Donzelli S, Cioce M, Sacconi A, Zanconato F, Daralioti T, Goeman F, Orlandi G, Di Martino S, Fazio VM, Alessandrini G, Telera S, Carosi M, Ciliberto G, Botti C, Strano S, Piccolo S, Blandino G

A PIK3CA-mutant breast cancer metastatic patient-derived organoid approach to evaluate alpelisib treatment for multiple secondary lesions.

Mol Cancer 2022; 152. doi: 10.1186/s12943-022-01617-6

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Piccolo S, Panciera T, Contessotto P, Cordenonsi M

YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches.

Nat Cancer 2023; 9-26. doi: 10.1038/s43018-022-00473-z

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Vanni G, Citron A, Suli A, Contessotto P, Caire R, Gandin A, Mantovan G, Zanconato F, Brusatin G, Di Palma M, Peirano E, Pozzer LS, Albanese C, Steiner RA, Cordenonsi M, Panciera T, Piccolo S

Microtubule architecture connects AMOT stability to YAP/TAZ mechanotransduction and Hippo signalling.

Nat Cell Biol 2025; 1725-1738. doi: 10.1038/s41556-025-01773-z

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Costanzo V, Avvedimento EV, Gottesman ME, Gautier J, Grieco D

Protein kinase A is required for chromosomal DNA replication.

Curr Biol 1999; 903-6. doi: 10.1016/s0960-9822(99)80395-9

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Costanzo V, Robertson K, Ying CY, Kim E, Avvedimento E, Gottesman M, Grieco D, Gautier J

Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage.

Mol Cell 2000; 649-59. doi: 10.1016/s1097-2765(00)00063-0

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Greenwood J, Costanzo V, Robertson K, Hensey C, Gautier J

Responses to DNA damage in Xenopus: cell death or cell cycle arrest.

Novartis Found Symp 2001; 221-30; discussion 230-4. doi: 10.1002/0470846666.ch17

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Costanzo V, Robertson K, Bibikova M, Kim E, Grieco D, Gottesman M, Carroll D, Gautier J

Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.

Mol Cell 2001; 137-47. doi: 10.1016/s1097-2765(01)00294-5

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D'Angiolella V, Costanzo V, Gottesman ME, Avvedimento EV, Gautier J, Grieco D

Role for cyclin-dependent kinase 2 in mitosis exit.

Curr Biol 2001; 1221-6. doi: 10.1016/s0960-9822(01)00352-9

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Vitolo OV, Sant'Angelo A, Costanzo V, Battaglia F, Arancio O, Shelanski M

Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling.

Proc Natl Acad Sci U S A 2002; 13217-21. doi: 10.1073/pnas.172504199

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Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J

An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication.

Mol Cell 2003; 203-13. doi: 10.1016/s1097-2765(02)00799-2

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Costanzo V, Gautier J

Single-strand DNA gaps trigger an ATR- and Cdc7-dependent checkpoint.

Cell Cycle 2003; 17. doi: 10.4161/cc.2.1.290

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Costanzo V, Gautier J

Xenopus cell-free extracts to study DNA damage checkpoints.

Methods Mol Biol 2004; 255-67. doi: 10.1385/1-59259-646-0:255

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Costanzo V, Paull T, Gottesman M, Gautier J

Mre11 assembles linear DNA fragments into DNA damage signaling complexes.

PLoS Biol 2004; E110. doi: 10.1371/journal.pbio.0020110

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Costanzo V, Robertson K, Gautier J

Xenopus cell-free extracts to study the DNA damage response.

Methods Mol Biol 2004; 213-27. doi: 10.1385/1-59259-788-2:213

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Shechter D, Costanzo V, Gautier J

ATR and ATM regulate the timing of DNA replication origin firing.

Nat Cell Biol 2004; 648-55. doi: 10.1038/ncb1145

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Shechter D, Costanzo V, Gautier J

Regulation of DNA replication by ATR: signaling in response to DNA intermediates.

DNA Repair (Amst) 2004; 901-8. doi: 10.1016/j.dnarep.2004.03.020

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Sobeck A, Stone S, Costanzo V, de Graaf B, Reuter T, de Winter J, Wallisch M, Akkari Y, Olson S, Wang W, Joenje H, Christian JL, Lupardus PJ, Cimprich KA, Gautier J, Hoatlin ME

Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks.

Mol Cell Biol 2006; 425-37. doi: 10.1128/MCB.26.2.425-437.2006

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Trenz K, Smith E, Smith S, Costanzo V

ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks.

EMBO J 2006; 1764-74. doi: 10.1038/sj.emboj.7601045

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D'Angiolella V, Palazzo L, Santarpia C, Costanzo V, Grieco D

Role for non-proteolytic control of M-phase-promoting factor activity at M-phase exit.

PLoS One 2007; e247. doi: 10.1371/journal.pone.0000247

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Errico A, Costanzo V, Hunt T

Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts.

Proc Natl Acad Sci U S A 2007; 14929-34. doi: 10.1073/pnas.0706347104

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Trenz K, Errico A, Costanzo V

Plx1 is required for chromosomal DNA replication under stressful conditions.

EMBO J 2008; 876-85. doi: 10.1038/emboj.2008.29

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Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V

Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity.

EMBO J 2008; 1953-62. doi: 10.1038/emboj.2008.128

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Takaki T, Trenz K, Costanzo V, Petronczki M

Polo-like kinase 1 reaches beyond mitosis--cytokinesis, DNA damage response, and development.

Curr Opin Cell Biol 2008; 650-60. doi: 10.1016/j.ceb.2008.10.005

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Smith E, Dejsuphong D, Balestrini A, Hampel M, Lenz C, Takeda S, Vindigni A, Costanzo V

An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63.

Nat Cell Biol 2009; 278-85. doi: 10.1038/ncb1835

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Garner E, Costanzo V

Studying the DNA damage response using in vitro model systems.

DNA Repair (Amst) 2009; 1025-37. doi: 10.1016/j.dnarep.2009.04.015

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Brown N, Costanzo V

An ATM and ATR dependent pathway targeting centrosome dependent spindle assembly.

Cell Cycle 2009; 1997-2001. doi: 10.4161/cc.8.13.8987

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Smith E, Costanzo V

Responding to chromosomal breakage during M-phase: insights from a cell-free system.

Cell Div 2009; 15. doi: 10.1186/1747-1028-4-15

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Costanzo V, Chaudhuri J, Fung JC, Moran JV

Dealing with dangerous accidents: DNA double-strand breaks take centre stage. Symposium on Genome Instability and DNA Repair.

EMBO Rep 2009; 837-42. doi: 10.1038/embor.2009.173

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Errico A, Cosentino C, Rivera T, Losada A, Schwob E, Hunt T, Costanzo V

Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion.

EMBO J 2009; 3681-92. doi: 10.1038/emboj.2009.304

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Errico A, Costanzo V

Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknowns.

EMBO Rep 2010; 270-8. doi: 10.1038/embor.2010.27

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Balestrini A, Cosentino C, Errico A, Garner E, Costanzo V

GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication.

Nat Cell Biol 2010; 484-91. doi: 10.1038/ncb2050

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Piergiovanni G, Costanzo V

GEMC1 is a novel TopBP1-interacting protein involved in chromosomal DNA replication.

Cell Cycle 2010; 3662-6. doi: 10.4161/cc.9.18.13060

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Hashimoto Y, Ray Chaudhuri A, Lopes M, Costanzo V

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis.

Nat Struct Mol Biol 2010; 1305-11. doi: 10.1038/nsmb.1927

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Cosentino C, Grieco D, Costanzo V

ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair.

EMBO J 2011; 546-55. doi: 10.1038/emboj.2010.330

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Hashimoto Y, Costanzo V

Studying DNA replication fork stability in Xenopus egg extract.

Methods Mol Biol 2011; 437-45. doi: 10.1007/978-1-61779-129-1_25

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Costanzo V

Brca2, Rad51 and Mre11: performing balancing acts on replication forks.

DNA Repair (Amst) 2011; 1060-5. doi: 10.1016/j.dnarep.2011.07.009

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Hashimoto Y, Puddu F, Costanzo V

RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks.

Nat Struct Mol Biol 2011; 17-24. doi: 10.1038/nsmb.2177

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Lazzaro F, Novarina D, Amara F, Watt DL, Stone JE, Costanzo V, Burgers PM, Kunkel TA, Plevani P, Muzi-Falconi M

RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA.

Mol Cell 2012; 99-110. doi: 10.1016/j.molcel.2011.12.019

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Errico A, Costanzo V

Mechanisms of replication fork protection: a safeguard for genome stability.

Crit Rev Biochem Mol Biol 2012; 222-35. doi: 10.3109/10409238.2012.655374

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Ray Chaudhuri A, Hashimoto Y, Herrador R, Neelsen KJ, Fachinetti D, Bermejo R, Cocito A, Costanzo V, Lopes M

Topoisomerase I poisoning results in PARP-mediated replication fork reversal.

Nat Struct Mol Biol 2012; 417-23. doi: 10.1038/nsmb.2258

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Zhao Z, Oh S, Li D, Ni D, Pirooz SD, Lee JH, Yang S, Lee JY, Ghozalli I, Costanzo V, Stark JM, Liang C

A dual role for UVRAG in maintaining chromosomal stability independent of autophagy.

Dev Cell 2012; 1001-16. doi: 10.1016/j.devcel.2011.12.027

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Aze A, Zhou JC, Costa A, Costanzo V

DNA replication and homologous recombination factors: acting together to maintain genome stability.

Chromosoma 2013; 401-13. doi: 10.1007/s00412-013-0411-3

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Brown NJ, Marjanović M, Lüders J, Stracker TH, Costanzo V

Cep63 and cep152 cooperate to ensure centriole duplication.

PLoS One 2013; e69986. doi: 10.1371/journal.pone.0069986

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Palazzo L, Della Monica R, Visconti R, Costanzo V, Grieco D

ATM controls proper mitotic spindle structure.

Cell Cycle 2014; 1091-100. doi: 10.4161/cc.27945

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Errico A, Aze A, Costanzo V

Mta2 promotes Tipin-dependent maintenance of replication fork integrity.

Cell Cycle 2014; 2120-8. doi: 10.4161/cc.29157

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Bellelli R, Castellone MD, Guida T, Limongello R, Dathan NA, Merolla F, Cirafici AM, Affuso A, Masai H, Costanzo V, Grieco D, Fusco A, Santoro M, Carlomagno F

NCOA4 transcriptional coactivator inhibits activation of DNA replication origins.

Mol Cell 2014; 123-37. doi: 10.1016/j.molcel.2014.04.031

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Olivera Harris M, Kallenberger L, Artola Borán M, Enoiu M, Costanzo V, Jiricny J

Mismatch repair-dependent metabolism of O6-methylguanine-containing DNA in Xenopus laevis egg extracts.

DNA Repair (Amst) 2015; 1-7. doi: 10.1016/j.dnarep.2015.01.014

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Marjanović M, Sánchez-Huertas C, Terré B, Gómez R, Scheel JF, Pacheco S, Knobel PA, Martínez-Marchal A, Aivio S, Palenzuela L, Wolfrum U, McKinnon PJ, Suja JA, Roig I, Costanzo V, Lüders J, Stracker TH

CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination.

Nat Commun 2015; 7676. doi: 10.1038/ncomms8676

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Terré B, Piergiovanni G, Segura-Bayona S, Gil-Gómez G, Youssef SA, Attolini CS, Wilsch-Bräuninger M, Jung C, Rojas AM, Marjanović M, Knobel PA, Palenzuela L, López-Rovira T, Forrow S, Huttner WB, Valverde MA, de Bruin A, Costanzo V, Stracker TH

GEMC1 is a critical regulator of multiciliated cell differentiation.

EMBO J 2016; 942-60. doi: 10.15252/embj.201592821

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Simon AC, Sannino V, Costanzo V, Pellegrini L

Structure of human Cdc45 and implications for CMG helicase function.

Nat Commun 2016; 11638. doi: 10.1038/ncomms11638

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