Fiorito V, Allocco AL, Petrillo S, Gazzano E, Torretta S, Marchi S, Destefanis F, Pacelli C, Audrito V, Provero P, Medico E, Chiabrando D, Porporato PE, Cancelliere C, Bardelli A, Trusolino L, Capitanio N, Deaglio S, Altruda F, Pinton P, Cardaci S, Riganti C, Tolosano E

The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation.

Cell Rep 2021; 109252. doi: 10.1016/j.celrep.2021.109252

Invrea F, Punzi S, Petti C, Minelli R, Peoples MD, Bristow CA, Vurchio V, Corrado A, Bragoni A, Marchiò C, Bertotti A, Trusolino L, Bardelli A, Isella C, Carugo A, Draetta GF, Medico E

Synthetic Lethality Screening Highlights Colorectal Cancer Vulnerability to Concomitant Blockade of NEDD8 and EGFR Pathways.

Cancers (Basel) 2021; . doi: 10.3390/cancers13153805

Pignochino Y, Crisafulli G, Giordano G, Merlini A, Berrino E, Centomo ML, Chiabotto G, Brusco S, Basiricò M, Maldi E, Pisacane A, Leuci V, Sangiolo D, D'Ambrosio L, Aglietta M, Kasper B, Bardelli A, Grignani G

PARP1 Inhibitor and Trabectedin Combination Does Not Increase Tumor Mutational Burden in Advanced Sarcomas-A Preclinical and Translational Study.

Cancers (Basel) 2021; . doi: 10.3390/cancers13246295

Allocco AL, Bertino F, Petrillo S, Chiabrando D, Riganti C, Bardelli A, Altruda F, Fiorito V, Tolosano E

Inhibition of Heme Export and/or Heme Synthesis Potentiates Metformin Anti-Proliferative Effect on Cancer Cell Lines.

Cancers (Basel) 2022; . doi: 10.3390/cancers14051230

Wan JCM, Mughal TI, Razavi P, Dawson SJ, Moss EL, Govindan R, Tan IB, Yap YS, Robinson WA, Morris CD, Besse B, Bardelli A, Tie J, Kopetz S, Rosenfeld N

Liquid biopsies for residual disease and recurrence.

Med 2021; 1292-1313. doi: 10.1016/j.medj.2021.11.001

Pergolizzi M, Bizzozero L, Maione F, Maldi E, Isella C, Macagno M, Mariella E, Bardelli A, Medico E, Marchiò C, Serini G, Di Nicolantonio F, Bussolino F, Arese M

The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway.

J Exp Clin Cancer Res 2022; 266. doi: 10.1186/s13046-022-02465-4

Merlini A, Centomo ML, Ferrero G, Chiabotto G, Miglio U, Berrino E, Giordano G, Brusco S, Pisacane A, Maldi E, Sarotto I, Capozzi F, Lano C, Isella C, Crisafulli G, Aglietta M, Dei Tos AP, Sbaraglia M, Sangiolo D, D'Ambrosio L, Bardelli A, Pignochino Y, Grignani G

DNA damage response and repair genes in advanced bone and soft tissue sarcomas: An 8-gene signature as a candidate predictive biomarker of response to trabectedin and olaparib combination.

Front Oncol 2022; 844250. doi: 10.3389/fonc.2022.844250

Khawaja H, Briggs R, Latimer CH, Rassel M, Griffin D, Hanson L, Bardelli A, Di Nicolantonio F, McDade SS, Scott CJ, Lambe S, Maurya M, Lindner AU, Prehn JHM, Sousa J, Winnington C, LaBonte MJ, Ross S, Van Schaeybroeck S

Bcl-xL Is a Key Mediator of Apoptosis Following KRASG12C Inhibition in KRASG12C-mutant Colorectal Cancer.

Mol Cancer Ther 2023; 135-149. doi: 10.1158/1535-7163.MCT-22-0301

Flanagan DJ, Amirkhah R, Vincent DF, Gunduz N, Gentaz P, Cammareri P, McCooey AJ, McCorry AMB, Fisher NC, Davis HL, Ridgway RA, Lohuis J, Leach JDG, Jackstadt R, Gilroy K, Mariella E, Nixon C, Clark W, Hedley A, Markert EK, Strathdee D, Bartholin L, Redmond KL, Kerr EM, Longley DB, Ginty F, Cho S, Coleman HG, Loughrey MB, Bardelli A, Maughan TS, Campbell AD, Lawler M, Leedham SJ, Barry ST, Inman GJ, van Rheenen J, Dunne PD, Sansom OJ

Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features.

Nat Commun 2022; 7551. doi: 10.1038/s41467-022-35134-3

Mariella E, Grasso G, Miotto M, Buzo K, Reilly NM, Andrei P, Vitiello PP, Crisafulli G, Arena S, Rospo G, Corti G, Lorenzato A, Cancelliere C, Barault L, Gionfriddo G, Linnebacher M, Russo M, Di Nicolantonio F, Bardelli A

Transcriptome-wide gene expression outlier analysis pinpoints therapeutic vulnerabilities in colorectal cancer.

Mol Oncol 2024; 1460-1485. doi: 10.1002/1878-0261.13622

López L, Morosi LG, La Terza F, Bourdely P, Rospo G, Amadio R, Piperno GM, Russo V, Volponi C, Vodret S, Joshi S, Giannese F, Lazarevic D, Germano G, Stoitzner P, Bardelli A, Dalod M, Pace L, Caronni N, Guermonprez P, Benvenuti F

Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors.

Nat Commun 2024; 2280. doi: 10.1038/s41467-024-46685-y

Roa P, Foglizzo V, Harada G, Repetto M, Kulick A, de Stanchina E, de Marchena M, Auwardt S, Sayed Ahmed S, Bremer NV, Yang SR, Feng Y, Zhou C, Kong N, Liang R, Xu H, Zhang B, Bardelli A, Toska E, Ventura A, Drilon A, Cocco E

Zurletrectinib is a next-generation TRK inhibitor with strong intracranial activity against NTRK fusion-positive tumours with on-target resistance to first-generation agents.

Br J Cancer 2024; 601-610. doi: 10.1038/s41416-024-02760-1

Russo M, Chen M, Mariella E, Peng H, Rehman SK, Sancho E, Sogari A, Toh TS, Balaban NQ, Batlle E, Bernards R, Garnett MJ, Hangauer M, Leucci E, Marine JC, O'Brien CA, Oren Y, Patton EE, Robert C, Rosenberg SM, Shen S, Bardelli A

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities.

Nat Rev Cancer 2024; 694-717. doi: 10.1038/s41568-024-00737-z

Pessei V, Macagno M, Mariella E, Congiusta N, Battaglieri V, Battuello P, Viviani M, Gionfriddo G, Lamba S, Lorenzato A, Oddo D, Idrees F, Cavaliere A, Bartolini A, Guarrera S, Linnebacher M, Monteonofrio L, Cardone L, Milella M, Bertotti A, Soddu S, Grassi E, Crisafulli G, Bardelli A, Barault L, Di Nicolantonio F

DNA demethylation triggers cell free DNA release in colorectal cancer cells.

Genome Med 2024; 118. doi: 10.1186/s13073-024-01386-5

Marasco M, Kumar D, Garcia Borrego S, Seale T, Maddalena G, Mezzadra R, Belanger K, Cole S, Perez B, Luan W, Mukherjee R, Aricescu I, Markov V, Zhu Y, Arena S, Bardelli A, de Stanchina E, Lowe SW, Burkhart RA, Zimmerman JW, Yaeger R, Kopetz SE, Rosen N, Misale S

Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations.

Cancer Discov 2025; 1392-1409. doi: 10.1158/2159-8290.CD-24-0614

Alaimo A, Carbone FG, Buzo K, Annesi N, Genovesi S, Lorenzato A, Widmann K, Libergoli M, Marmocchi E, Bertalot G, Brolese A, Papotti MG, Molinaro L, Caffo O, Barbareschi M, Bardelli A, Romanel A, Arena S, Lunardi A

TRPM8 levels determine tumor vulnerability to channel agonists.

Mol Oncol 2025; 2905-2920. doi: 10.1002/1878-0261.70049

Brunet L, Alexandre D, Lee J, Blanquer-Rosselló MDM, Bracquemond D, Guernet A, Chhouri H, Goupil M, Kherrouche Z, Arabo A, Mancini M, Cartier D, Yao S, Godefroy D, Dehedin J, Li JR, Duparc C, Jamme P, Vinchent A, Bérard C, Tulasne D, Arena S, Bardelli A, Cheng C, Cho BC, Wurtz O, Coulouarn C, Maraver A, Aaronson SA, Cortot AB, Anouar Y, Grumolato L

Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells.

Nat Commun 2025; 7853. doi: 10.1038/s41467-025-61788-w

Vitiello PP, Valsecchi AA, Duregon E, Di Celle PF, Cassoni P, Papotti M, Bardelli A, Di Maio M

KRAS G12C Inhibition in Solid Tumors: Biological Breakthroughs, Clinical Evidence, and Open Challenges.

Cancers (Basel) 2025; . doi: 10.3390/cancers17172803

Bardelli AM, Borgogni P, Farnetani MA, Fois A, Frezzotti R, Mattei R, Molinelli M, Sargentini I

Familial tyrosinaemia with eye and skin lesions. Presentation of two cases.

Ophthalmologica 1977; 5-9. doi: 10.1159/000308631

Naldini L, Weidner KM, Vigna E, Gaudino G, Bardelli A, Ponzetto C, Narsimhan RP, Hartmann G, Zarnegar R, Michalopoulos GK

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

EMBO J 1991; 2867-78. doi: 10.1002/j.1460-2075.1991.tb07836.x

Bardelli AM, Rottoli P, Panzardi G, Traversi C, Barberi L, Vagliasindi M

Unusual optic nerve lesion in sarcoidosis.

Sarcoidosis 1991; 72-4.

Dotti MT, Rossi A, Rizzuto N, Hayek G, Bardelli N, Bardelli AM, Federico A

Atypical phenotype of Refsum's disease: clinical, biochemical, neurophysiological and pathological study.

Eur Neurol 1985; 85-93. doi: 10.1159/000115767

Mastrangelo D, Di Pisa F, Hadjistilianou T, Bardelli AM, Silvestri S, Frezzotti R

Retinoblastoma. Analysis of 75 cases and proposal for a new model of oncogenesis and tumor growth kinetics.

Ophthalmic Paediatr Genet 1989; 161-71. doi: 10.3109/13816818909009872

Federico A, Manneschi L, Meloni M, Alessandrini C, Bardelli AM, Dotti MT, Sabatelli P

Histochemical, ultrastructural and biochemical study of muscle mitochondria in Leber's hereditary optic atrophy.

J Inherit Metab Dis 1988; 193-7. doi: 10.1007/BF01804233

Annunziata P, Pero G, Ibba L, Federico A, Bardelli AM, Sabatelli P, Guazzi GC

Adult dementia in three siblings: ceroid-lipofuscinosis.

Acta Neurol (Napoli) 1986; 528-34.

Bardelli AM, Hadjistilianou T, Barberi L

Aicardi's syndrome.

Ophthalmic Paediatr Genet 1985; 141-4. doi: 10.3109/13816818509006125

Fois A, Bardelli AM, Frezzotti R, Acquaviva A, Bernardini C, Hadjistilianou T

Combined treatment modalities of orbital rhabdomyosarcoma in children.

Eur J Pediatr 1986; 514-5. doi: 10.1007/BF00441754

Bardelli AM, Biagini L, Barberi L

Leber's optic neuritis.

Ophthalmic Paediatr Genet 1985; 133-40. doi: 10.3109/13816818509006124

Bardelli AM, Hadjistilianou T, Frezzotti R

Etiology of congenital glaucoma. Genetic and extragenetic factors.

Ophthalmic Paediatr Genet 1985; 265-70.

Bardelli AM, Lasorella G

Primary and secondary ocular tumors in children.

J Neurosurg Sci 1982; 11-6.

Giuffrè R, Bardelli AM, Taverniti L, Barberi L

Anterior optic pathways gliomas. The dilemma of treatment.

J Neurosurg Sci 1982; 61-72.

Motolese E, Esposti P, Bardelli AM, Frezzotti R

Echographic study of exophthalmos and neoformative endocular pathology in childhood.

J Neurosurg Sci 1982; 17-20.

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