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A planar-polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia.

bioRxiv 2023; . doi: 10.1101/2023.01.23.524898

Martin S, Scorzoni S, Cordone S, Mazzagatti A, Beznoussenko GV, Gunn AL, Di Bona M, Eliezer Y, Leor G, Ben-Yishay T, Loffreda A, Cancila V, Rainone MC, Ippolito MR, Martis V, Bedin F, Garrè M, Vaites LP, Vasapolli P, Polo S, Parazzoli D, Tripodo C, Mironov AA, Cuomo A, Ben-David U, Bakhoum SF, Hatch EM, Ly P, Santaguida S

A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements.

Science 2024; eadj7446. doi: 10.1126/science.adj7446

Innocenti M, Gerboth S, Rottner K, Lai FP, Hertzog M, Stradal TE, Frittoli E, Didry D, Polo S, Disanza A, Benesch S, Di Fiore PP, Carlier MF, Scita G

Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes.

Nat Cell Biol 2005; 969-76. doi: 10.1038/ncb1304

Polo S, Pece S, Di Fiore PP

Endocytosis and cancer.

Curr Opin Cell Biol 2004; 156-61. doi: 10.1016/j.ceb.2004.02.003

Sigismund S, Polo S, Di Fiore PP

Signaling through monoubiquitination.

Curr Top Microbiol Immunol 2004; 149-85. doi: 10.1007/978-3-540-69494-6_6

Sigismund S, Woelk T, Puri C, Maspero E, Tacchetti C, Transidico P, Di Fiore PP, Polo S

Clathrin-independent endocytosis of ubiquitinated cargos.

Proc Natl Acad Sci U S A 2005; 2760-5. doi: 10.1073/pnas.0409817102

Benesch S, Polo S, Lai FP, Anderson KI, Stradal TE, Wehland J, Rottner K

N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits.

J Cell Sci 2005; 3103-15. doi: 10.1242/jcs.02444

Mao Y, Senic-Matuglia F, Di Fiore PP, Polo S, Hodsdon ME, De Camilli P

Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain.

Proc Natl Acad Sci U S A 2005; 12700-5. doi: 10.1073/pnas.0506344102

Penengo L, Mapelli M, Murachelli AG, Confalonieri S, Magri L, Musacchio A, Di Fiore PP, Polo S, Schneider TR

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin.

Cell 2006; 1183-95. doi: 10.1016/j.cell.2006.02.020

Woelk T, Oldrini B, Maspero E, Confalonieri S, Cavallaro E, Di Fiore PP, Polo S

Molecular mechanisms of coupled monoubiquitination.

Nat Cell Biol 2006; 1246-54. doi: 10.1038/ncb1484

Lai FP, Szczodrak M, Oelkers JM, Ladwein M, Acconcia F, Benesch S, Auinger S, Faix J, Small JV, Polo S, Stradal TE, Rottner K

Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases.

Mol Biol Cell 2009; 3209-23. doi: 10.1091/mbc.e08-12-1180

Frosi Y, Anastasi S, Ballarò C, Varsano G, Castellani L, Maspero E, Polo S, Alemà S, Segatto O

A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation.

J Cell Biol 2010; 557-71. doi: 10.1083/jcb.201002032

Argenzio E, Bange T, Oldrini B, Bianchi F, Peesari R, Mari S, Di Fiore PP, Mann M, Polo S

Proteomic snapshot of the EGF-induced ubiquitin network.

Mol Syst Biol 2011; 462. doi: 10.1038/msb.2010.118

Maspero E, Valentini E, Mari S, Cecatiello V, Soffientini P, Pasqualato S, Polo S

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.

Nat Struct Mol Biol 2013; 696-701. doi: 10.1038/nsmb.2566

Boissan M, Montagnac G, Shen Q, Griparic L, Guitton J, Romao M, Sauvonnet N, Lagache T, Lascu I, Raposo G, Desbourdes C, Schlattner U, Lacombe ML, Polo S, van der Bliek AM, Roux A, Chavrier P

Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling.

Science 2014; 1510-5. doi: 10.1126/science.1253768

Persaud A, Alberts P, Mari S, Tong J, Murchie R, Maspero E, Safi F, Moran MF, Polo S, Rotin D

Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity.

Sci Signal 2014; ra95. doi: 10.1126/scisignal.2005290

Savio MG, Wollscheid N, Cavallaro E, Algisi V, Di Fiore PP, Sigismund S, Maspero E, Polo S

USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15.

Curr Biol 2016; 173-183. doi: 10.1016/j.cub.2015.11.050

Wollscheid HP, Biancospino M, He F, Magistrati E, Molteni E, Lupia M, Soffientini P, Rottner K, Cavallaro U, Pozzoli U, Mapelli M, Walters KJ, Polo S

Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.

Nat Struct Mol Biol 2016; 300-308. doi: 10.1038/nsmb.3187

He F, Wollscheid HP, Nowicka U, Biancospino M, Valentini E, Ehlinger A, Acconcia F, Magistrati E, Polo S, Walters KJ

Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains.

Cell Rep 2016; 2683-94. doi: 10.1016/j.celrep.2016.01.079

Myant KB, Cammareri P, Hodder MC, Wills J, Von Kriegsheim A, Győrffy B, Rashid M, Polo S, Maspero E, Vaughan L, Gurung B, Barry E, Malliri A, Camargo F, Adams DJ, Iavarone A, Lasorella A, Sansom OJ

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.

EMBO Mol Med 2017; 181-197. doi: 10.15252/emmm.201606684

Caldieri G, Barbieri E, Nappo G, Raimondi A, Bonora M, Conte A, Verhoef LGGC, Confalonieri S, Malabarba MG, Bianchi F, Cuomo A, Bonaldi T, Martini E, Mazza D, Pinton P, Tacchetti C, Polo S, Di Fiore PP, Sigismund S

Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis.

Science 2017; 617-624. doi: 10.1126/science.aah6152

Kam CY, Dubash AD, Magistrati E, Polo S, Satchell KJF, Sheikh F, Lampe PD, Green KJ

Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43.

J Cell Biol 2018; 3219-3235. doi: 10.1083/jcb.201710161

Castagnoli L, Mandaliti W, Nepravishta R, Valentini E, Mattioni A, Procopio R, Iannuccelli M, Polo S, Paci M, Cesareni G, Santonico E

Selectivity of the CUBAN domain in the recognition of ubiquitin and NEDD8.

FEBS J 2019; 653-677. doi: 10.1111/febs.14752

Colombo A, Fontani M, Dragonetti C, Roberto D, Williams JAG, Scotto di Perrotolo R, Casagrande F, Barozzi S, Polo S

A Highly Luminescent Tetrahydrocurcumin IrIII Complex with Remarkable Photoactivated Anticancer Activity.

Chemistry 2019; 7948-7952. doi: 10.1002/chem.201901527

Pascolutti R, Algisi V, Conte A, Raimondi A, Pasham M, Upadhyayula S, Gaudin R, Maritzen T, Barbieri E, Caldieri G, Tordonato C, Confalonieri S, Freddi S, Malabarba MG, Maspero E, Polo S, Tacchetti C, Haucke V, Kirchhausen T, Di Fiore PP, Sigismund S

Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling.

Cell Rep 2019; 3049-3061.e6. doi: 10.1016/j.celrep.2019.05.017

Wagner W, Lippmann K, Heisler FF, Gromova KV, Lombino FL, Roesler MK, Pechmann Y, Hornig S, Schweizer M, Polo S, Schwarz JR, Eilers J, Kneussel M

Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.

Cell Rep 2019; 11-20.e9. doi: 10.1016/j.celrep.2019.06.005

Nepravishta R, Ferrentino F, Mandaliti W, Mattioni A, Weber J, Polo S, Castagnoli L, Cesareni G, Paci M, Santonico E

CoCUN, a Novel Ubiquitin Binding Domain Identified in N4BP1.

Biomolecules 2019; . doi: 10.3390/biom9070284

Biancospino M, Buel GR, Niño CA, Maspero E, Scotto di Perrotolo R, Raimondi A, Redlingshöfer L, Weber J, Brodsky FM, Walters KJ, Polo S

Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension.

Nat Commun 2019; 4974. doi: 10.1038/s41467-019-12855-6

Dhanda AS, Yu C, Lulic KT, Vogl AW, Rausch V, Yang D, Nichols BJ, Kim SH, Polo S, Hansen CG, Guttman JA

Listeria monocytogenes Exploits Host Caveolin for Cell-to-Cell Spreading.

mBio 2020; . doi: 10.1128/mBio.02857-19

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