Walerych D, Lisek K, Del Sal G

Multi-omics reveals global effects of mutant p53 gain-of-function.

Cell Cycle 2016; 3009-3010. doi: 10.1080/15384101.2016.1215703

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Walerych D, Lisek K, Sommaggio R, Piazza S, Ciani Y, Dalla E, Rajkowska K, Gaweda-Walerych K, Ingallina E, Tonelli C, Morelli MJ, Amato A, Eterno V, Zambelli A, Rosato A, Amati B, Wiśniewski JR, Del Sal G

Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer.

Nat Cell Biol 2016; 897-909. doi: 10.1038/ncb3380

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Garibaldi F, Falcone E, Trisciuoglio D, Colombo T, Lisek K, Walerych D, Del Sal G, Paci P, Bossi G, Piaggio G, Gurtner A

Mutant p53 inhibits miRNA biogenesis by interfering with the microprocessor complex.

Oncogene 2016; 3760-70. doi: 10.1038/onc.2016.51

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D'Artista L, Bisso A, Piontini A, Doni M, Verrecchia A, Kress TR, Morelli MJ, Del Sal G, Amati B, Campaner S

Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc.

Oncotarget 2016; 21786-98. doi: 10.18632/oncotarget.7846

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Di Agostino S, Sorrentino G, Ingallina E, Valenti F, Ferraiuolo M, Bicciato S, Piazza S, Strano S, Del Sal G, Blandino G

YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins.

EMBO Rep 2016; 188-201. doi: 10.15252/embr.201540488

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Agostoni E, Michelazzi S, Maurutto M, Carnemolla A, Ciani Y, Vatta P, Roncaglia P, Zucchelli S, Leanza G, Mantovani F, Gustincich S, Santoro C, Piazza S, Del Sal G, Persichetti F

Effects of Pin1 Loss in Hdh(Q111) Knock-in Mice.

Front Cell Neurosci 2016; 110. doi: 10.3389/fncel.2016.00110

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Taccioli C, Sorrentino G, Zannini A, Caroli J, Beneventano D, Anderlucci L, Lolli M, Bicciato S, Del Sal G

MDP, a database linking drug response data to genomic information, identifies dasatinib and statins as a combinatorial strategy to inhibit YAP/TAZ in cancer cells.

Oncotarget 2015; 38854-65. doi: 10.18632/oncotarget.5749

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Mantovani F, Zannini A, Rustighi A, Del Sal G

Interaction of p53 with prolyl isomerases: Healthy and unhealthy relationships.

Biochim Biophys Acta 2015; 2048-60. doi: 10.1016/j.bbagen.2015.01.013

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Farra R, Dapas B, Baiz D, Tonon F, Chiaretti S, Del Sal G, Rustighi A, Elvassore N, Pozzato G, Grassi M, Grassi G

Impairment of the Pin1/E2F1 axis in the anti-proliferative effect of bortezomib in hepatocellular carcinoma cells.

Biochimie 2015; 85-95. doi: 10.1016/j.biochi.2015.02.015

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Vermezovic J, Adamowicz M, Santarpia L, Rustighi A, Forcato M, Lucano C, Massimiliano L, Costanzo V, Bicciato S, Del Sal G, d'Adda di Fagagna F

Notch is a direct negative regulator of the DNA-damage response.

Nat Struct Mol Biol 2015; 417-24. doi: 10.1038/nsmb.3013

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Paneni F, Costantino S, Castello L, Battista R, Capretti G, Chiandotto S, D'Amario D, Scavone G, Villano A, Rustighi A, Crea F, Pitocco D, Lanza G, Volpe M, Del Sal G, Lüscher TF, Cosentino F

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes.

Eur Heart J 2015; 817-28. doi: 10.1093/eurheartj/ehu179

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Giorgi C, Bonora M, Sorrentino G, Missiroli S, Poletti F, Suski JM, Galindo Ramirez F, Rizzuto R, Di Virgilio F, Zito E, Pandolfi PP, Wieckowski MR, Mammano F, Del Sal G, Pinton P

p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner.

Proc Natl Acad Sci U S A 2015; 1779-84. doi: 10.1073/pnas.1410723112

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Sorrentino G, Comel A, Del Sal G

p53 orchestrates calcium signaling in vivo.

Cell Cycle 2015; 1343-4. doi: 10.1080/15384101.2015.1024583

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Walerych D, Lisek K, Del Sal G

Mutant p53: One, No One, and One Hundred Thousand.

Front Oncol 2015; 289. doi: 10.3389/fonc.2015.00289

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Di Minin G, Bellazzo A, Dal Ferro M, Chiaruttini G, Nuzzo S, Bicciato S, Piazza S, Rami D, Bulla R, Sommaggio R, Rosato A, Del Sal G, Collavin L

Mutant p53 reprograms TNF signaling in cancer cells through interaction with the tumor suppressor DAB2IP.

Mol Cell 2014; 617-29. doi: 10.1016/j.molcel.2014.10.013

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Sorrentino G, Comel A, Mantovani F, Del Sal G

Regulation of mitochondrial apoptosis by Pin1 in cancer and neurodegeneration.

Mitochondrion 2014; 88-96. doi: 10.1016/j.mito.2014.08.003

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Antonelli R, Pizzarelli R, Pedroni A, Fritschy JM, Del Sal G, Cherubini E, Zacchi P

Pin1-dependent signalling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interaction.

Nat Commun 2014; 5066. doi: 10.1038/ncomms6066

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Comel A, Sorrentino G, Capaci V, Del Sal G

The cytoplasmic side of p53's oncosuppressive activities.

FEBS Lett 2014; 2600-9. doi: 10.1016/j.febslet.2014.04.015

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Restelli M, Lopardo T, Lo Iacono N, Garaffo G, Conte D, Rustighi A, Napoli M, Del Sal G, Perez-Morga D, Costanzo A, Merlo GR, Guerrini L

DLX5, FGF8 and the Pin1 isomerase control ΔNp63α protein stability during limb development: a regulatory loop at the basis of the SHFM and EEC congenital malformations.

Hum Mol Genet 2014; 3830-42. doi: 10.1093/hmg/ddu096

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Sorrentino G, Ruggeri N, Specchia V, Cordenonsi M, Mano M, Dupont S, Manfrin A, Ingallina E, Sommaggio R, Piazza S, Rosato A, Piccolo S, Del Sal G

Metabolic control of YAP and TAZ by the mevalonate pathway.

Nat Cell Biol 2014; 357-66. doi: 10.1038/ncb2936

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Ciarapica R, Methot L, Tang Y, Lo R, Dali R, Buscarlet M, Locatelli F, del Sal G, Rota R, Stifani S

Prolyl isomerase Pin1 and protein kinase HIPK2 cooperate to promote cortical neurogenesis by suppressing Groucho/TLE:Hes1-mediated inhibition of neuronal differentiation.

Cell Death Differ 2014; 321-32. doi: 10.1038/cdd.2013.160

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Girardini JE, Marotta C, Del Sal G

Disarming mutant p53 oncogenic function.

Pharmacol Res 2014; 75-87. doi: 10.1016/j.phrs.2013.11.003

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Rustighi A, Zannini A, Tiberi L, Sommaggio R, Piazza S, Sorrentino G, Nuzzo S, Tuscano A, Eterno V, Benvenuti F, Santarpia L, Aifantis I, Rosato A, Bicciato S, Zambelli A, Del Sal G

Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast.

EMBO Mol Med 2014; 99-119. doi: 10.1002/emmm.201302909

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Quy VC, Carnevale V, Manganaro L, Lusic M, Rossetti G, Leone V, Fenollar-Ferrer C, Raugei S, Del Sal G, Giacca M, Carloni P

HIV-1 integrase binding to its cellular partners: a perspective from computational biology.

Curr Pharm Des 2014; 3412-21. doi: 10.2174/13816128113199990631

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Girardini JE, Walerych D, Del Sal G

Cooperation of p53 mutations with other oncogenic alterations in cancer.

Subcell Biochem 2014; 41-70. doi: 10.1007/978-94-017-9211-0_3

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Castiglioni V, De Maglie M, Queliti R, Rustighi A, Del Sal G, Radaelli E

Immunohistochemical Characterization of a Renal Nephroblastoma in a Trp53-mutant and Prolyl Isomerase 1-deficient Mouse.

J Toxicol Pathol 2013; 423-7. doi: 10.1293/tox.2013-0021

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Bitomsky N, Conrad E, Moritz C, Polonio-Vallon T, Sombroek D, Schultheiss K, Glas C, Greiner V, Herbel C, Mantovani F, del Sal G, Peri F, Hofmann TG

Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death.

Proc Natl Acad Sci U S A 2013; E4203-12. doi: 10.1073/pnas.1310001110

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Pegoraro S, Ros G, Piazza S, Sommaggio R, Ciani Y, Rosato A, Sgarra R, Del Sal G, Manfioletti G

HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness.

Oncotarget 2013; 1293-308. doi: 10.18632/oncotarget.1136

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Bisso A, Faleschini M, Zampa F, Capaci V, De Santa J, Santarpia L, Piazza S, Cappelletti V, Daidone M, Agami R, Del Sal G

Oncogenic miR-181a/b affect the DNA damage response in aggressive breast cancer.

Cell Cycle 2013; 1679-87. doi: 10.4161/cc.24757

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Steger M, Murina O, Hühn D, Ferretti LP, Walser R, Hänggi K, Lafranchi L, Neugebauer C, Paliwal S, Janscak P, Gerrits B, Del Sal G, Zerbe O, Sartori AA

Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection.

Mol Cell 2013; 333-43. doi: 10.1016/j.molcel.2013.03.023

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Sonego M, Schiappacassi M, Lovisa S, Dall'Acqua A, Bagnoli M, Lovat F, Libra M, D'Andrea S, Canzonieri V, Militello L, Napoli M, Giorda G, Pivetta B, Mezzanzanica D, Barbareschi M, Valeri B, Canevari S, Colombatti A, Belletti B, Del Sal G, Baldassarre G

Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer.

EMBO Mol Med 2013; 707-22. doi: 10.1002/emmm.201201504

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Sorrentino G, Mioni M, Giorgi C, Ruggeri N, Pinton P, Moll U, Mantovani F, Del Sal G

The prolyl-isomerase Pin1 activates the mitochondrial death program of p53.

Cell Death Differ 2013; 198-208. doi: 10.1038/cdd.2012.112

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Walerych D, Napoli M, Collavin L, Del Sal G

The rebel angel: mutant p53 as the driving oncogene in breast cancer.

Carcinogenesis 2012; 2007-17. doi: 10.1093/carcin/bgs232

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Vilotti S, Biagioli M, Foti R, Dal Ferro M, Lavina ZS, Collavin L, Del Sal G, Zucchelli S, Gustincich S

The PML nuclear bodies-associated protein TTRAP regulates ribosome biogenesis in nucleolar cavities upon proteasome inhibition.

Cell Death Differ 2012; 488-500. doi: 10.1038/cdd.2011.118

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Napoli M, Girardini JE, Del Sal G

Polo-like kinase 2: a new exploitable target to undermine mutant p53-dependent chemoresistance.

Cell Cycle 2012; 438. doi: 10.4161/cc.11.3.19225

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Grison A, Mantovani F, Comel A, Agostoni E, Gustincich S, Persichetti F, Del Sal G

Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.

Proc Natl Acad Sci U S A 2011; 17979-84. doi: 10.1073/pnas.1106198108

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Napoli M, Girardini JE, Piazza S, Del Sal G

Wiring the oncogenic circuitry: Pin1 unleashes mutant p53.

Oncotarget 2011; 654-6. doi: 10.18632/oncotarget.329

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Marcucci R, Brindle J, Paro S, Casadio A, Hempel S, Morrice N, Bisso A, Keegan LP, Del Sal G, O'Connell MA

Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects.

EMBO J 2011; 4211-22. doi: 10.1038/emboj.2011.303

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Girardini JE, Napoli M, Piazza S, Rustighi A, Marotta C, Radaelli E, Capaci V, Jordan L, Quinlan P, Thompson A, Mano M, Rosato A, Crook T, Scanziani E, Means AR, Lozano G, Schneider C, Del Sal G

A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.

Cancer Cell 2011; 79-91. doi: 10.1016/j.ccr.2011.06.004

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Bisso A, Collavin L, Del Sal G

p73 as a pharmaceutical target for cancer therapy.

Curr Pharm Des 2011; 578-90. doi: 10.2174/138161211795222667

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Magli A, Angelelli C, Ganassi M, Baruffaldi F, Matafora V, Battini R, Bachi A, Messina G, Rustighi A, Del Sal G, Ferrari S, Molinari S

Proline isomerase Pin1 represses terminal differentiation and myocyte enhancer factor 2C function in skeletal muscle cells.

J Biol Chem 2010; 34518-27. doi: 10.1074/jbc.M110.104133

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Mantovani F, Drost J, Voorhoeve PM, Del Sal G, Agami R

Gene regulation and tumor suppression by the bromodomain-containing protein BRD7.

Cell Cycle 2010; 2777-81.

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Foti R, Zucchelli S, Biagioli M, Roncaglia P, Vilotti S, Calligaris R, Krmac H, Girardini JE, Del Sal G, Gustincich S

Parkinson disease-associated DJ-1 is required for the expression of the glial cell line-derived neurotrophic factor receptor RET in human neuroblastoma cells.

J Biol Chem 2010; 18565-74. doi: 10.1074/jbc.M109.088294

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Collavin L, Lunardi A, Del Sal G

p53-family proteins and their regulators: hubs and spokes in tumor suppression.

Cell Death Differ 2010; 901-11. doi: 10.1038/cdd.2010.35

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Girardini JE, Del Sal G

Improving pharmacological rescue of p53 function: RITA targets mutant p53.

Cell Cycle 2010; 2062.

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Lunardi A, Di Minin G, Provero P, Dal Ferro M, Carotti M, Del Sal G, Collavin L

A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network.

Proc Natl Acad Sci U S A 2010; 6322-7. doi: 10.1073/pnas.1002447107

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Drost J, Mantovani F, Tocco F, Elkon R, Comel A, Holstege H, Kerkhoven R, Jonkers J, Voorhoeve PM, Agami R, Del Sal G

BRD7 is a candidate tumour suppressor gene required for p53 function.

Nat Cell Biol 2010; 380-9. doi: 10.1038/ncb2038

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Manganaro L, Lusic M, Gutierrez MI, Cereseto A, Del Sal G, Giacca M

Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD4+ T lymphocytes.

Nat Med 2010; 329-33. doi: 10.1038/nm.2102

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Lunardi A, Chiacchiera F, D'Este E, Carotti M, Dal Ferro M, Di Minin G, Del Sal G, Collavin L

The evolutionary conserved gene C16orf35 encodes a nucleo-cytoplasmic protein that interacts with p73.

Biochem Biophys Res Commun 2009; 428-33. doi: 10.1016/j.bbrc.2009.08.027

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Carnemolla A, Fossale E, Agostoni E, Michelazzi S, Calligaris R, De Maso L, Del Sal G, MacDonald ME, Persichetti F

Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease.

J Biol Chem 2009; 18167-73. doi: 10.1074/jbc.M109.018325

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