1016/j.celrep.2012.09.013

Zhang B, Kracker S, Yasuda T, Casola S, Vanneman M, Hömig-Hölzel C, Wang Z, Derudder E, Li S, Chakraborty T, Cotter SE, Koyama S, Currie T, Freeman GJ, Kutok JL, Rodig SJ, Dranoff G, Rajewsky K

Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model.

Cell 2012; 739-51. doi: 10.1016/j.cell.2011.12.031

Pozzi B, Amodio S, Lucano C, Sciullo A, Ronzoni S, Castelletti D, Adler T, Treise I, Betsholtz IH, Rathkolb B, Busch DH, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Betsholtz C, Casola S, Di Fiore PP, Offenhäuser N

The endocytic adaptor Eps15 controls marginal zone B cell numbers.

PLoS One 2012; e50818. doi: 10.1371/journal.pone.0050818

Sakurai N, Maeda M, Lee SU, Ishikawa Y, Li M, Williams JC, Wang L, Su L, Suzuki M, Saito TI, Chiba S, Casola S, Yagita H, Teruya-Feldstein J, Tsuzuki S, Bhatia R, Maeda T

The LRF transcription factor regulates mature B cell development and the germinal center response in mice.

J Clin Invest 2011; 2583-98. doi: 10.1172/JCI45682

Pasi CE, Dereli-Öz A, Negrini S, Friedli M, Fragola G, Lombardo A, Van Houwe G, Naldini L, Casola S, Testa G, Trono D, Pelicci PG, Halazonetis TD

Genomic instability in induced stem cells.

Cell Death Differ 2011; 745-53. doi: 10.1038/cdd.2011.9

Omodei D, Acampora D, Russo F, De Filippi R, Severino V, Di Francia R, Frigeri F, Mancuso P, De Chiara A, Pinto A, Casola S, Simeone A

Expression of the brain transcription factor OTX1 occurs in a subset of normal germinal-center B cells and in aggressive Non-Hodgkin Lymphoma.

Am J Pathol 2009; 2609-17. doi: 10.2353/ajpath.2009.090542

De Santa F, Narang V, Yap ZH, Tusi BK, Burgold T, Austenaa L, Bucci G, Caganova M, Notarbartolo S, Casola S, Testa G, Sung WK, Wei CL, Natoli G

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages.

EMBO J 2009; 3341-52. doi: 10.1038/emboj.2009.271

Hikida M, Casola S, Takahashi N, Kaji T, Takemori T, Rajewsky K, Kurosaki T

PLC-gamma2 is essential for formation and maintenance of memory B cells.

J Exp Med 2009; 681-9. doi: 10.1084/jem.20082100

Hao Z, Duncan GS, Seagal J, Su YW, Hong C, Haight J, Chen NJ, Elia A, Wakeham A, Li WY, Liepa J, Wood GA, Casola S, Rajewsky K, Mak TW

Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis.

Immunity 2008; 615-27. doi: 10.1016/j.immuni.2008.07.016

Hömig-Hölzel C, Hojer C, Rastelli J, Casola S, Strobl LJ, Müller W, Quintanilla-Martinez L, Gewies A, Ruland J, Rajewsky K, Zimber-Strobl U

Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis.

J Exp Med 2008; 1317-29. doi: 10.1084/jem.20080238

Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K

Regulation of the germinal center response by microRNA-155.

Science 2007; 604-8. doi: 10.1126/science.1141229

Klein U, Casola S, Cattoretti G, Shen Q, Lia M, Mo T, Ludwig T, Rajewsky K, Dalla-Favera R

Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.

Nat Immunol 2006; 773-82. doi: 10.1038/ni1357

Casola S, Cattoretti G, Uyttersprot N, Koralov SB, Seagal J, Hao Z, Waisman A, Egert A, Ghitza D, Rajewsky K

Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting.

Proc Natl Acad Sci U S A 2006; 7396-401. doi: 10.1073/pnas.0602353103

Novobrantseva TI, Majeau GR, Amatucci A, Kogan S, Brenner I, Casola S, Shlomchik MJ, Koteliansky V, Hochman PS, Ibraghimov A

Attenuated liver fibrosis in the absence of B cells.

J Clin Invest 2005; 3072-82. doi: 10.1172/JCI24798

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